PubMed

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice.

Rhein V, Song X, Wiesner A, Ittner LM, Baysang G, Meier F, Ozmen L, Bluethmann H, Dröse S, Brandt U, Savaskan E, Czech C, Götz J, Eckert A.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20057-62. Epub 2009 Nov 6.PMID: 19897719 [PubMed - in process]Related articlesFree article

The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system.

Bradaia A, Trube G, Stalder H, Norcross RD, Ozmen L, Wettstein JG, Pinard A, Buchy D, Gassmann M, Hoener MC, Bettler B.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20081-6. Epub 2009 Nov 5.PMID: 19892733 [PubMed - in process]Related articles

Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice.

Grueninger F, Bohrmann B, Czech C, Ballard TM, Frey JR, Weidensteiner C, von Kienlin M, Ozmen L.

Neurobiol Dis. 2009 Sep 23. [Epub ahead of print]PMID: 19781645 [PubMed - as supplied by publisher]Related articles

Pharmacological characterization of senktide-induced tail whips.

Nordquist RE, Ballard TM, Algeyer B, Pauly-Evers M, Ozmen L, Spooren W.

Neuropharmacology. 2010 Jan;58(1):259-67. Epub 2009 Jun 21.PMID: 19540857 [PubMed - in process]Related articles

Expression of transgenic APP mRNA is the key determinant for beta-amyloid deposition in PS2APP transgenic mice.

Ozmen L, Albientz A, Czech C, Jacobsen H.

Neurodegener Dis. 2009;6(1-2):29-36. Epub 2008 Nov 5.PMID: 19066434 [PubMed - indexed for MEDLINE]Related articles

Characterization of behavioral response to amphetamine, tyrosine hydroxylase levels, and dopamine receptor levels in neurokinin 3 receptor knockout mice.

Nordquist RE, Savignac H, Pauly-Evers M, Walker G, Knoflach F, Borroni E, Glaentzlin P, Bohrmann B, Messer J, Ozmen L, Albientz A, Spooren W.

Behav Pharmacol. 2008 Sep;19(5-6):518-29.PMID: 18690106 [PubMed - indexed for MEDLINE]Related articles

Cognitive performance in neurokinin 3 receptor knockout mice.

Nordquist RE, Delenclos M, Ballard TM, Savignac H, Pauly-Evers M, Ozmen L, Spooren W.

Psychopharmacology (Berl). 2008 Jun;198(2):211-20. Epub 2008 Mar 20.PMID: 18351324 [PubMed - indexed for MEDLINE]Related articles

Trace amine-associated receptor 1 modulates dopaminergic activity.

Lindemann L, Meyer CA, Jeanneau K, Bradaia A, Ozmen L, Bluethmann H, Bettler B, Wettstein JG, Borroni E, Moreau JL, Hoener MC.

J Pharmacol Exp Ther. 2008 Mar;324(3):948-56. Epub 2007 Dec 14.PMID: 18083911 [PubMed - indexed for MEDLINE]Related articlesFree article

Substituted 2-oxo-azepane derivatives are potent, orally active gamma-secretase inhibitors.

Kitas EA, Galley G, Jakob-Roetne R, Flohr A, Wostl W, Mauser H, Alker AM, Czech C, Ozmen L, David-Pierson P, Reinhardt D, Jacobsen H.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):304-8. Epub 2007 Nov 5.PMID: 17983746 [PubMed - indexed for MEDLINE]Related articles

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.

Page RM, Baumann K, Tomioka M, Pérez-Revuelta BI, Fukumori A, Jacobsen H, Flohr A, Luebbers T, Ozmen L, Steiner H, Haass C.

J Biol Chem. 2008 Jan 11;283(2):677-83. Epub 2007 Oct 24.PMID: 17962197 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel orally active, dibenzazepinone-based gamma-secretase inhibitors.

Peters JU, Galley G, Jacobsen H, Czech C, David-Pierson P, Kitas EA, Ozmen L.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):5918-23. Epub 2007 Aug 22.PMID: 17869099 [PubMed - indexed for MEDLINE]Related articles

EVA regulates thymic stromal organisation and early thymocyte development.

DeMonte L, Porcellini S, Tafi E, Sheridan J, Gordon J, Depreter M, Blair N, Panigada M, Sanvito F, Merati B, Albientz A, Barthlott T, Ozmen L, Blackburn CC, Guttinger M.

