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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1983 2
1984 7
1985 7
1986 11
1987 8
1988 4
1989 2
1990 8
1991 5
1992 7
1993 7
1994 6
1995 4
1996 11
1997 3
1998 8
1999 3
2000 8
2001 4
2002 5
2004 4
2005 1
2006 3
2007 3
2008 5
2009 2
2010 6
2011 4
2012 9
2013 9
2014 11
2015 10
2016 11
2017 12
2018 12
2019 12
2020 11
2021 9
2022 6
2023 7
2024 3

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248 results

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Page 1
The Emerging Neurobiology of Bipolar Disorder.
Harrison PJ, Geddes JR, Tunbridge EM. Harrison PJ, et al. Trends Neurosci. 2018 Jan;41(1):18-30. doi: 10.1016/j.tins.2017.10.006. Epub 2017 Nov 20. Trends Neurosci. 2018. PMID: 29169634 Free PMC article. Review.
Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown, and its treatment unsatisfactory. ...First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as par …
Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown, and its treatment unsat …
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.
Mullins N, Forstner AJ, O'Connell KS, Coombes B, Coleman JRI, Qiao Z, Als TD, Bigdeli TB, Børte S, Bryois J, Charney AW, Drange OK, Gandal MJ, Hagenaars SP, Ikeda M, Kamitaki N, Kim M, Krebs K, Panagiotaropoulou G, Schilder BM, Sloofman LG, Steinberg S, Trubetskoy V, Winsvold BS, Won HH, Abramova L, Adorjan K, Agerbo E, Al Eissa M, Albani D, Alliey-Rodriguez N, Anjorin A, Antilla V, Antoniou A, Awasthi S, Baek JH, Bækvad-Hansen M, Bass N, Bauer M, Beins EC, Bergen SE, Birner A, Bøcker Pedersen C, Bøen E, Boks MP, Bosch R, Brum M, Brumpton BM, Brunkhorst-Kanaan N, Budde M, Bybjerg-Grauholm J, Byerley W, Cairns M, Casas M, Cervantes P, Clarke TK, Cruceanu C, Cuellar-Barboza A, Cunningham J, Curtis D, Czerski PM, Dale AM, Dalkner N, David FS, Degenhardt F, Djurovic S, Dobbyn AL, Douzenis A, Elvsåshagen T, Escott-Price V, Ferrier IN, Fiorentino A, Foroud TM, Forty L, Frank J, Frei O, Freimer NB, Frisén L, Gade K, Garnham J, Gelernter J, Giørtz Pedersen M, Gizer IR, Gordon SD, Gordon-Smith K, Greenwood TA, Grove J, Guzman-Parra J, Ha K, Haraldsson M, Hautzinger M, Heilbronner U, Hellgren D, Herms S, Hoffmann P, Holmans PA, Huckins L, Jamain S, Johnson JS, Kalman JL, Kamatani Y, Kennedy… See abstract for full author list ➔ Mullins N, et al. Nat Genet. 2021 Jun;53(6):817-829. doi: 10.1038/s41588-021-00857-4. Epub 2021 May 17. Nat Genet. 2021. PMID: 34002096 Free PMC article.
Bipolar disorder is a heritable mental illness with complex etiology. ...Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating expression quantitative …
Bipolar disorder is a heritable mental illness with complex etiology. ...Significant signal enrichment was found in genes enco …
Innovative approaches to bipolar disorder and its treatment.
Harrison PJ, Cipriani A, Harmer CJ, Nobre AC, Saunders K, Goodwin GM, Geddes JR. Harrison PJ, et al. Ann N Y Acad Sci. 2016 Feb;1366(1):76-89. doi: 10.1111/nyas.13048. Ann N Y Acad Sci. 2016. PMID: 27111134 Free PMC article. Review.
All psychiatric disorders have suffered from a dearth of truly novel pharmacological interventions. In bipolar disorder, lithium remains a mainstay of treatment, six decades since its effects were serendipitously discovered. ...Third, genomic data can inform …
All psychiatric disorders have suffered from a dearth of truly novel pharmacological interventions. In bipolar disorder, lithi …
Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale.
Hong JSW, Atkinson LZ, Al-Juffali N, Awad A, Geddes JR, Tunbridge EM, Harrison PJ, Cipriani A. Hong JSW, et al. Mol Psychiatry. 2022 Mar;27(3):1339-1349. doi: 10.1038/s41380-021-01386-6. Epub 2021 Nov 24. Mol Psychiatry. 2022. PMID: 34819636 Free PMC article.
