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Association of Polymorphism in the Receptor for Advanced Glycation End Products (RAGE) Gene with Circulating RAGE Levels.

Gaens KH, Ferreira I, van der Kallen CJ, van Greevenbroek MM, Blaak EE, Feskens EJ, Dekker JM, Nijpels G, Heine RJ, 't Hart LM, de Groot PG, Stehouwer CD, Schalkwijk CG.

J Clin Endocrinol Metab. 2009 Nov 4. [Epub ahead of print]PMID: 19890027 [PubMed - as supplied by publisher]Related articles

Genetic association analysis of LARS2 with type 2 diabetes.

Reiling E, Jafar-Mohammadi B, van 't Riet E, Weedon MN, van Vliet-Ostaptchouk JV, Hansen T, Saxena R, van Haeften TW, Arp PA, Das S, Nijpels G, Groenewoud MJ, van Hove EC, Uitterlinden AG, Smit JW, Morris AD, Doney AS, Palmer CN, Guiducci C, Hattersley AT, Frayling TM, Pedersen O, Slagboom PE, Altshuler DM, Groop L, Romijn JA, Maassen JA, Hofker MH, Dekker JM, McCarthy MI, 't Hart LM.

Diabetologia. 2009 Oct 22. [Epub ahead of print]PMID: 19847392 [PubMed - as supplied by publisher]Related articles

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A and MTNR1B affect different aspects of pancreatic beta cell function.

Simonis-Bik AM, Nijpels G, van Haeften TW, Houwing-Duistermaat JJ, Boomsma DI, Reiling E, van Hove EC, Diamant M, Kramer MH, Heine RJ, Maassen JA, Slagboom PE, Willemsen G, Dekker JM, Eekhoff EM, de Geus EJ, 't Hart LM.

Diabetes. 2009 Oct 15. [Epub ahead of print]PMID: 19833888 [PubMed - as supplied by publisher]Related articles

A Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First Phase Glucose Stimulated Insulin Secretion During Hyperglycemic Clamps.

't Hart LM, Simonis-Bik AM, Nijpels G, van Haeften TW, Schäfer SA, Houwing-Duistermaat JJ, Boomsma DI, Groenewoud MJ, Reiling E, van Hove EC, Diamant M, Kramer MH, Heine RJ, Maassen JA, Kirchhoff K, Machicao F, Häring HU, Slagboom PE, Willemsen G, Eekhoff EM, de Geus EJ, Dekker JM, Fritsche A.

Diabetes. 2009 Oct 6. [Epub ahead of print]PMID: 19808892 [PubMed - as supplied by publisher]Related articles

Genetic influences on the insulin response of the beta cell to different secretagogues.

Simonis-Bik AM, Eekhoff EM, de Moor MH, Kramer MH, Boomsma DI, Heine RJ, Dekker JM, Maassen JA, 't Hart LM, Diamant M, de Geus EJ.

Diabetologia. 2009 Oct 3. [Epub ahead of print]PMID: 19802603 [PubMed - as supplied by publisher]Related articles

Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.

Reiling E, van 't Riet E, Groenewoud MJ, Welschen LM, van Hove EC, Nijpels G, Maassen JA, Dekker JM, 't Hart LM.

Diabetologia. 2009 Sep;52(9):1866-70. Epub 2009 Jun 17.PMID: 19533084 [PubMed - in process]Related articlesFree article

Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.

Reiling E, van Vliet-Ostaptchouk JV, van 't Riet E, van Haeften TW, Arp PA, Hansen T, Kremer D, Groenewoud MJ, van Hove EC, Romijn JA, Smit JW, Nijpels G, Heine RJ, Uitterlinden AG, Pedersen O, Slagboom PE, Maassen JA, Hofker MH, 't Hart LM, Dekker JM.

Eur J Hum Genet. 2009 Aug;17(8):1056-62. Epub 2009 Feb 11.PMID: 19209188 [PubMed - indexed for MEDLINE]Related articles

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps.

Groenewoud MJ, Dekker JM, Fritsche A, Reiling E, Nijpels G, Heine RJ, Maassen JA, Machicao F, Schäfer SA, Häring HU, 't Hart LM, van Haeften TW.

