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Blood Levels of Ammonia and Carnitine in Patients Treated with Valproic Acid: A Meta-analysis.
Yokoyama S, Sugawara N, Maruo K, Yasui-Furukori N, Shimoda K. Yokoyama S, et al. Clin Psychopharmacol Neurosci. 2022 Aug 31;20(3):536-547. doi: 10.9758/cpn.2022.20.3.536. Clin Psychopharmacol Neurosci. 2022. PMID: 35879038 Free PMC article.
OBJECTIVE: Long-term valproic acid (VPA) administration is associated with adverse metabolic effects, including hyperammonemia and hypocarnitinemia. ...Furthermore, the blood ammonia level was moderately correlated with the blood free carnitine level. …
OBJECTIVE: Long-term valproic acid (VPA) administration is associated with adverse metabolic effects, including hyperammonemia …
Valproic acid induced liver injury: An insight into molecular toxicological mechanism.
Ezhilarasan D, Mani U. Ezhilarasan D, et al. Environ Toxicol Pharmacol. 2022 Oct;95:103967. doi: 10.1016/j.etap.2022.103967. Epub 2022 Sep 1. Environ Toxicol Pharmacol. 2022. PMID: 36058508 Review.
Valproic acid (VPA) is an anti-seizure drug that causes idiosyncratic liver injury. 2-propyl-4-pentenoic acid (delta(4)VPA), a metabolite of VPA, has been implicated in VPA-induced hepatotoxicity. ...The VPA induce liver injury mainly by i) liberation of delt …
Valproic acid (VPA) is an anti-seizure drug that causes idiosyncratic liver injury. 2-propyl-4-pentenoic acid (delta(4) …
Association Between the Serum Carnitine Level and Ammonia and Valproic Acid Levels in Patients with Bipolar Disorder.
Yokoyama S, Yasui-Furukori N, Nakagami T, Miyazaki K, Ishioka M, Tarakita N, Kubo K, Sugawara N, Shimoda K. Yokoyama S, et al. Ther Drug Monit. 2020 Oct;42(5):766-770. doi: 10.1097/FTD.0000000000000778. Ther Drug Monit. 2020. PMID: 32482992
PURPOSE: Valproic acid (VPA) is not only an antiepileptic drug but also a mood stabilizer for patients with bipolar disorder. Long-term VPA therapy can cause carnitine deficiency, which may result in an increase in the blood ammonia level, in patients …
PURPOSE: Valproic acid (VPA) is not only an antiepileptic drug but also a mood stabilizer for patients with bipolar disorder. …
Valproic Acid-Associated Hyperammonemia: A Systematic Review.
Wong YJ, Fan J, Wan A, Mihic T, Gnyra M. Wong YJ, et al. J Clin Psychopharmacol. 2023 May-Jun 01;43(3):283-294. doi: 10.1097/JCP.0000000000001689. J Clin Psychopharmacol. 2023. PMID: 37126830
BACKGROUND: Hyperammonemia is an adverse effect that poses clinical uncertainty around valproic acid (VPA) use. The prevalence of symptomatic and asymptomatic hyperammonemia and its relationship to VPA concentration is not well established. ...There was insufficient …
BACKGROUND: Hyperammonemia is an adverse effect that poses clinical uncertainty around valproic acid (VPA) use. The prevalence …
Quantitative systems pharmacology Model to characterize valproic acid-induced hyperammonemia and the effect of L-carnitine supplementation.
Schiavo A, Maldonado C, Vázquez M, Fagiolino P, Trocóniz IF, Ibarra M. Schiavo A, et al. Eur J Pharm Sci. 2023 Apr 1;183:106399. doi: 10.1016/j.ejps.2023.106399. Epub 2023 Feb 4. Eur J Pharm Sci. 2023. PMID: 36740101 Free article.
Valproic acid (VPA) is a short-chain fatty acid widely prescribed in the treatment of seizure disorders and epilepsy syndromes, although its therapeutic value may be undermined by its toxicity. ...Results show that a L-carnitine dose equal to the doubl …
Valproic acid (VPA) is a short-chain fatty acid widely prescribed in the treatment of seizure disorders and epilepsy sy …
Effects of levetiracetam and valproic acid treatment on liver function tests, plasma free carnitine and lipid peroxidation in childhood epilepsies.
