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    wnd wallenda [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40143, updated on 4-Apr-2024

    Summary

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    Official Symbol
    wndprovided by FlyBase
    Official Full Name
    wallendaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036896
    Locus tag
    Dmel_CG8789
    See related
    AllianceGenome:FB:FBgn0036896
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8789; DLK; DLK/ZPK; Dmel\CG8789; MAPKKK; Wallenda; Wnd; Wnd/DLK
    Summary
    Predicted to enable protein kinase activity. Involved in several processes, including collateral sprouting of injured axon; memory; and regulation of synapse organization. Located in axon and neuromuscular junction. Is expressed in several structures, including anterior ectoderm; central nervous system; dorsal vessel primordium; embryonic epidermis; and extended germ band embryo. Orthologous to human MAP3K12 (mitogen-activated protein kinase kinase kinase 12) and MAP3K13 (mitogen-activated protein kinase kinase kinase 13). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    76B9-76B9; 3-45 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19624406..19635783, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19617506..19628883, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene male sterile (3) 76Cc Neighboring gene anti-silencing factor 1 Neighboring gene Ring finger protein 146 Neighboring gene Ornithine aminotransferase precursor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct homeostatic modulations stabilize reduced postsynaptic receptivity in response to presynaptic DLK signaling. Goel P, et al. Nat Commun, 2018 May 10. PMID 29748610, Free PMC Article
    2. A conditioning lesion protects axons from degeneration via the Wallenda/DLK MAP kinase signaling cascade. Xiong X, et al. J Neurosci, 2012 Jan 11. PMID 22238096, Free PMC Article
    3. Drosophila model of anti-retroviral therapy induced peripheral neuropathy and nociceptive hypersensitivity. Bush KM, et al. Biol Open, 2021 Jan 27. PMID 33504470, Free PMC Article
    4. Analyzing chemotherapy-induced peripheral neuropathy in vivo using non-mammalian animal models. Cirrincione AM, et al. Exp Neurol, 2020 Jan. PMID 31669484, Free PMC Article
    5. Discordant Responses to MAPK Pathway Stimulation Include Axonal Growths in Adult Drosophila Photoreceptors. Mecklenburg KL, et al. Front Mol Neurosci, 2018. PMID 30564098, Free PMC Article

    See all (125) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of the Wallenda JNKKK as an Alk suppressor reveals increased competitiveness of Alk-expressing cells.
      Title: Identification of the Wallenda JNKKK as an Alk suppressor reveals increased competitiveness of Alk-expressing cells.
    2. Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome.
      Title: Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome.
    3. These studies at the Drosophila neuromuscular junction indicate that many synaptic defects in unc-104-null mutants are mediated independently of Unc-104's transport function, via the Wallenda (Wnd)/DLK MAP kinase axonal damage signaling pathway.
      Title: Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104.
    4. Here the authors identify the Dual Leucine-zipper Kinase (DLK, Wnd in Drosophila) as a critical target and effector of cAMP in injured axons.
      Title: An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK.
    5. Wallenda/DLK protein levels are temporally downregulated by Tramtrack69 to allow R7 growth cones to become stationary boutons
      Title: Wallenda/DLK protein levels are temporally downregulated by Tramtrack69 to allow R7 growth cones to become stationary boutons.
    6. our study in Drosophila has uncovered a novel physiological function for Wnd in modulating cell invasion
      Title: Rho1-Wnd signaling regulates loss-of-cell polarity-induced cell invasion in Drosophila.
    7. DLK is not essential for dendrite regeneration.
      Title: Dendrite injury triggers DLK-independent regeneration.
    8. The dual leucine zipper kinase (DLK) signaling pathway in Drosophila, which consists of Highwire and Wallenda and controls axonal growth, regeneration, and degeneration, is also involved in dendritic growth in vivo.
      Title: Bimodal control of dendritic and axonal growth by the dual leucine zipper kinase pathway.
    9. The results of this study indicated that Wnd regulates multiple independent pathways in Drosophila motoneurons and that JIP1 scaffolds a specific downstream cascade required for the organization of presynaptic microtubules during synaptic development.
      Title: Independent pathways downstream of the Wnd/DLK MAPKKK regulate synaptic structure, axonal transport, and injury signaling.
    10. Wnd regulates an adaptive response to injury that allows neurons to cope with axonal stress.
      Title: A conditioning lesion protects axons from degeneration via the Wallenda/DLK MAP kinase signaling cascade.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: c19629120-19628542 mobile_element_type = transposon:INE-1{}5213

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in collateral sprouting of injured axon IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in medium-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synaptic assembly at neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of terminal button organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sprouting of injured axon IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    wallenda
    Names
    CG8789-PA
    CG8789-PB
    CG8789-PC
    CG8789-PD
    dual leucine zipper kinase
    dual leucine zipper-bearing kinase
    wnd-PA
    wnd-PB
    wnd-PC
    wnd-PD
    NP_001189132.1
    NP_649137.3
    NP_788540.1
    NP_788541.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19624406..19635783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176363.3 → NP_788541.1  wallenda, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788541.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VW24
      Related
      FBpp0074733
      Conserved Domains (2) summary
      smart00221
      Location:161 → 400
      STYKc; Protein kinase; unclassified specificity
      cd14059
      Location:167 → 403
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

    2. NM_140880.3 → NP_649137.3  wallenda, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649137.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VW24
      Related
      FBpp0074731
      Conserved Domains (2) summary
      smart00221
      Location:161 → 400
      STYKc; Protein kinase; unclassified specificity
      cd14059
      Location:167 → 403
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

    3. NM_176362.2 → NP_788540.1  wallenda, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788540.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VW24
      Related
      FBpp0074732
      Conserved Domains (2) summary
      smart00221
      Location:161 → 400
      STYKc; Protein kinase; unclassified specificity
      cd14059
      Location:167 → 403
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

    4. NM_001202203.1 → NP_001189132.1  wallenda, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189132.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMF6
      Conserved Domains (2) summary
      smart00221
      Location:134 → 373
      STYKc; Protein kinase; unclassified specificity
      cd14059
      Location:140 → 376
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3DMF6 D3DMF6
    Q9VW24 Q9VW24

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