Diabetologia. 2008 Sep;51(9):1659-63. Epub 2008 Jul 11.PMID: 18618095 [PubMed - indexed for MEDLINE]Related articles

Lessons that can be learned from patients with diabetogenic mutations in mitochondrial DNA: implications for common type 2 diabetes.

Maassen JA, 't Hart LM, Ouwens DM.

Curr Opin Clin Nutr Metab Care. 2007 Nov;10(6):693-7. Review.PMID: 18089949 [PubMed - indexed for MEDLINE]Related articles

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

Schäfer SA, Tschritter O, Machicao F, Thamer C, Stefan N, Gallwitz B, Holst JJ, Dekker JM, 't Hart LM, Nijpels G, van Haeften TW, Häring HU, Fritsche A.

Diabetologia. 2007 Dec;50(12):2443-50. Epub 2007 Jul 28. Erratum in: Diabetologia. 2008 Jan;51(1):208. t' Hart, L M [corrected to 't Hart, L M]. Diabetologia. 2009 Mar;52(3):557. Dosage error in article text. PMID: 17661009 [PubMed - indexed for MEDLINE]Related articlesFree article

The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study.

van Hove EC, Hansen T, Dekker JM, Reiling E, Nijpels G, Jørgensen T, Borch-Johnsen K, Hamid YH, Heine RJ, Pedersen O, Maassen JA, 't Hart LM.

Diabetes. 2006 Nov;55(11):3193-6.PMID: 17065362 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial diabetes and its lessons for common Type 2 diabetes.

Maassen JA, 't Hart LM, Janssen GM, Reiling E, Romijn JA, Lemkes HH.

Biochem Soc Trans. 2006 Nov;34(Pt 5):819-23.PMID: 17052206 [PubMed - indexed for MEDLINE]Related articles

Inflammation and apoptosis genes and the risk of restenosis after percutaneous coronary intervention.

Monraats PS, de Vries F, de Jong LW, Pons D, Sewgobind VD, Zwinderman AH, de Maat MP, 't Hart LM, Doevendans PA, de Winter RJ, Tio RA, Waltenberger J, Frants RR, van der Laarse A, van der Wall EE, Wouter Jukema J.

Pharmacogenet Genomics. 2006 Oct;16(10):747-54.PMID: 17001294 [PubMed - in process]Related articles

Progressive sensorineural hearing impairment in maternally inherited diabetes mellitus and deafness (MIDD).

Hendrickx JJ, Mudde AH, 't Hart LM, Huygen PL, Cremers CW.

Otol Neurotol. 2006 Sep;27(6):802-8.PMID: 16788417 [PubMed - indexed for MEDLINE]Related articles

Novel mitochondrial DNA length variants and genetic instability in a family with diabetes and deafness.

Janssen GM, Neu A, 't Hart LM, van de Sande CM, Antonie Maassen J.

Exp Clin Endocrinol Diabetes. 2006 Apr;114(4):168-74.PMID: 16705548 [PubMed - indexed for MEDLINE]Related articles

New insights in the molecular pathogenesis of the maternally inherited diabetes and deafness syndrome.

Maassen JA, Jahangir Tafrechi RS, Janssen GM, Raap AK, Lemkes HH, 't Hart LM.

Endocrinol Metab Clin North Am. 2006 Jun;35(2):385-96, x-xi. Review.PMID: 16632100 [PubMed - indexed for MEDLINE]Related articles

Tumor necrosis factor-alpha plays an important role in restenosis development.

Monraats PS, Pires NM, Schepers A, Agema WR, Boesten LS, de Vries MR, Zwinderman AH, de Maat MP, Doevendans PA, de Winter RJ, Tio RA, Waltenberger J, 't Hart LM, Frants RR, Quax PH, van Vlijmen BJ, Havekes LM, van der Laarse A, van der Wall EE, Jukema JW.

FASEB J. 2005 Dec;19(14):1998-2004.PMID: 16319143 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular mechanisms of mitochondrial diabetes (MIDD).

Maassen JA, Janssen GM, 't Hart LM.

Ann Med. 2005;37(3):213-21. Review.PMID: 16019720 [PubMed - indexed for MEDLINE]Related articles

Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene.

