Phosphatidylcholine (18:0/20:4), a potential biomarker to predict ethionamide-induced hepatic steatosis in rats.
Muta K, Saito K, Kemmochi Y, Masuyama T, Kobayashi A, Saito Y, Sugai S.
Muta K, et al.
J Appl Toxicol. 2022 Sep;42(9):1533-1547. doi: 10.1002/jat.4324. Epub 2022 Mar 29.
J Appl Toxicol. 2022.
PMID: 35315511
Free PMC article.
Ethionamide (ETH), a second-line drug for multidrug-resistant tuberculosis, is known to cause hepatic steatosis in rats and humans. To investigate predictive biomarkers for ETH-induced steatosis, we performed lipidomics analysis using plasma and liver samples …
Ethionamide (ETH), a second-line drug for multidrug-resistant tuberculosis, is known to cause hepatic steatosis in rats and humans. T …