Biochem Biophys Res Commun. 2007 May 4;356(2):334-40. Epub 2007 Mar 5.PMID: 17362876 [PubMed - indexed for MEDLINE]Related articles

BACE/APPV717F double-transgenic mice develop cerebral amyloidosis and inflammation.

Ozmen L, Woolley M, Albientz A, Miss MT, Nelboeck P, Malherbe P, Czech C, Gruninger-Leitch F, Brockhaus M, Ballard T, Jacobsen H.

Neurodegener Dis. 2005;2(6):284-98.PMID: 16909011 [PubMed - indexed for MEDLINE]Related articles

Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice.

Freichel C, Neumann M, Ballard T, Müller V, Woolley M, Ozmen L, Borroni E, Kretzschmar HA, Haass C, Spooren W, Kahle PJ.

Neurobiol Aging. 2007 Sep;28(9):1421-35. Epub 2006 Jul 26.PMID: 16872721 [PubMed - indexed for MEDLINE]Related articles

Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span.

von Kienlin M, Künnecke B, Metzger F, Steiner G, Richards JG, Ozmen L, Jacobsen H, Loetscher H.

Neurobiol Dis. 2005 Feb;18(1):32-9.PMID: 15649694 [PubMed - indexed for MEDLINE]Related articles

Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition.

Spooren W, Mombereau C, Maco M, Gill R, Kemp JA, Ozmen L, Nakanishi S, Higgins GA.

Psychopharmacology (Berl). 2004 Aug;175(1):99-105. Epub 2004 Feb 20.PMID: 14985927 [PubMed - indexed for MEDLINE]Related articles

PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.

Richards JG, Higgins GA, Ouagazzal AM, Ozmen L, Kew JN, Bohrmann B, Malherbe P, Brockhaus M, Loetscher H, Czech C, Huber G, Bluethmann H, Jacobsen H, Kemp JA.

J Neurosci. 2003 Oct 1;23(26):8989-9003.PMID: 14523101 [PubMed - indexed for MEDLINE]Related articlesFree article

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies.

Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Müller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C.

J Clin Invest. 2002 Nov;110(10):1429-39.PMID: 12438441 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes.

Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin WB, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar HA, Haass C.

EMBO Rep. 2002 Jun;3(6):583-8. Epub 2002 May 24.PMID: 12034752 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets: possible application of the thrombin inhibitor melagatran in clinical islet transplantation.

Ozmen L, Ekdahl KN, Elgue G, Larsson R, Korsgren O, Nilsson B.

Diabetes. 2002 Jun;51(6):1779-84.PMID: 12031965 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model.

Kahle PJ, Neumann M, Ozmen L, Müller V, Odoy S, Okamoto N, Jacobsen H, Iwatsubo T, Trojanowski JQ, Takahashi H, Wakabayashi K, Bogdanovic N, Riederer P, Kretzschmar HA, Haass C.

Am J Pathol. 2001 Dec;159(6):2215-25.PMID: 11733371 [PubMed - indexed for MEDLINE]Related articlesFree article

Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice.

Rathke-Hartlieb S, Kahle PJ, Neumann M, Ozmen L, Haid S, Okochi M, Haass C, Schulz JB.

J Neurochem. 2001 May;77(4):1181-4.PMID: 11359883 [PubMed - indexed for MEDLINE]Related articles

Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.

Kahle PJ, Neumann M, Ozmen L, Haass C.

Ann N Y Acad Sci. 2000;920:33-41. Review.PMID: 11193173 [PubMed - indexed for MEDLINE]Related articles

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain.

Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Schindzielorz A, Okochi M, Leimer U, van Der Putten H, Probst A, Kremmer E, Kretzschmar HA, Haass C.

J Neurosci. 2000 Sep 1;20(17):6365-73.PMID: 10964942 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-18 stimulates HIV-1 replication in a T-cell line.

Klein SA, Klebba C, Kauschat D, Pape M, Ozmen L, Hoelzer D, Ottmann OG, Kalina U.

Eur Cytokine Netw. 2000 Mar;11(1):47-52.PMID: 10705298 [PubMed - indexed for MEDLINE]Related articles

Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock.

