PubMed

Long-term exendin-4 treatment delays natural deterioration of glycaemic control in diabetic Goto-Kakizaki rats.

Simonsen L, Pilgaard S, Orskov C, Hartmann B, Holst JJ, Deacon CF.

Diabetes Obes Metab. 2009 Sep;11(9):884-90. Epub 2009 Jun 5.PMID: 19508463 [PubMed - in process]Related articles

G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction.

Holst B, Egerod KL, Jin C, Petersen PS, Østergaard MV, Hald J, Sprinkel AM, Størling J, Mandrup-Poulsen T, Holst JJ, Thams P, Orskov C, Wierup N, Sundler F, Madsen OD, Schwartz TW.

Endocrinology. 2009 Jun;150(6):2577-85. Epub 2009 Feb 12.PMID: 19213833 [PubMed - indexed for MEDLINE]Related articles

Targets and tactics: the relative importance of HbA, fasting and postprandial plasma glucose levels to glycaemic control in type 2 diabetes.

Woo V, Shestakova MV, Ørskov C, Ceriello A.

Int J Clin Pract. 2008 Dec;62(12):1935-42. Review.PMID: 19166440 [PubMed - indexed for MEDLINE]Related articles

Good glycaemic control: an international perspective on bridging the gap between theory and practice in type 2 diabetes.

Kilpatrick ES, Das AK, Orskov C, Berntorp K.

Curr Med Res Opin. 2008 Sep;24(9):2651-61. Epub 2008 Aug 7.PMID: 18691443 [PubMed - indexed for MEDLINE]Related articles

MHC class II-associated invariant chain linkage of antigen dramatically improves cell-mediated immunity induced by adenovirus vaccines.

Holst PJ, Sorensen MR, Mandrup Jensen CM, Orskov C, Thomsen AR, Christensen JP.

J Immunol. 2008 Mar 1;180(5):3339-46.PMID: 18292559 [PubMed - indexed for MEDLINE]Related articlesFree article

Porcine glucagon-like peptide-2: structure, signaling, metabolism and effects.

Pedersen NB, Hjollund KR, Johnsen AH, Orskov C, Rosenkilde MM, Hartmann B, Holst JJ.

Regul Pept. 2008 Feb 7;146(1-3):310-20. Epub 2007 Nov 28.PMID: 18164496 [PubMed - indexed for MEDLINE]Related articles

The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas.

de Heer J, Pedersen J, Orskov C, Holst JJ.

Diabetologia. 2007 Oct;50(10):2135-42. Epub 2007 Aug 4.PMID: 17676310 [PubMed - indexed for MEDLINE]Related articles

CCR5 and CXCR3 are dispensable for liver infiltration, but CCR5 protects against virus-induced T-cell-mediated hepatic steatosis.

Holst PJ, Orskov C, Qvortrup K, Christensen JP, Thomsen AR.

J Virol. 2007 Sep;81(18):10101-12. Epub 2007 Jul 11.PMID: 17626099 [PubMed - indexed for MEDLINE]Related articlesFree article

Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes.

Nielsen LB, Ploug KB, Swift P, Ørskov C, Jansen-Olesen I, Chiarelli F, Holst JJ, Hougaard P, Pörksen S, Holl R, de Beaufort C, Gammeltoft S, Rorsman P, Mortensen HB, Hansen L; Hvidøre Study Group.

Eur J Endocrinol. 2007 Jun;156(6):663-71.PMID: 17535866 [PubMed - indexed for MEDLINE]Related articlesFree article

Meal-stimulated glucagon release is associated with postprandial blood glucose level and does not interfere with glycemic control in children and adolescents with new-onset type 1 diabetes.

Pörksen S, Nielsen LB, Kaas A, Kocova M, Chiarelli F, Orskov C, Holst JJ, Ploug KB, Hougaard P, Hansen L, Mortensen HB; Hvidøre Study Group on Childhood Diabetes.

J Clin Endocrinol Metab. 2007 Aug;92(8):2910-6. Epub 2007 May 22.PMID: 17519307 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats.

