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    Results: 1 to 20 of 86

    1.

    Integrated decision-tree testing strategies for skin corrosion and irritation with respect to the requirements of the EU REACH legislation.

    Grindon C, Combes R, Cronin MT, Roberts DW, Garrod JF.

    Altern Lab Anim. 2008 Oct;36 Suppl 1:65-74.PMID: 19025332 [PubMed - indexed for MEDLINE]Related articles

    2.

    Quantitative structure-property relationships modeling of skin irritation.

    Golla S, Madihally S, Robinson RL Jr, Gasem KA.

    Toxicol In Vitro. 2009 Feb;23(1):176-84. Epub 2008 Nov 5.PMID: 19027061 [PubMed - indexed for MEDLINE]Related articles

    3.

    Assessment of skin and eye irritation of 14 products under the stepwise approach of the OECD.

    Mancebo A, Hernández O, González Y, Aldana L, Carballo O.

    Cutan Ocul Toxicol. 2008;27(3):173-85.PMID: 18988087 [PubMed - indexed for MEDLINE]Related articles

    4.

    A feasibility study developing an integrated testing strategy assessing skin irritation potential of chemicals.

    Hoffmann S, Saliner AG, Patlewicz G, Eskes C, Zuang V, Worth AP.

    Toxicol Lett. 2008 Jul 30;180(1):9-20. Epub 2008 May 21.PMID: 18585875 [PubMed - indexed for MEDLINE]Related articles

    5.

    The use of reconstructed human epidermis for skin absorption testing: Results of the validation study.

    Schäfer-Korting M, Bock U, Diembeck W, Düsing HJ, Gamer A, Haltner-Ukomadu E, Hoffmann C, Kaca M, Kamp H, Kersen S, Kietzmann M, Korting HC, Krächter HU, Lehr CM, Liebsch M, Mehling A, Müller-Goymann C, Netzlaff F, Niedorf F, Rübbelke MK, Schäfer U, Schmidt E, Schreiber S, Spielmann H, Vuia A, Weimer M.

    Altern Lab Anim. 2008 May;36(2):161-87.PMID: 18522484 [PubMed - indexed for MEDLINE]Related articles

    6.

    Leiden reconstructed human epidermal model as a tool for the evaluation of the skin corrosion and irritation potential according to the ECVAM guidelines.

    El Ghalbzouri A, Siamari R, Willemze R, Ponec M.

    Toxicol In Vitro. 2008 Aug;22(5):1311-20. Epub 2008 Apr 7.PMID: 18474418 [PubMed - indexed for MEDLINE]Related articles

    7.

    [Current status of safety evaluation and alternative to animal testings in Japan]

    Kojima H.

    Yakugaku Zasshi. 2008 May;128(5):747-52. Review. Japanese. PMID: 18451623 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Successful validation of in vitro methods in toxicology by ZEBET, the National Centre for Alternatives in Germany at the BfR (Federal Institute for Risk Assessment).

    Spielmann H, Grune B, Liebsch M, Seiler A, Vogel R.

    Exp Toxicol Pathol. 2008 Jun;60(2-3):225-33. Epub 2008 Apr 28.PMID: 18440212 [PubMed - indexed for MEDLINE]Related articles

    9.

    Successful prevalidation of the slug mucosal irritation test to assess the eye irritation potency of chemicals.

    Adriaens E, Bytheway H, De Wever B, Eschrich D, Guest R, Hansen E, Vanparys P, Schoeters G, Warren N, Weltens R, Whittingham A, Remon JP.

    Toxicol In Vitro. 2008 Aug;22(5):1285-96. Epub 2008 Mar 4.PMID: 18406103 [PubMed - indexed for MEDLINE]Related articles

    10.

    An evaluation of the predictive ability of the QSAR software packages, DEREK, HAZARDEXPERT and TOPKAT, to describe chemically-induced skin irritation.

    Mombelli E.

    Altern Lab Anim. 2008 Feb;36(1):15-24.PMID: 18333711 [PubMed - indexed for MEDLINE]Related articles

    11.

