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    scny scrawny [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38648, updated on 11-Apr-2024

    Summary

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    Official Symbol
    scnyprovided by FlyBase
    Official Full Name
    scrawnyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260936
    Locus tag
    Dmel_CG5505
    See related
    AllianceGenome:FB:FBgn0260936
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2331; anon-WO0118547.247; CG5505; Dmel\CG5505; dUsp36; dUSP36; et; l(3)02331; mule; Q9VRP5; Scny; SP36/Scny; usp36; Usp36; USP36
    Summary
    Enables Lys63-specific deubiquitinase activity and thiol-dependent deubiquitinase. Involved in several processes, including negative regulation of immune response; protein deubiquitination; and regulation of cellular catabolic process. Located in nucleolus. Is expressed in several structures, including adult brain cell body rind; adult fat body; central body; germline stem cell; and salivary gland. Used to study congenital heart disease. Orthologous to several human genes including USP36 (ubiquitin specific peptidase 36). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See scny in Genome Data Viewer
    Location:
    64E7-64E7; 3-15 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5769002..5776271)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5762102..5769371)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45831 Neighboring gene Thioredoxin-like Neighboring gene Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase Neighboring gene viriato Neighboring gene Myt1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila deubiquitinating enzyme dUSP36 acts in the hemocytes for tolerance to Listeria monocytogenes infections. Taillebourg E, et al. J Innate Immun, 2014. PMID 24777180, Free PMC Article
    2. A Nucleolar Isoform of the Drosophila Ubiquitin Specific Protease dUSP36 Regulates MYC-Dependent Cell Growth. Thevenon D, et al. Front Cell Dev Biol, 2020. PMID 32637412, Free PMC Article
    3. Molecular Evolution of Drosophila Germline Stem Cell and Neural Stem Cell Regulating Genes. Choi JY, et al. Genome Biol Evol, 2015 Oct 27. PMID 26507797, Free PMC Article
    4. Drosophila stem cells share a common requirement for the histone H2B ubiquitin protease scrawny. Buszczak M, et al. Science, 2009 Jan 9. PMID 19039105, Free PMC Article
    5. Identification of Genes Mediating Drosophila Follicle Cell Progenitor Differentiation by Screening for Modifiers of GAL4::UAS Variegation. Lee MC, et al. G3 (Bethesda), 2017 Jan 5. PMID 27866148, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. specific inactivation in hemocytes renders susceptibility to L. monocytogenes infections
      Title: The Drosophila deubiquitinating enzyme dUSP36 acts in the hemocytes for tolerance to Listeria monocytogenes infections.
    2. USP36 controls selective autophagy activation in Drosophila and in human cells.
      Title: The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins.
    3. The study describes Drosophila ubiquitin protease USP36/Scny function in innate immunity. USP36 is notably required in the gut and prevents constitutive activation of NF-kappaB signal by hydrolysing K63 ubiquitin chains on the adaptator molecule IMD.
      Title: The Drosophila ubiquitin-specific protease dUSP36/Scny targets IMD to prevent constitutive immune signaling.
    4. study describes a Drosophila gene, scrawny (scny), encoding a ubiquitin-specific protease, which is required in germline, epithelial & intestinal stem cells; it deubiquitylates histone H2B and functions in gene silencing
      Title: Drosophila stem cells share a common requirement for the histone H2B ubiquitin protease scrawny.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K63-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    scrawny
    Names
    CG5505-PB
    CG5505-PC
    CG5505-PD
    CG5505-PG
    CG5505-PH
    CG5505-PI
    CG5505-PJ
    emperor's thumb
    lethal (3) 02331
    mule
    scny-PB
    scny-PC
    scny-PD
    scny-PG
    scny-PH
    scny-PI
    scny-PJ
    ubiquitin C-terminal hydrolase 36
    ubiquitin specific protease 36
    ubiquitin-specific protease 36
    NP_001246639.1
    NP_001246640.1
    NP_647986.3
    NP_729092.1
    NP_729093.2
    NP_729094.1
    NP_729095.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5769002..5776271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168132.3 → NP_729092.1  scrawny, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729092.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NE30, Q7YTX7, Q86NM9, Q8IQ57, Q8IQ58, Q8IQ59, Q8IQ60, Q960Q4, Q9VRP5
      Related
      FBpp0076806
      Conserved Domains (3) summary
      pfam05279
      Location:617 → 731
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      cd02661
      Location:171 → 477
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:172 → 477
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. NM_001259710.2 → NP_001246639.1  scrawny, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246639.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VRP5
      Conserved Domains (3) summary
      pfam05279
      Location:617 → 731
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      cd02661
      Location:171 → 477
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:172 → 477
      UCH; Ubiquitin carboxyl-terminal hydrolase

    3. NM_001259711.2 → NP_001246640.1  scrawny, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246640.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VRP5
      Conserved Domains (3) summary
      pfam05279
      Location:617 → 731
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      cd02661
      Location:171 → 477
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:172 → 477
      UCH; Ubiquitin carboxyl-terminal hydrolase

    4. NM_139729.3 → NP_647986.3  scrawny, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647986.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VRP5
      Conserved Domains (3) summary
      pfam05279
      Location:547 → 661
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      cd02661
      Location:101 → 407
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:102 → 407
      UCH; Ubiquitin carboxyl-terminal hydrolase

    5. NM_168135.2 → NP_729095.1  scrawny, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729095.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VRP5
      Related
      FBpp0076807
      Conserved Domains (3) summary
      pfam05279
      Location:547 → 661
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      cd02661
      Location:101 → 407
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:102 → 407
      UCH; Ubiquitin carboxyl-terminal hydrolase

    6. NM_168134.2 → NP_729094.1  scrawny, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729094.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VRP5
      Related
      FBpp0076809
      Conserved Domains (3) summary
      pfam05279
      Location:527 → 641
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      cd02661
      Location:81 → 387
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:82 → 387
      UCH; Ubiquitin carboxyl-terminal hydrolase

    7. NM_168133.2 → NP_729093.2  scrawny, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729093.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VRP5
      Conserved Domains (3) summary
      pfam05279
      Location:527 → 641
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      cd02661
      Location:81 → 387
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:82 → 387
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRP5.3 Q9VRP5

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