Simonsen L, Pilgaard S, Orskov C, Rosenkilde MM, Hartmann B, Holst JJ, Deacon CF.

Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G288-95. Epub 2007 Apr 12.PMID: 17431213 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibitory effect of GLP-1 on gastric motility persists after vagal deafferentation in pigs.

Nagell CF, Wettergren A, Ørskov C, Holst JJ.

Scand J Gastroenterol. 2006 Jun;41(6):667-72.PMID: 16716964 [PubMed - indexed for MEDLINE]Related articles

Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor.

Ugleholdt R, Poulsen ML, Holst PJ, Irminger JC, Orskov C, Pedersen J, Rosenkilde MM, Zhu X, Steiner DF, Holst JJ.

J Biol Chem. 2006 Apr 21;281(16):11050-7. Epub 2006 Feb 13.PMID: 16476726 [PubMed - indexed for MEDLINE]Related articlesFree article

MEK kinase 1 activity is required for definitive erythropoiesis in the mouse fetal liver.

Bonnesen B, Orskov C, Rasmussen S, Holst PJ, Christensen JP, Eriksen KW, Qvortrup K, Odum N, Labuda T.

Blood. 2005 Nov 15;106(10):3396-404. Epub 2005 Aug 4.PMID: 16081685 [PubMed - indexed for MEDLINE]Related articlesFree article

The incretin approach for diabetes treatment: modulation of islet hormone release by GLP-1 agonism.

Holst JJ, Orskov C.

Diabetes. 2004 Dec;53 Suppl 3:S197-204. Review.PMID: 15561911 [PubMed - indexed for MEDLINE]Related articlesFree article

GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors.

Ørskov C, Hartmann B, Poulsen SS, Thulesen J, Hare KJ, Holst JJ.

Regul Pept. 2005 Jan 15;124(1-3):105-12.PMID: 15544847 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice.

Thulesen J, Hartmann B, Hare KJ, Kissow H, Ørskov C, Holst JJ, Poulsen SS.

Gut. 2004 Aug;53(8):1145-50.PMID: 15247183 [PubMed - indexed for MEDLINE]Related articlesFree article

Typical Danish Caucasian type 2 diabetic patients do not commonly carry genetic variants in GIP and GLP-1 encoding regions of the proGIP and proglucagon genes.

Ørskov C, Hjorth SA, Jensen AD, Vilsbøll T.

Regul Pept. 2004 Jul 15;119(3):151-4.PMID: 15120474 [PubMed - indexed for MEDLINE]Related articles

Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1.

Ugleholdt R, Zhu X, Deacon CF, Ørskov C, Steiner DF, Holst JJ.

Endocrinology. 2004 Mar;145(3):1349-55. Epub 2003 Nov 20.PMID: 14630721 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide has tonic inhibitory effect, but is not involved in the vagal control or VIP effects on motility of the porcine antrum.

Schmidt PT, Orskov C, Rasmussen TN, Holst JJ.

Scand J Gastroenterol. 2003 Sep;38(9):955-61.PMID: 14531532 [PubMed - indexed for MEDLINE]Related articles

GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine.

Mortensen K, Christensen LL, Holst JJ, Orskov C.

Regul Pept. 2003 Jul 15;114(2-3):189-96.PMID: 12832109 [PubMed - indexed for MEDLINE]Related articles

Immunoneutralization of endogenous glucagon-like peptide-2 reduces adaptive intestinal growth in diabetic rats.

Hartmann B, Thulesen J, Hare KJ, Kissow H, Orskov C, Poulsen SS, Holst JJ.

Regul Pept. 2002 May 30;105(3):173-9.PMID: 11959371 [PubMed - indexed for MEDLINE]Related articles

The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist.

Thulesen J, Knudsen LB, Hartmann B, Hastrup S, Kissow H, Jeppesen PB, Ørskov C, Holst JJ, Poulsen SS.

Regul Pept. 2002 Jan 15;103(1):9-15.PMID: 11738243 [PubMed - indexed for MEDLINE]Related articles

Incretin hormones--an update.

Holst JJ, Orskov C.

