Abstract
We tested how certain antagonists of 5-HT-3 receptors affect ethanol consumption and withdrawal seizures in ethanol-dependent Wistar male rats. Low doses of tropisetron (0.001-0.01 mg/kg ip) and ondansetron (0.00025 mg/kg ip) reduced ethanol consumption and preference. Increased ethanol intake was observed, however, after administration of higher doses of ondansetron (0.125 g/kg ip) and granisetron (0.125-0.25 mg/kg ip). Audiogenic seizures in rats withdrawn from ethanol were attenuated by low doses of tropisetron and ondansetron.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acoustic Stimulation
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Alcoholism / drug therapy*
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Animals
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Disease Models, Animal
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Ethanol / toxicity*
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Granisetron / administration & dosage
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Granisetron / pharmacology
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Granisetron / therapeutic use
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Indoles / administration & dosage
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Indoles / pharmacology
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Indoles / therapeutic use
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Male
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Ondansetron / administration & dosage
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Ondansetron / pharmacology
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Ondansetron / therapeutic use
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Rats
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Rats, Wistar
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Receptors, Serotonin / drug effects
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Seizures / drug therapy*
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Seizures / etiology
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Serotonin Antagonists / administration & dosage
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Serotonin Antagonists / pharmacology
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Serotonin Antagonists / therapeutic use*
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Substance Withdrawal Syndrome / drug therapy*
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Tropisetron
Substances
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Indoles
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Receptors, Serotonin
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Serotonin Antagonists
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Ethanol
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Ondansetron
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Tropisetron
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Granisetron