H4c16 H4 histone 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H4c16provided by MGI
Official Full Name: H4 histone 16provided by MGI
Primary source: MGI:MGI:2448443
See related: Ensembl:ENSMUSG00000096010 AllianceGenome:MGI:2448443
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H4c1; H4c2; H4c3; H4c4; H4c6; H4c8; H4c9; H4-16; H4c11; H4c12; H4c14; H4f16; Hist4h4; B130044J01Rik
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. [provided by RefSeq, Aug 2015]
Orthologs: human all
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Genomic context

Location:: 6 G1; 6 66.72 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (136780991..136781429, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (136803993..136804431, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studies indicate that abnormal axial chromatid condensation during meiosis results in the formation of elongated chromosomes exhibiting hyperacetylation of histone H4 at lysine 5 and lysine 16 at interstitial chromosome segments.
Title: Histone hyperacetylation during meiosis interferes with large-scale chromatin remodeling, axial chromatid condensation and sister chromatid separation in the mammalian oocyte.
This study showed an increase in the level of global DNA methylation starting in oocytes with diameters around 60 microm, increases in histone h4, and decreases in AKAP95.
Title: DNA methylation, histone modifications and behaviour of AKAP95 during mouse oocyte growth and upon nuclear transfer of foreign chromatin into fully grown prophase oocytes.
Expression of histone H4 is increased at 16 h after induction when 3T3-L1 preadipocytes synchronously reenter S phase, which is correlated with the sequential phosphorylation and activation of C/EBPbeta
Title: Transcriptional activation of histone H4 by C/EBPβ during the mitotic clonal expansion of 3T3-L1 adipocyte differentiation.
Data demonstrate the role of histone H4 arginine methylation in cortical development.
Title: Dynamic distribution of histone H4 arginine 3 methylation marks in the developing murine cortex.
the SET8 and PCNA interaction couples H4-K20 methylation with DNA replication
Title: Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication.
acetylation and methylation status of histones H3 and H4 in a mouse model of Rett syndrome where the MeCP2 locus is genetically disrupted.
Title: Histone H3 and H4 modification profiles in a Rett syndrome mouse model.
cAMP treatment results in a decrease in acetylation of Histh4.
Title: Chromatin-dependent regulation of the MMTV promoter by cAMP signaling is mediated through distinct pathways.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hist4h4 (e-PCR), detects polymorphism
- UniSTS:545860

NoName (e-PCR)
- UniSTS:489545

px-42d4 (e-PCR)
- UniSTS:257776

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of chromatin	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CENP-A containing nucleosome	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone H4

Names: histone 4, H4; histone cluster 4, H4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.