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    IntS12 Integrator 12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43227, updated on 4-Apr-2024

    Summary

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    Official Symbol
    IntS12provided by FlyBase
    Official Full Name
    Integrator 12provided by FlyBase
    Primary source
    FLYBASE:FBgn0039459
    Locus tag
    Dmel_CG5491
    See related
    AllianceGenome:FB:FBgn0039459
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5491; Dmel\CG5491; Int12
    Summary
    Involved in snRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Is expressed in organism. Orthologous to human INTS12 (integrator complex subunit 12). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    97D3-97D3; 3-92 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26863376..26864559)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22689098..22690281)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene lysosomal enzyme receptor protein Neighboring gene long non-coding RNA:CR46073 Neighboring gene mir-1012 stem loop Neighboring gene ballchen Neighboring gene Histone H2A variant

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes. Elrod ND, et al. Mol Cell, 2019 Dec 5. PMID 31809743, Free PMC Article
    2. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. Chen J, et al. J Biol Chem, 2013 Feb 15. PMID 23288851, Free PMC Article
    3. Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination. Tatomer DC, et al. Cold Spring Harb Symp Quant Biol, 2019. PMID 32086332
    4. The Integrator complex desensitizes cellular response to TGF-β/BMP signaling. Liu S, et al. Cell Rep, 2023 Jan 31. PMID 36641752
    5. Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination. Huang KL, et al. Mol Cell, 2020 Oct 15. PMID 32966759, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex
      Title: Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    integrator 12
    Names
    CG5491-PA
    IntS12-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26863376..26864559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143250.3 → NP_651507.1  integrator 12 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651507.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VBB3
      Related
      FBpp0084433
      Conserved Domains (1) summary
      cd15501
      Location:130 → 182
      PHD_Int12; PHD finger found in integrator complex subunit 12 (Int12) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBB3.1 Q9VBB3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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