Haznedar P, Doğan Ö, Albayrak P, Öz Tunçer G, Teber S, Deda G, Eminoglu FT. Haznedar P, et al. Epilepsy Res. 2019 Jul;153:7-13. doi: 10.1016/j.eplepsyres.2019.03.009. Epub 2019 Mar 15. Epilepsy Res. 2019. PMID: 30925397
In our study, we investigated oxidative stress parameters, carnitine levels, liver function tests (LFT) and their relationship in epileptic children treated with valproic acid or levetiracetam. ...Carnitine levels were significantly low in patients und …
In our study, we investigated oxidative stress parameters, carnitine levels, liver function tests (LFT) and their relationship in epi …
Carnitine in Alleviation of Complications Caused by Acute Valproic Acid Toxicity; an Exprimental Study on Mice.
Jamshidzadeh A, Heidari R, Shams M, Ebrahimi-Sharghi M, Marashi SM. Jamshidzadeh A, et al. Arch Acad Emerg Med. 2023 Dec 28;12(1):e20. doi: 10.22037/aaem.v12i1.2146. eCollection 2024. Arch Acad Emerg Med. 2023. PMID: 38371450 Free PMC article.
INTRODUCTION: Hyperammonemia and hepatotoxicity are well-known complications of valproic acid (VPA) poisoning. The objective of this study is to evaluate the potential role of carnitine in mitigating the adverse effects of acute VPA toxicity in mice. ...The a …
INTRODUCTION: Hyperammonemia and hepatotoxicity are well-known complications of valproic acid (VPA) poisoning. The objective o …
Effects of l-carnitine supplementation in patients with childhood-onset epilepsy prescribed valproate.
Okumura A, Takagi M, Numoto S, Iwayama H, Azuma Y, Kurahashi H. Okumura A, et al. Epilepsy Behav. 2021 Sep;122:108220. doi: 10.1016/j.yebeh.2021.108220. Epub 2021 Aug 7. Epilepsy Behav. 2021. PMID: 34371461
Therefore, we retrospectively explored the benefits of carnitine supplementation by analyzing laboratory data. METHODS: We measured the serum-free carnitine (FC), VPA, aspartate aminotransferase, alanine aminotransferase, amylase, and ammonia levels, and the …
Therefore, we retrospectively explored the benefits of carnitine supplementation by analyzing laboratory data. METHODS: We measured t …
The role of efflux transporters and metabolizing enzymes in brain and peripheral organs to explain drug-resistant epilepsy.
Vázquez M, Fagiolino P. Vázquez M, et al. Epilepsia Open. 2022 Aug;7 Suppl 1(Suppl 1):S47-S58. doi: 10.1002/epi4.12542. Epub 2021 Oct 1. Epilepsia Open. 2022. PMID: 34560816 Free PMC article. Review.
Such induction is not only local drug concentration but also time dependent. In the case of valproic acid, the deficient disposition of ammonia due to a malfunction of the urea cycle, which would have its origin in an intrinsic deficiency of L-carnitine …
Such induction is not only local drug concentration but also time dependent. In the case of valproic acid, the deficient dispo …
Carnitine supplementation prevents carnitine deficiency caused by pivalate-conjugated antibiotics in patients with epilepsy prescribed valproate.
Okumura A, Numoto S, Iwayama H, Azuma Y, Kurahashi H. Okumura A, et al. Epilepsy Behav. 2021 Apr;117:107883. doi: 10.1016/j.yebeh.2021.107883. Epub 2021 Mar 11. Epilepsy Behav. 2021. PMID: 33714931
Carnitine deficiency due to PCA use was prevented by carnitine supplementation in patients with epilepsy who were taking VPA. Carnitine supplementation can support patients at risk of carnitine deficiency....
Carnitine deficiency due to PCA use was prevented by carnitine supplementation in patients with epilepsy who were taking VPA. …
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