Scand J Clin Lab Invest Suppl. 2001;234:75-85. Review.PMID: 11713984 [PubMed - indexed for MEDLINE]Related articles

A processing enzyme cleaving avian progastrin at post-Phe bonds.

Jensen H, Ørskov C, Rehfeld JF, Johnsen AH.

Biochim Biophys Acta. 2001 May 5;1547(1):64-71.PMID: 11343792 [PubMed - indexed for MEDLINE]Related articles

Intestinal growth adaptation and glucagon-like peptide 2 in rats with ileal--jejunal transposition or small bowel resection.

Thulesen J, Hartmann B, Kissow H, Jeppesen PB, Orskov C, Holst JJ, Poulsen SS.

Dig Dis Sci. 2001 Feb;46(2):379-88.PMID: 11281189 [PubMed - indexed for MEDLINE]Related articles

Pharmacological evidence for CGRP uptake into perivascular capsaicin sensitive nerve terminals.

Sams-Nielsen A, Orskov C, Jansen-Olesen I.

Br J Pharmacol. 2001 Mar;132(5):1145-53.PMID: 11226146 [PubMed - indexed for MEDLINE]Related articlesFree article

Colocalization of GLP-1 and GIP in human and porcine intestine.

Mortensen K, Petersen LL, Ørskov C.

Ann N Y Acad Sci. 2000;921:469-72. No abstract available. PMID: 11193878 [PubMed - indexed for MEDLINE]Related articles

Dipeptidyl peptidase IV inhibition enhances the intestinotrophic effect of glucagon-like peptide-2 in rats and mice.

Hartmann B, Thulesen J, Kissow H, Thulesen S, Orskov C, Ropke C, Poulsen SS, Holst JJ.

Endocrinology. 2000 Nov;141(11):4013-20.PMID: 11089531 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential targets for glucagon-like peptide 2 (GLP-2) in the rat: distribution and binding of i.v. injected (125)I-GLP-2.

Thulesen J, Hartmann B, Orskov C, Jeppesen PB, Holst JJ, Poulsen SS.

Peptides. 2000 Oct;21(10):1511-7.PMID: 11068098 [PubMed - indexed for MEDLINE]Related articles

Structure, measurement, and secretion of human glucagon-like peptide-2.

Hartmann B, Johnsen AH, Orskov C, Adelhorst K, Thim L, Holst JJ.

Peptides. 2000 Jan;21(1):73-80.PMID: 10704722 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine.

Hansen L, Deacon CF, Orskov C, Holst JJ.

Endocrinology. 1999 Nov;140(11):5356-63.PMID: 10537167 [PubMed - indexed for MEDLINE]Related articlesFree article

Normalization of fasting glycaemia by intravenous GLP-1 ([7-36 amide] or [7-37]) in type 2 diabetic patients.

Nauck MA, Weber I, Bach I, Richter S, Orskov C, Holst JJ, Schmiegel W.

Diabet Med. 1998 Nov;15(11):937-45.PMID: 9827848 [PubMed - indexed for MEDLINE]Related articles

Constitutive activity of glucagon receptor mutants.

Hjorth SA, Orskov C, Schwartz TW.

Mol Endocrinol. 1998 Jan;12(1):78-86.PMID: 9440812 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans.

Nauck MA, Niedereichholz U, Ettler R, Holst JJ, Orskov C, Ritzel R, Schmiegel WH.

Am J Physiol. 1997 Nov;273(5 Pt 1):E981-8.PMID: 9374685 [PubMed - indexed for MEDLINE]Related articlesFree article

Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem.

Larsen PJ, Tang-Christensen M, Holst JJ, Orskov C.

Neuroscience. 1997 Mar;77(1):257-70.PMID: 9044391 [PubMed - indexed for MEDLINE]Related articles

Short-term insulin treatment prevents the diabetogenic action of streptozotocin in rats.

Thulesen J, Orskov C, Holst JJ, Poulsen SS.

Endocrinology. 1997 Jan;138(1):62-8.PMID: 8977386 [PubMed - indexed for MEDLINE]Related articlesFree article

On the effects of glucagon-like peptide-1 on blood glucose regulation in normal and diabetic subjects.

