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    eor-1 C2H2-type domain-containing protein;Zinc finger protein [ Caenorhabditis elegans ]

    Gene ID: 177249, updated on 23-Nov-2023

    Summary

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    Gene symbol
    eor-1
    Gene description
    C2H2-type domain-containing protein;Zinc finger protein
    Primary source
    WormBase:WBGene00001324
    Locus tag
    CELE_R11E3.6
    See related
    AllianceGenome:WB:WBGene00001324
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in nucleus. Is expressed in several structures, including epithelial system; gonad; nervous system; and pharynx. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 2. Orthologous to human MYNN (myoneurin); ZBTB24 (zinc finger and BTB domain containing 24); and ZNF358 (zinc finger protein 358). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    15
    Sequence:
    Chromosome: IV; NC_003282.8 (4793194..4799178, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Tyrosine-protein kinase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Dipeptidyl Peptidase Four (IV) family Neighboring gene acylaminoacyl-peptidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chromatin accessibility dynamics reveal novel functional enhancers in C. elegans. Daugherty AC, et al. