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1973 2
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Inhibition of UDP-Glucuronosyltransferase Enzymes by Major Cannabinoids and Their Metabolites.
Nasrin S, Watson CJW, Bardhi K, Fort G, Chen G, Lazarus P. Nasrin S, et al. Drug Metab Dispos. 2021 Dec;49(12):1081-1089. doi: 10.1124/dmd.121.000530. Epub 2021 Sep 7. Drug Metab Dispos. 2021. PMID: 34493601
This inhibition of UGT activity suggests that in addition to playing an important role in drug-drug interactions, cannabinoid exposure may have important implications in patients with impaired hepatic or kidney function. ...This study is the first to show the potent …
This inhibition of UGT activity suggests that in addition to playing an important role in drug-drug interactions, cannabinoid …
Comparative Metabolomic Profiling of the Metabolic Differences of Δ9-Tetrahydrocannabinol and Cannabidiol.
Rao Q, Zhang T, Dai M, Li B, Pu Q, Zhao M, Cheng Y, Yan D, Zhao Q, Wu ZE, Li F. Rao Q, et al. Molecules. 2022 Nov 4;27(21):7573. doi: 10.3390/molecules27217573. Molecules. 2022. PMID: 36364400 Free PMC article.
More than one hundred cannabinoids have been found in cannabis. delta9-Tetrahydrocannabinol (THC) is the recognized addictive constituent in cannabis; however, the mechanisms underlying THC-induced toxicity remain elusive. To better understand cannabis-induced toxic …
More than one hundred cannabinoids have been found in cannabis. delta9-Tetrahydrocannabinol (THC) is the recognized addictive constituent in …
Comparative metabolism of THCA and THCV using UHPLC-Q-Exactive Orbitrap-MS.
Rao Q, Zhang T, Pu QL, Li B, Zhao Q, Yan DM, Wu ZE, Li F. Rao Q, et al. Xenobiotica. 2023 Jan;53(1):46-59. doi: 10.1080/00498254.2023.2194981. Epub 2023 Apr 10. Xenobiotica. 2023. PMID: 36951512
However, the relationship between the metabolic characterisation and bioactivity of THCA and THCV remains elusive.To explore the relationship between the metabolism of THCA and THCV and their underlying mechanism of activity, human/mouse liver microsomes and mouse primary …
However, the relationship between the metabolic characterisation and bioactivity of THCA and THCV remains elusive.To explore the relationshi …
The acute effect of cannabis on plasma, liver and brain ammonia dynamics, a translational study.
Abulseoud OA, Zuccoli ML, Zhang L, Barnes A, Huestis MA, Lin DT. Abulseoud OA, et al. Eur Neuropsychopharmacol. 2017 Jul;27(7):679-690. doi: 10.1016/j.euroneuro.2017.03.006. Epub 2017 Apr 26. Eur Neuropsychopharmacol. 2017. PMID: 28456476 Free PMC article. Clinical Trial.
To test the hypothesis that this delayed increase in plasma ammonia originates from the brain we administered THC (3 and 10mg/kg) to mice and measured plasma, liver, and brain ammonia concentrations at 1, 3, 5 and 30min post-injection. ...
To test the hypothesis that this delayed increase in plasma ammonia originates from the brain we administered THC (3 and 10mg/kg) to mice an …
Antifibrogenic role of the cannabinoid receptor CB2 in the liver.
Julien B, Grenard P, Teixeira-Clerc F, Van Nhieu JT, Li L, Karsak M, Zimmer A, Mallat A, Lotersztajn S. Julien B, et al. Gastroenterology. 2005 Mar;128(3):742-55. doi: 10.1053/j.gastro.2004.12.050. Gastroenterology. 2005. PMID: 15765409
Functional studies were performed in cultured hepatic myofibroblasts and activated hepatic stellate cells. Carbon tetrachloride-induced liver fibrosis was studied in mice invalidated for CB2 receptors. ...CONCLUSIONS: These data constitute the first demonstration th …
Functional studies were performed in cultured hepatic myofibroblasts and activated hepatic stellate cells. Carbon tetrachloride-induced …
Effects of delta-9-tetrahydrocannabinol on drug distribution and metabolism. Antipyrine, pentobarbital, and ethanol.
Benowitz NL, Jones RT. Benowitz NL, et al. Clin Pharmacol Ther. 1977 Sep;22(3):259-68. doi: 10.1002/cpt1977223259. Clin Pharmacol Ther. 1977. PMID: 891094
Delta-9-tetrahydrocannabinol (THC) has been reported to inhibit drug metabolism in animals. Twenty-two hospitalized healthy volunteer subjects received THC, 60 to 180 mg/day in divided doses for 14 days. ...This is consistent with THC effects of slowing intestinal motility …
Delta-9-tetrahydrocannabinol (THC) has been reported to inhibit drug metabolism in animals. Twenty-two hospitalized healthy volunteer …
delta8-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors.
Bátkai S, Mukhopadhyay P, Horváth B, Rajesh M, Gao RY, Mahadevan A, Amere M, Battista N, Lichtman AH, Gauson LA, Maccarrone M, Pertwee RG, Pacher P. Bátkai S, et al. Br J Pharmacol. 2012 Apr;165(8):2450-61. doi: 10.1111/j.1476-5381.2011.01410.x. Br J Pharmacol. 2012. PMID: 21470208 Free PMC article.
Hepatic I/R injury was assessed in mice with 1h ischaemia and 2, 6 or 24h reperfusion in vivo. ...Protective effects of delta(8) -THCV against liver damage were still present when the compound was given at the beginning of reperfusion. ...
Hepatic I/R injury was assessed in mice with 1h ischaemia and 2, 6 or 24h reperfusion in vivo. ...Protective effects of delta(8) -THC …
Long-Term Heavy Recreational Cannabis Use and Serum Delta-9-Tetrahydrocannabinol Levels are not Associated with an Impaired Liver Function in Cannabis Dependents.
Bonnet U, Canbay A, Specka M, Scherbaum N. Bonnet U, et al. J Psychoactive Drugs. 2018 Sep-Oct;50(4):355-360. doi: 10.1080/02791072.2018.1482031. Epub 2018 Jul 27. J Psychoactive Drugs. 2018. PMID: 30052163
Serum liver function tests (LFT: transaminases, bilirubin), C-reactive protein (CRP), carbohydrate-deficient transferrin (CDT), and body mass index (BMI) were considered. ...These results argue against a relevant harmful impact of chronic cannabis inhalation on the live …
Serum liver function tests (LFT: transaminases, bilirubin), C-reactive protein (CRP), carbohydrate-deficient transferrin (CDT), and b …
12 results