Mattner F, Ozmen L, Podlaski FJ, Wilkinson VL, Presky DH, Gately MK, Alber G.

Infect Immun. 1997 Nov;65(11):4734-7.PMID: 9353058 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression and role in apoptosis of the alpha- and beta-chains of the IFN-gamma receptor on human Th1 and Th2 clones.

Novelli F, D'Elios MM, Bernabei P, Ozmen L, Rigamonti L, Almerigogna F, Forni G, Del Prete G.

J Immunol. 1997 Jul 1;159(1):206-13.PMID: 9200456 [PubMed - indexed for MEDLINE]Related articles

Mouse macrophages carrying both subunits of the human interferon-gamma (IFN-gamma) receptor respond to human IFN-gamma but do not acquire full protection against viral cytopathic effect.

Lembo D, Ricciardi-Castagnoli P, Alber G, Ozmen L, Landolfo S, Blüthmann H, Dembic Z, Kotenko SV, Cook JR, Pestka S, Garotta G.

J Biol Chem. 1996 Dec 20;271(51):32659-66.PMID: 8955096 [PubMed - indexed for MEDLINE]Related articlesFree article

Switching on of the proliferation or apoptosis of activated human T lymphocytes by IFN-gamma is correlated with the differential expression of the alpha- and beta-chains of its receptor.

Novelli F, Bernabei P, Ozmen L, Rigamonti L, Allione A, Pestka S, Garotta G, Forni G.

J Immunol. 1996 Sep 1;157(5):1935-43.PMID: 8757312 [PubMed - indexed for MEDLINE]Related articles

The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon.

Ozmen L, Aguet M, Trinchieri G, Garotta G.

J Virol. 1995 Dec;69(12):8147-50.PMID: 7494339 [PubMed - indexed for MEDLINE]Related articlesFree article

Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice.

Wysocka M, Kubin M, Vieira LQ, Ozmen L, Garotta G, Scott P, Trinchieri G.

Eur J Immunol. 1995 Mar;25(3):672-6.PMID: 7705395 [PubMed - indexed for MEDLINE]Related articles

Experimental therapy of systemic lupus erythematosus: the treatment of NZB/W mice with mouse soluble interferon-gamma receptor inhibits the onset of glomerulonephritis.

Ozmen L, Roman D, Fountoulakis M, Schmid G, Ryffel B, Garotta G.

Eur J Immunol. 1995 Jan;25(1):6-12.PMID: 7843255 [PubMed - indexed for MEDLINE]Related articles

Soluble interferon-gamma receptor: a therapeutically useful drug for systemic lupus erythematosus.

Ozmen L, Roman D, Fountoulakis M, Schmid G, Ryffel B, Garotta G.

J Interferon Res. 1994 Oct;14(5):283-4. No abstract available. PMID: 7861031 [PubMed - indexed for MEDLINE]Related articles

Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction.

Ozmen L, Pericin M, Hakimi J, Chizzonite RA, Wysocka M, Trinchieri G, Gately M, Garotta G.

J Exp Med. 1994 Sep 1;180(3):907-15.PMID: 7914909 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum amyloid protein (SAP) as a marker of autoimmune disease in mice.

Ozmen L, Singer M, Garotta G.

J Biol Regul Homeost Agents. 1994 Jul-Sep;8(3):92-8.PMID: 7754795 [PubMed - indexed for MEDLINE]Related articles

Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.

Igarashi K, Garotta G, Ozmen L, Ziemiecki A, Wilks AF, Harpur AG, Larner AC, Finbloom DS.

J Biol Chem. 1994 May 20;269(20):14333-6.PMID: 7514165 [PubMed - indexed for MEDLINE]Related articlesFree article

Interferon gamma receptor deficient mice are resistant to endotoxic shock.

Car BD, Eng VM, Schnyder B, Ozmen L, Huang S, Gallay P, Heumann D, Aguet M, Ryffel B.

J Exp Med. 1994 May 1;179(5):1437-44.PMID: 8163930 [PubMed - indexed for MEDLINE]Related articlesFree article

Mouse soluble IFN gamma receptor as IFN gamma inhibitor. Distribution, antigenicity, and activity after injection in mice.

Ozmen L, Gribaudo G, Fountoulakis M, Gentz R, Landolfo S, Garotta G.