    The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test--human cell line activation test (h-CLAT).

    Sakaguchi H, Ashikaga T, Miyazawa M, Kosaka N, Ito Y, Yoneyama K, Sono S, Itagaki H, Toyoda H, Suzuki H.

    Cell Biol Toxicol. 2009 Apr;25(2):109-26. Epub 2008 Jan 19.PMID: 18204907 [PubMed - indexed for MEDLINE]Related articles

    12.

    Integrated decision-tree testing strategies for skin corrosion and irritation with respect to the requirements of the EU REACH legislation.

    Grindon C, Combes R, Cronin MT, Roberts DW, Garrod JF.

    Altern Lab Anim. 2007 Dec;35(6):673-82.PMID: 18186672 [PubMed - indexed for MEDLINE]Related articles

    13.

    The ECVAM international validation study on in vitro tests for acute skin irritation: report on the validity of the EPISKIN and EpiDerm assays and on the Skin Integrity Function Test.

    Spielmann H, Hoffmann S, Liebsch M, Botham P, Fentem JH, Eskes C, Roguet R, Cotovio J, Cole T, Worth A, Heylings J, Jones P, Robles C, Kandárová H, Gamer A, Remmele M, Curren R, Raabe H, Cockshott A, Gerner I, Zuang V.

    Altern Lab Anim. 2007 Dec;35(6):559-601.PMID: 18186667 [PubMed - indexed for MEDLINE]Related articles

    14.

    [Construction of three-dimensional human skin model involving dendritic cells and its application to skin sensitization test]

    Uchino T, Takezawa T, Ikarashi Y, Tokunaga H.

    Yakugaku Zasshi. 2008 Jan;128(1):45-50. Review. Japanese. PMID: 18176055 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Phototoxicity and acute toxicity studies conducted by the FRAME Alternatives Laboratory: a brief review.

    Clothier RH.

    Altern Lab Anim. 2007 Oct;35(5):515-9. Review.PMID: 18001173 [PubMed - indexed for MEDLINE]Related articles

    16.

    An evaluation of the effects of photoactivation of bithionol, amiodarone and chlorpromazine on human keratinocytes in vitro.

    Reid L, Khammo N, Clothier RH.

    Altern Lab Anim. 2007 Oct;35(5):471-85.PMID: 18001169 [PubMed - indexed for MEDLINE]Related articles

    17.

    The usefulness of toxicogenomics for predicting acute skin irritation on in vitro reconstructed human epidermis.

    Borlon C, Godard P, Eskes C, Hartung T, Zuang V, Toussaint O.

    Toxicology. 2007 Nov 30;241(3):157-66. Epub 2007 Sep 4.PMID: 17928126 [PubMed - indexed for MEDLINE]Related articles

    18.

    Phototoxicity assessment of drugs and cosmetic products using E. coli.

    Verma K, Agrawal N, Misra RB, Farooq M, Hans RK.

    Toxicol In Vitro. 2008 Feb;22(1):249-53. Epub 2007 Aug 29.PMID: 17919881 [PubMed - indexed for MEDLINE]Related articles

    19.

    TIMES-SS--a mechanistic evaluation of an external validation study using reaction chemistry principles.

    Roberts DW, Patlewicz G, Dimitrov SD, Low LK, Aptula AO, Kern PS, Dimitrova GD, Comber MI, Phillips RD, Niemelä J, Madsen C, Wedebye EB, Bailey PT, Mekenyan OG.

    Chem Res Toxicol. 2007 Sep;20(9):1321-30. Epub 2007 Aug 23.PMID: 17713962 [PubMed - indexed for MEDLINE]Related articles

    20.

    Chemical reactivity indices and mechanism-based read-across for non-animal based assessment of skin sensitisation potential.

    Roberts DW, Aptula AO, Patlewicz G, Pease C.

    J Appl Toxicol. 2008 May;28(4):443-54. Review.PMID: 17703503 [PubMed - indexed for MEDLINE]Related articles

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