The drugs under study may be disposed as follows according to the efficiency of postoperative epidural anesthesia: pyromecain, clophelin, trimecain-albumin complex. Most effective are clophelin and trimecain-albumin complex. All the three drugs exert an inconsiderable influence on indices of central hemodynamics. The use of clophelin and trimecain-albumin complex reduces loading the medical personnel. Clophelin is most expedient economically.