U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    BUR6 negative cofactor 2 transcription regulator complex subunit BUR6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856904, updated on 13-Apr-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    BUR6
    Gene description
    negative cofactor 2 transcription regulator complex subunit BUR6
    Primary source
    SGD:S000000961
    Locus tag
    YER159C
    See related
    AllianceGenome:SGD:S000000961
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NCB1
    Summary
    Enables several functions, including core promoter sequence-specific DNA binding activity; transcription coactivator activity; and transcription corepressor activity. Contributes to TBP-class protein binding activity. Involved in RNA polymerase II preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription from RNA polymerase II promoter in response to heat stress. Part of negative cofactor 2 complex. Orthologous to human DRAP1 (DR1 associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (491530..491958, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene tRNA-Glu Neighboring gene uncharacterized protein Neighboring gene tRNA-Arg Neighboring gene gag-pol fusion protein Neighboring gene gag protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Saccharomyces cerevisiae BUR6 encodes a DRAP1/NC2alpha homolog that has both positive and negative roles in transcription in vivo. Prelich G. Mol Cell Biol, 1997 Apr. PMID 9121454, Free PMC Article
    2. The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo. Kim S, et al. Proc Natl Acad Sci U S A, 1997 Feb 4. PMID 9023340, Free PMC Article
    3. The dual control of TFIIB recruitment by NC2 is gene specific. Masson P, et al. Nucleic Acids Res, 2008 Feb. PMID 18048413, Free PMC Article
    4. Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP). Cang Y, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12237409, Free PMC Article
    5. Yeast NC2 associates with the RNA polymerase II preinitiation complex and selectively affects transcription in vivo. Geisberg JV, et al. Mol Cell Biol, 2001 Apr. PMID 11283253, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables core promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of negative cofactor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of negative cofactor 2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of negative cofactor 2 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    negative cofactor 2 transcription regulator complex subunit BUR6
    NP_011086.3
    • Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      491530..491958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179049.3 → NP_011086.3  TPA: negative cofactor 2 transcription regulator complex subunit BUR6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011086.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM66, P40096
      UniProtKB/TrEMBL
      A0A6A5PYP7, A6ZRB6, B3LRS2, B5VHT7, C7GQ37, C8Z7I3, G2WD46, N1P5E8
      Conserved Domains (1) summary
      COG5247
      Location:25 → 142
      BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40096.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools