elt-1 GATA-type domain-containing protein;Transcription factor elt-1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: elt-1
Gene description: GATA-type domain-containing protein;Transcription factor elt-1
Primary source: WormBase:WBGene00001249
Locus tag: CELE_W09C2.1
See related: AllianceGenome:WB:WBGene00001249
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including epidermal cell fate specification; regulation of transcription by RNA polymerase II; and spermatid development. Located in nucleus. Is expressed in several structures, including V1L.a; anal region; hypodermal cell; neurons; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; X-linked recessive disease (multiple); adenocarcinoma (multiple); congenital heart disease (multiple); and hematologic cancer (multiple). Orthologous to several human genes including GATA1 (GATA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (9614995..9620280)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this work suggest that the contribution of ELT-1 to the control of let-7 family microRNA expression is likely through direct transcription regulation.
Title: The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs.
Data suggest that ELT-1 has dual roles in the stem-like seam cells, acting both to promote proliferation and prevent differentiation.
Title: The Caenorhabditis elegans GATA factor ELT-1 works through the cell proliferation regulator BRO-1 and the Fusogen EFF-1 to maintain the seam stem-like fate.
analysis of regulation of sperm gene expression by the GATA factor ELT-1
Title: Regulation of sperm gene expression by the GATA factor ELT-1.
elt-1 is a key regulator of neuronal function in larvae and adult worms.
Title: The Caenorhabditis elegans GATA factor elt-1 is essential for differentiation and maintenance of hypodermal seam cells and for normal locomotion.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W09C2.1 (e-PCR)
- UniSTS:315198

STS4-166 (e-PCR)
- UniSTS:242155

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GATA-type domain-containing protein;Transcription factor elt-1

NP_001033435.1

Confirmed by transcript evidence

NP_001033436.1

Confirmed by transcript evidence

NP_001255402.1

Confirmed by transcript evidence

NP_001255404.1

Confirmed by transcript evidence

NP_001368126.1

Confirmed by transcript evidence

NP_001380174.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

9614995..9620280

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001038346.6 → NP_001033435.1 GATA-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001033435.1

Status: REVIEWED

UniProtKB/TrEMBL

Q3S1J8

Conserved Domains (2) summary

smart00401
Location:285 → 332

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:343 → 394

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_001268473.4 → NP_001255402.1 GATA-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255402.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G2S7

Conserved Domains (2) summary

smart00401
Location:285 → 332

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:342 → 393

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_001380414.1 → NP_001368126.1 GATA-type domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H9G2S6

Conserved Domains (1) summary

cd00202
Location:342 → 393

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_001392371.1 → NP_001380174.1 GATA-type domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A061ACV8

Conserved Domains (1) summary

cd00202
Location:270 → 321

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_001038347.3 → NP_001033436.1 Transcription factor elt-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001033436.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P28515, Q3S1J7

Conserved Domains (2) summary

smart00401
Location:213 → 260

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:271 → 322

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_001268475.3 → NP_001255404.1 Transcription factor elt-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255404.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G2S5