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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 5
1947 9
1948 3
1949 7
1950 7
1951 9
1952 10
1953 10
1954 9
1955 10
1956 4
1957 9
1958 6
1959 7
1960 4
1961 8
1962 7
1963 12
1964 9
1965 5
1966 3
1967 1
1968 2
1969 1
1970 1
1971 2
1972 4
1973 16
1974 23
1975 48
1976 40
1977 53
1978 50
1979 57
1980 49
1981 79
1982 137
1983 97
1984 148
1985 216
1986 258
1987 301
1988 280
1989 376
1990 448
1991 494
1992 474
1993 555
1994 618
1995 647
1996 670
1997 616
1998 643
1999 620
2000 678
2001 682
2002 645
2003 617
2004 614
2005 620
2006 656
2007 617
2008 575
2009 561
2010 600
2011 624
2012 661
2013 585
2014 589
2015 606
2016 551
2017 537
2018 489
2019 466
2020 515
2021 428
2022 414
2023 360
2024 89

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20,451 results

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Page 1
Discovery of Podofilox as a Potent cGAMP-STING Signaling Enhancer with Antitumor Activity.
Han J, Hu S, Hu Y, Xu Y, Hou Y, Yang Y, Su H, Zhang Z, Liu P, Sun X, Zhang C. Han J, et al. Cancer Immunol Res. 2023 May 3;11(5):583-599. doi: 10.1158/2326-6066.CIR-22-0483. Cancer Immunol Res. 2023. PMID: 36921097
In this study, we used a cell-based phenotypic screen and identified podophyllotoxin (podofilox), a microtubule destabilizer, as a robust enhancer of the cGAMP-STING signaling pathway. ...Furthermore, podofilox changed the trafficking pattern of STING and del …
In this study, we used a cell-based phenotypic screen and identified podophyllotoxin (podofilox), a microtubule destabilizer, …
Podophyllotoxin.
Canel C, Moraes RM, Dayan FE, Ferreira D. Canel C, et al. Phytochemistry. 2000 May;54(2):115-20. doi: 10.1016/s0031-9422(00)00094-7. Phytochemistry. 2000. PMID: 10872202 Review.
P. hexandnum Royle), is a good source of the aryltetralin-type lignan, podophyllotoxin. The latter compound, as well as its congeners and derivatives exhibit pronounced biological activity mainly as strong antiviral agents and as antineoplastic drugs. The podophyllotoxi …
P. hexandnum Royle), is a good source of the aryltetralin-type lignan, podophyllotoxin. The latter compound, as well as its congeners …
Podophyllotoxin derivatives targeting tubulin: An update (2017-2022).
Xu Y, He Z, Chen L, Wang H. Xu Y, et al. Drug Discov Today. 2023 Aug;28(8):103640. doi: 10.1016/j.drudis.2023.103640. Epub 2023 May 24. Drug Discov Today. 2023. PMID: 37236524 Review.
Numerous tubulin-targeted podophyllotoxin congeners have been designed and synthesized to overcome the poor water solubility of podophyllotoxin and improve its pharmaceutical characteristics. Understanding the interaction of tubulin with its downstream signal transd …
Numerous tubulin-targeted podophyllotoxin congeners have been designed and synthesized to overcome the poor water solubility of po …
Novel Anticancer Drugs from Nature.
Epifano F. Epifano F. Curr Med Chem. 2015;22(30):3406. doi: 10.2174/092986732230151019101908. Curr Med Chem. 2015. PMID: 26502948 No abstract available.
Advances of podophyllotoxin and its derivatives: Patterns and mechanisms.
Shi RJ, Fan HY, Yu XH, Tang YL, Jiang J, Liang XH. Shi RJ, et al. Biochem Pharmacol. 2022 Jun;200:115039. doi: 10.1016/j.bcp.2022.115039. Epub 2022 Apr 15. Biochem Pharmacol. 2022. PMID: 35436465 Review.
Podophyllotoxin (PPT) has attracted researchers' attention because of its ability to treat various ailments. A series of podophyllotoxin derivatives (PPTs) have been synthesized as candidate drugs to improve the pharmacological characteristics of PPT. ...
Podophyllotoxin (PPT) has attracted researchers' attention because of its ability to treat various ailments. A series of podophyll …
Podophyllotoxin: History, Recent Advances and Future Prospects.
Shah Z, Gohar UF, Jamshed I, Mushtaq A, Mukhtar H, Zia-Ui-Haq M, Toma SI, Manea R, Moga M, Popovici B. Shah Z, et al. Biomolecules. 2021 Apr 19;11(4):603. doi: 10.3390/biom11040603. Biomolecules. 2021. PMID: 33921719 Free PMC article. Review.
Podophyllotoxin, along with its various derivatives and congeners are widely recognized as broad-spectrum pharmacologically active compounds. ...The discovery of renewable sources including microbial origin for podophyllotoxin is another possible approach. This revi …
Podophyllotoxin, along with its various derivatives and congeners are widely recognized as broad-spectrum pharmacologically active co …
Recent Advances in the Chemistry and Biology of Podophyllotoxins.
Yu X, Che Z, Xu H. Yu X, et al. Chemistry. 2017 Apr 3;23(19):4467-4526. doi: 10.1002/chem.201602472. Epub 2017 Jan 9. Chemistry. 2017. PMID: 27726183 Review.
This Review provides a survey of podophyllotoxin and its analogues isolated from plants. In particular, recent developments in the elegant total chemical synthesis, structural modifications, biosynthesis, and biotransformation of podophyllotoxin and its analogues ar …
This Review provides a survey of podophyllotoxin and its analogues isolated from plants. In particular, recent developments in the el …
Chemistry and Biology of Podophyllotoxins: An Update.
Hao M, Xu H. Hao M, et al. Chemistry. 2024 Jan 16;30(4):e202302595. doi: 10.1002/chem.202302595. Epub 2023 Nov 14. Chemistry. 2024. PMID: 37814110 Review.
Podophyllotoxin is an aryltetralin lignan lactone derived from different plants of Podophyllum. ...The demand for podophyllotoxin and its derivatives is rising as a result of their high efficacy. ...
Podophyllotoxin is an aryltetralin lignan lactone derived from different plants of Podophyllum. ...The demand for podophyllotoxin …
2beta-Hydroxy-4'-demethyldesoxy-podophyllotoxin.
Du Boulay D, Shaari K, Skelton BW, Waterman PG, White AH. Du Boulay D, et al. Acta Crystallogr C. 2000 Feb;56 ( Pt 2):199-200. doi: 10.1107/s010827019901358x. Acta Crystallogr C. 2000. PMID: 10777886 No abstract available.
20,451 results
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