't Hart LM, Hansen T, Rietveld I, Dekker JM, Nijpels G, Janssen GM, Arp PA, Uitterlinden AG, Jørgensen T, Borch-Johnsen K, Pols HA, Pedersen O, van Duijn CM, Heine RJ, Maassen JA.

Diabetes. 2005 Jun;54(6):1892-5.PMID: 15919814 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial diabetes: molecular mechanisms and clinical presentation.

Maassen JA, 'T Hart LM, Van Essen E, Heine RJ, Nijpels G, Jahangir Tafrechi RS, Raap AK, Janssen GM, Lemkes HH.

Diabetes. 2004 Feb;53 Suppl 1:S103-9. Review.PMID: 14749274 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic factors and insulin secretion: gene variants in the IGF genes.

't Hart LM, Fritsche A, Rietveld I, Dekker JM, Nijpels G, Machicao F, Stumvoll M, van Duijn CM, Häring HU, Heine RJ, Maassen JA, van Haeften TW.

Diabetes. 2004 Feb;53 Suppl 1:S26-30.PMID: 14749262 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus.

't Hart LM, Maassen JA, Dekker JM, Heine RJ, Maassen JA.

Diabetologia. 2003 Jul;46(7):1023-4. Epub 2003 Jun 21. No abstract available. PMID: 12827243 [PubMed - indexed for MEDLINE]Related articles

Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell.

't Hart LM, van Haeften TW, Dekker JM, Bot M, Heine RJ, Maassen JA.

Diabetes. 2002 Oct;51(10):3135-8.PMID: 12351459 [PubMed - indexed for MEDLINE]Related articlesFree article

A case of a de novo A3243G mutation in mitochondrial DNA in a patient with diabetes and deafness.

Maassen JA, Biberoglu S, 't Hart LM, Bakker E, de Knijff P.

Arch Physiol Biochem. 2002 Jul;110(3):186-8.PMID: 12221518 [PubMed - indexed for MEDLINE]Related articles

Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.

't Hart LM, Nijpels G, Dekker JM, Maassen JA, Heine RJ, van Haeften TW.

Diabetes. 2002 Mar;51(3):884-7.PMID: 11872698 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA-DQ polymorphism and degree of heteroplasmy of the A3243G mitochondrial DNA mutation in maternally inherited diabetes and deafness.

van Essen EH, Roep BO, 't Hart LM, Jansen JJ, Van den Ouweland JM, Lemkes HH, Maassen JA.

Diabet Med. 2000 Dec;17(12):841-7.PMID: 11168326 [PubMed - indexed for MEDLINE]Related articles

Maternally inherited diabetes and deafness (MIDD): unusual occult exocrine pancreatic manifestation in an affected German family.

Schleiffer T, 't Hart LM, Schürfeld C, Kraatz K, Riemann JF.

Exp Clin Endocrinol Diabetes. 2000;108(2):81-5.PMID: 10826513 [PubMed - indexed for MEDLINE]Related articles

Evaluation of the importance of maternal history of diabetes and of mitochondrial variation in the development of NIDDM.

McCarthy M, Cassell P, Tran T, Mathias L, 't Hart LM, Maassen JA, Snehalatha C, Ramachandran A, Viswanathan M, Hitman GA.

Diabet Med. 1996 May;13(5):420-8.PMID: 8737023 [PubMed - indexed for MEDLINE]Related articles

Heteroplasmy levels of a mitochondrial gene mutation associated with diabetes mellitus decrease in leucocyte DNA upon aging.

't Hart LM, Jansen JJ, Lemkes HH, de Knijff P, Maassen JA.

Hum Mutat. 1996;7(3):193-7.PMID: 8829651 [PubMed - indexed for MEDLINE]Related articles

The molecular basis and clinical characteristics of Maternally Inherited Diabetes and Deafness (MIDD), a recently recognized diabetic subtype.

Maassen JA, Jansen JJ, Kadowaki T, van den Ouweland JM, 't Hart LM, Lemkes HH.

Exp Clin Endocrinol Diabetes. 1996;104(3):205-11. Review.PMID: 8817237 [PubMed - indexed for MEDLINE]Related articles