For bipolar disorder, four double-blind RCTs investigating gabapentin, and no double-blind RCTs investigating pregabalin, were identified. ...This recommendation applies despite the attractive pharmacological and genetic rationale for targeting voltage-gated calc …
For bipolar disorder, four double-blind RCTs investigating gabapentin, and no double-blind RCTs investigating pregabalin, were …
Non-canonical pathways in the pathophysiology and therapeutics of bipolar disorder.
Machado-Vieira R, Courtes AC, Zarate CA Jr, Henter ID, Manji HK. Machado-Vieira R, et al. Front Neurosci. 2023 Aug 1;17:1228455. doi: 10.3389/fnins.2023.1228455. eCollection 2023. Front Neurosci. 2023. PMID: 37592949 Free PMC article. Review.
Bipolar disorder (BD) is characterized by extreme mood swings ranging from manic/hypomanic to depressive episodes. ...This article reviews different neurobiological targets and pathophysiological findings in non-canonical pathways in BD that may offer opportunities …
Bipolar disorder (BD) is characterized by extreme mood swings ranging from manic/hypomanic to depressive episodes. ...This art …
[Nimodipine in treatment of bipolar disorder].
Romanov DV, Sheyanov AM, Samsonova MD, Iuzbashian PG. Romanov DV, et al. Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123(12):20-26. doi: 10.17116/jnevro202312312120. Zh Nevrol Psikhiatr Im S S Korsakova. 2023. PMID: 38147378 Review. Russian.
The article discusses the prospects for using the calcium channel blocker nimodipine as a method of both mono and combination therapy for bipolar disorders with various types of course. Nimodipine is a selective blocker of voltage-depende …
The article discusses the prospects for using the calcium channel blocker nimodipine as a method of both mono and combi …
Applications of calcium channel blockers in psychiatry: pharmacokinetic and pharmacodynamic aspects of treatment of bipolar disorder.
Dubovsky SL. Dubovsky SL. Expert Opin Drug Metab Toxicol. 2019 Jan;15(1):35-47. doi: 10.1080/17425255.2019.1558206. Epub 2018 Dec 17. Expert Opin Drug Metab Toxicol. 2019. PMID: 30558453 Review.
Evidence of hyperactive intracellular calcium ion signaling in multiple peripheral cells of patients with bipolar disorder, calcium antagonist actions of established mood stabilizers, and a relative dearth of treatments have prompted research in …
Evidence of hyperactive intracellular calcium ion signaling in multiple peripheral cells of patients with bipolar disorder …
Allopurinol, dipyridamole and calcium channel blockers in the treatment of bipolar disorder - A nationwide cohort study.
Lintunen J, Lähteenvuo M, Tanskanen A, Tiihonen J, Taipale H. Lintunen J, et al. J Affect Disord. 2022 Sep 15;313:43-48. doi: 10.1016/j.jad.2022.06.040. Epub 2022 Jun 23. J Affect Disord. 2022. PMID: 35753501 Free article.
BACKGROUND: Improved treatments for bipolar disorder (BD) are needed. Drug repurposing aims to find novel targets for drugs that have been used for other indications. This study investigated the risk of psychiatric hospitalization associated with use of ca …
BACKGROUND: Improved treatments for bipolar disorder (BD) are needed. Drug repurposing aims to find novel targets for d …
Calcium Channel Antagonists for Mood Disorders.
Dubovsky SL, Marshall D. Dubovsky SL, et al. J Clin Psychopharmacol. 2022 Mar-Apr 01;42(2):188-197. doi: 10.1097/JCP.0000000000001534. J Clin Psychopharmacol. 2022. PMID: 35185116 Review.
After summarizing studies of calcium channel blocking agents, whose primary action is to attenuate hyperactive intracellular calcium signaling, we considered clinical experience with this class of medications and the potential for further research. FINDINGS: …
After summarizing studies of calcium channel blocking agents, whose primary action is to attenuate hyperactive intracellular …
Beyond evidence-based treatment of bipolar disorder: Rational pragmatic approaches to management.
Post RM, Yatham LN, Vieta E, Berk M, Nierenberg AA. Post RM, et al. Bipolar Disord. 2019 Nov;21(7):650-659. doi: 10.1111/bdi.12813. Epub 2019 Aug 19. Bipolar Disord. 2019. PMID: 31343802 Free PMC article. Review.
The evidence for efficacy of many currently available treatments for bipolar disorder is based on studies of nonrefractory patients with bipolar disorder. Therefore, not surprisingly, most treatment recommendations and guidelines for the …
The evidence for efficacy of many currently available treatments for bipolar disorder is based on studies of nonrefract …
248 results