J Immunol. 1993 Apr 1;150(7):2698-705.PMID: 8454850 [PubMed - indexed for MEDLINE]Related articles

The human gamma interferon receptor accessory factor encoded by chromosome 21 transduces the signal for the induction of 2',5'-oligoadenylate-synthetase, resistance to virus cytopathic effect, and major histocompatibility complex class I antigens.

Kalina U, Ozmen L, Di Padova K, Gentz R, Garotta G.

J Virol. 1993 Mar;67(3):1702-6.PMID: 8437239 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunomodulation with soluble IFN-gamma receptor: preliminary study.

Ozmen L, Fountoulakis M, Gentz R, Garotta G.

Int Rev Exp Pathol. 1993;34 Pt B:137-47.PMID: 8458710 [PubMed - indexed for MEDLINE]Related articles

IFN-gamma receptor-Ig fusion proteins. Half-life, immunogenicity, and in vivo activity.

Kürschner C, Ozmen L, Garotta G, Dembic Z.

J Immunol. 1992 Dec 15;149(12):4096-100.PMID: 1460292 [PubMed - indexed for MEDLINE]Related articles

Analysis of soluble human and mouse interferon-gamma receptors expressed in eukaryotic cells.

Gentz R, Hayes A, Grau N, Fountoulakis M, Lahm HW, Ozmen L, Garotta G.

Eur J Biochem. 1992 Dec 1;210(2):545-54.PMID: 1459135 [PubMed - indexed for MEDLINE]Related articlesFree article

Distribution of interferon-gamma receptor in human tissues.

Valente G, Ozmen L, Novelli F, Geuna M, Palestro G, Forni G, Garotta G.

Eur J Immunol. 1992 Sep;22(9):2403-12.PMID: 1387613 [PubMed - indexed for MEDLINE]Related articles

A novel solid-phase test to study the binding of IFN-gamma to its receptor.

Ozmen L, Fountoulakis M, Garotta G.

J Immunol Methods. 1992 Mar 4;147(2):261-70.PMID: 1372336 [PubMed - indexed for MEDLINE]Related articles

Purification and biochemical characterization of a soluble mouse interferon-gamma receptor produced in insect cells.

Fountoulakis M, Schlaeger EJ, Gentz R, Juranville JF, Manneberg M, Ozmen L, Garotta G.

Eur J Biochem. 1991 Jun 1;198(2):441-50.PMID: 1828230 [PubMed - indexed for MEDLINE]Related articlesFree article

High-affinity receptor for interferon-gamma (IFN-gamma), a ubiquitous protein occurring in different molecular forms on human cells: blood monocytes and eleven different cell lines have the same IFN-gamma receptor protein.

van Loon AP, Ozmen L, Fountoulakis M, Kania M, Haiker M, Garotta G.

J Leukoc Biol. 1991 May;49(5):462-73.PMID: 1826725 [PubMed - indexed for MEDLINE]Related articlesFree article

One interferon gamma receptor binds one interferon gamma dimer.

Fountoulakis M, Juranville JF, Maris A, Ozmen L, Garotta G.

J Biol Chem. 1990 Nov 15;265(32):19758-67.PMID: 2147181 [PubMed - indexed for MEDLINE]Related articlesFree article

Human interferon-gamma receptor. Mapping of epitopes recognized by neutralizing antibodies using native and recombinant receptor proteins.

Garotta G, Ozmen L, Fountoulakis M, Dembic Z, van Loon AP, Stüber D.

J Biol Chem. 1990 Apr 25;265(12):6908-15.PMID: 1691178 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure and membrane topology of the high-affinity receptor for human IFN-gamma: requirements for binding IFN-gamma. One single 90-kilodalton IFN-gamma receptor can lead to multiple cross-linked products and isolated proteins.

Fountoulakis M, Kania M, Ozmen L, Loetscher HR, Garotta G, van Loon AP.

J Immunol. 1989 Nov 15;143(10):3266-76.PMID: 2530276 [PubMed - indexed for MEDLINE]Related articles

Development of interferon-gamma antagonists as an example of biotechnology application to approach new immunomodulators.

Garotta G, Ozmen L, Fountoulakis M.

Pharmacol Res. 1989 Nov-Dec;21 Suppl 2:5-17. Review.PMID: 2534322 [PubMed - indexed for MEDLINE]Related articles