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Year Number of Results
1993 1
2000 1
2006 1
2014 2
2015 1
2016 1
2017 2
2018 22
2019 679
2020 1316
2021 1419
2022 1457
2023 1503
2024 663

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6,065 results

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Page 1
Pathogenesis and management of abdominal aortic aneurysm.
Golledge J, Thanigaimani S, Powell JT, Tsao PS. Golledge J, et al. Eur Heart J. 2023 Aug 1;44(29):2682-2697. doi: 10.1093/eurheartj/ehad386. Eur Heart J. 2023. PMID: 37387260 Free PMC article. Review.
Advances in AAA repair techniques have occurred, but a remaining priority is therapies to limit AAA growth and rupture. This review outlines research on AAA pathogenesis and therapies to limit AAA growth. Genome-wide association studies have identified …
Advances in AAA repair techniques have occurred, but a remaining priority is therapies to limit AAA growth and rupture. This r …
Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation.
Tian Z, Zhang Y, Zheng Z, Zhang M, Zhang T, Jin J, Zhang X, Yao G, Kong D, Zhang C, Wang Z, Zhang Q. Tian Z, et al. Cell Host Microbe. 2022 Oct 12;30(10):1450-1463.e8. doi: 10.1016/j.chom.2022.09.004. Cell Host Microbe. 2022. PMID: 36228585 Free article.
Gut microbiota dysbiosis plays key roles in many diseases, but its relationship with AAA has not been fully elucidated. Herein, we reveal significant abnormalities in the gut microbe composition of AAA patients and confirm that gut microbiota dysbiosis is an importa …
Gut microbiota dysbiosis plays key roles in many diseases, but its relationship with AAA has not been fully elucidated. Herein, we re …
Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2.
Sun LY, Lyu YY, Zhang HY, Shen Z, Lin GQ, Geng N, Wang YL, Huang L, Feng ZH, Guo X, Lin N, Ding S, Yuan AC, Zhang L, Qian K, Pu J. Sun LY, et al. Circulation. 2022 Nov 22;146(21):1591-1609. doi: 10.1161/CIRCULATIONAHA.121.057623. Epub 2022 Jul 26. Circulation. 2022. PMID: 35880522 Free PMC article.
However, the role of NRs in AAA development remains largely unknown. METHODS: We analyzed the expression profile of the NR superfamily in AAA tissues and identified NR1D1 (NR subfamily 1 group D member 1) as the most highly upregulated NR in AAA tissues. ...R …
However, the role of NRs in AAA development remains largely unknown. METHODS: We analyzed the expression profile of the NR superfamil …
Ganglioside GM3 Protects Against Abdominal Aortic Aneurysm by Suppressing Ferroptosis.
Zhang F, Li K, Zhang W, Zhao Z, Chang F, Du J, Zhang X, Bao K, Zhang C, Shi L, Liu Z, Dai X, Chen C, Wang DW, Xian Z, Jiang H, Ai D. Zhang F, et al. Circulation. 2024 Mar 12;149(11):843-859. doi: 10.1161/CIRCULATIONAHA.123.066110. Epub 2023 Nov 29. Circulation. 2024. PMID: 38018467
BACKGROUND: Abdominal aortic aneurysm (AAA) is a potentially life-threatening vascular condition, but approved medical therapies to prevent AAA progression and rupture are currently lacking. ...CONCLUSIONS: Together, these results suggest that GM3 dysregulation prom …
BACKGROUND: Abdominal aortic aneurysm (AAA) is a potentially life-threatening vascular condition, but approved medical therapies to p …
Single-Cell Sequencing Analysis and Multiple Machine Learning Methods Identified G0S2 and HPSE as Novel Biomarkers for Abdominal Aortic Aneurysm.
Xiong T, Lv XS, Wu GJ, Guo YX, Liu C, Hou FX, Wang JK, Fu YF, Liu FQ. Xiong T, et al. Front Immunol. 2022 Jun 13;13:907309. doi: 10.3389/fimmu.2022.907309. eCollection 2022. Front Immunol. 2022. PMID: 35769488 Free PMC article.
Additionally, we used the multiple machine learning methods to identify biomarkers that differentiated large AAA from small AAA. Biomarkers were validated using GEO datasets. ...Immune cell infiltration analysis revealed that the AAA process may be mediated b …
Additionally, we used the multiple machine learning methods to identify biomarkers that differentiated large AAA from small AAA …
Mesenchymal stem cell-derived extracellular vesicles protect against abdominal aortic aneurysm formation by inhibiting NET-induced ferroptosis.
Chen L, Liu Y, Wang Z, Zhang L, Xu Y, Li Y, Zhang L, Wang G, Yang S, Xue G. Chen L, et al. Exp Mol Med. 2023 May;55(5):939-951. doi: 10.1038/s12276-023-00986-2. Epub 2023 May 1. Exp Mol Med. 2023. PMID: 37121969 Free PMC article.
The PI3K agonist 740 Y-P, the ferroptosis inhibitor ferrostatin-1, and Padi4 deficiency significantly prevented AAA formation. MSC-EVs attenuated AAA formation by reducing NET release in an angiotensin II-induced AAA mouse model. ...Our study indicates an imp …
The PI3K agonist 740 Y-P, the ferroptosis inhibitor ferrostatin-1, and Padi4 deficiency significantly prevented AAA formation. MSC-EV …
Erythropoietin promotes abdominal aortic aneurysms in mice through angiogenesis and inflammatory infiltration.
Zhang M, Sui W, Cheng C, Xue F, Tian Z, Cheng J, Zhang J, Zhang T, Zhang J, Wang W, Xiong W, Hao P, Ma J, Xu X, Wang S, Sun S, Zhang M, Zhang Y, Zhang C. Zhang M, et al. Sci Transl Med. 2021 Jul 21;13(603):eaaz4959. doi: 10.1126/scitranslmed.aaz4959. Sci Transl Med. 2021. PMID: 34290056
In humans, serum EPO concentrations were higher in patients with AAA than in healthy individuals and correlated with the size of the AAA, suggesting a potential link between EPO and the severity of AAA in humans. ...The association between EPO and AAA …
In humans, serum EPO concentrations were higher in patients with AAA than in healthy individuals and correlated with the size of the …
ADAR1 Non-Editing Function in Macrophage Activation and Abdominal Aortic Aneurysm.
Cai D, Sun C, Murashita T, Que X, Chen SY. Cai D, et al. Circ Res. 2023 Feb 17;132(4):e78-e93. doi: 10.1161/CIRCRESAHA.122.321722. Epub 2023 Jan 23. Circ Res. 2023. PMID: 36688311 Free PMC article.
BACKGROUND: Macrophage activation plays a critical role in abdominal aortic aneurysm (AAA) development. However, molecular mechanisms controlling macrophage activation and vascular inflammation in AAA remain largely unknown. ...RESULTS: Allograft transplantation of …
BACKGROUND: Macrophage activation plays a critical role in abdominal aortic aneurysm (AAA) development. However, molecular mechanisms …
Identification of crucial genes in abdominal aortic aneurysm by WGCNA.
Chen S, Yang D, Lei C, Li Y, Sun X, Chen M, Wu X, Zheng Y. Chen S, et al. PeerJ. 2019 Oct 8;7:e7873. doi: 10.7717/peerj.7873. eCollection 2019. PeerJ. 2019. PMID: 31608184 Free PMC article.
Thus, elucidating the molecular mechanism of AAA pathogenesis and exploring the potential molecular target of medical therapies for AAA is of vital importance. ...Further studies are needed to elucidate the detailed biological function of these genes in the pathogen …
Thus, elucidating the molecular mechanism of AAA pathogenesis and exploring the potential molecular target of medical therapies for …
Mitochondrial AAA+ proteases.
Matsushima Y. Matsushima Y. Enzymes. 2023;54:205-220. doi: 10.1016/bs.enz.2023.09.002. Epub 2023 Oct 13. Enzymes. 2023. PMID: 37945172
The wide range of mitochondrial functions is carried out by a diverse array of proteins comprising approximately 1500 proteins or polypeptides. Degradation of these proteins is mainly performed by four AAA+ proteases localized in mitochondria. These AAA+ proteases p …
The wide range of mitochondrial functions is carried out by a diverse array of proteins comprising approximately 1500 proteins or polypeptid …
6,065 results