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    CG31674 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318878, updated on 11-Apr-2024

    Summary

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    Official Symbol
    CG31674provided by FlyBase
    Primary source
    FLYBASE:FBgn0051674
    Locus tag
    Dmel_CG31674
    See related
    AllianceGenome:FB:FBgn0051674
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9332; Dmel\CG31674
    Summary
    Predicted to enable glycerate dehydrogenase activity; glyoxylate reductase (NADP+) activity; and hydroxypyruvate reductase activity. Predicted to be active in cytosol. Is expressed in adult head. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    38F1-38F1; 2-54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20831262..20832859)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20831262..20832859)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Outer segment 5 Neighboring gene Serpin 38F Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44307

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transporters and tubule crystals in the insect Malpighian tubule. Reynolds CJ, et al. Curr Opin Insect Sci, 2021 Oct. PMID 34044181, Free PMC Article
    2. Proteomic Analysis of Red Ginseng on Prolonging the Life Span of Male Drosophila melanogaster. Hou W, et al. Front Pharmacol, 2021. PMID 34177563, Free PMC Article
    3. A genome-wide RNAi screen reveals multiple regulators of caspase activation. Yi CH, et al. J Cell Biol, 2007 Nov 19. PMID 17998402, Free PMC Article
    4. Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC). Borrás T, et al. Genetics, 2003 Feb. PMID 12618402, Free PMC Article
    5. Gene expression in a Drosophila model of mitochondrial disease. Fernández-Ayala DJ, et al. PLoS One, 2010 Jan 6. PMID 20066047, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glyoxylate reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxypyruvate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31674-PA
    CG31674-PB
    NP_001286111.1
    NP_610063.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20831262..20832859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136219.6 → NP_610063.4  uncharacterized protein Dmel_CG31674, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610063.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWS3, Q8INU6
      Related
      FBpp0080952
      Conserved Domains (2) summary
      COG1052
      Location:9 → 321
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:8 → 319
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

    2. NM_001299182.1 → NP_001286111.1  uncharacterized protein Dmel_CG31674, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286111.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWS3, Q8INU6
      Conserved Domains (2) summary
      COG1052
      Location:9 → 321
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:8 → 319
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AWS3 Q6AWS3
    Q8INU6 Q8INU6

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