Holst JJ, Toft-Nielsen MB, Orskov C, Nauck M, Willms B.

Ann N Y Acad Sci. 1996 Dec 26;805:729-36. Review. No abstract available. PMID: 8993469 [PubMed - indexed for MEDLINE]Related articles

Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM.

Nauck MA, Wollschläger D, Werner J, Holst JJ, Orskov C, Creutzfeldt W, Willms B.

Diabetologia. 1996 Dec;39(12):1546-53.PMID: 8960841 [PubMed - indexed for MEDLINE]Related articles

GLP-1 does not not acutely affect insulin sensitivity in healthy man.

Orskov L, Holst JJ, Møller J, Orskov C, Møller N, Alberti KG, Schmitz O.

Diabetologia. 1996 Oct;39(10):1227-32.PMID: 8897012 [PubMed - indexed for MEDLINE]Related articles

Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day.

Orskov C, Wettergren A, Holst JJ.

Scand J Gastroenterol. 1996 Jul;31(7):665-70.PMID: 8819215 [PubMed - indexed for MEDLINE]Related articles

Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients.

Creutzfeldt WO, Kleine N, Willms B, Orskov C, Holst JJ, Nauck MA.

Diabetes Care. 1996 Jun;19(6):580-6.PMID: 8725855 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I.

Orskov C, Poulsen SS, Møller M, Holst JJ.

Diabetes. 1996 Jun;45(6):832-5.PMID: 8635662 [PubMed - indexed for MEDLINE]Related articles

Release of glucagon-like peptide 1 (GLP-1 [7-36 amide]), gastric inhibitory polypeptide (GIP) and insulin in response to oral glucose after upper and lower intestinal resections.

Nauck MA, Siemsglüss J, Orskov C, Holst JJ.

Z Gastroenterol. 1996 Mar;34(3):159-66.PMID: 8650968 [PubMed - indexed for MEDLINE]Related articles

Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients.

Willms B, Werner J, Holst JJ, Orskov C, Creutzfeldt W, Nauck MA.

J Clin Endocrinol Metab. 1996 Jan;81(1):327-32.PMID: 8550773 [PubMed - indexed for MEDLINE]Related articles

Glucagon-like peptide 1 (7-36 amide) secretion in response to luminal sucrose from the upper and lower gut. A study using alpha-glucosidase inhibition (acarbose).

Qualmann C, Nauck MA, Holst JJ, Orskov C, Creutzfeldt W.

Scand J Gastroenterol. 1995 Sep;30(9):892-6.PMID: 8578189 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetic, insulinotropic, and glucagonostatic properties of GLP-1 [7-36 amide] after subcutaneous injection in healthy volunteers. Dose-response-relationships.

Ritzel R, Orskov C, Holst JJ, Nauck MA.

Diabetologia. 1995 Jun;38(6):720-5.PMID: 7672496 [PubMed - indexed for MEDLINE]Related articles

Physiological augmentation of amino acid-induced insulin secretion by GIP and GLP-I but not by CCK-8.

Fieseler P, Bridenbaugh S, Nustede R, Martell J, Orskov C, Holst JJ, Nauck MA.

Am J Physiol. 1995 May;268(5 Pt 1):E949-55.PMID: 7762650 [PubMed - indexed for MEDLINE]Related articles

Insulinotropic actions of intravenous glucagon-like peptide-1 (GLP-1) [7-36 amide] in the fasting state in healthy subjects.

Qualmann C, Nauck MA, Holst JJ, Orskov C, Creutzfeldt W.

Acta Diabetol. 1995 Mar;32(1):13-6.PMID: 7612912 [PubMed - indexed for MEDLINE]Related articles

Proglucagon processing in porcine and human pancreas.

Holst JJ, Bersani M, Johnsen AH, Kofod H, Hartmann B, Orskov C.

J Biol Chem. 1994 Jul 22;269(29):18827-33.PMID: 8034635 [PubMed - indexed for MEDLINE]Related articlesFree article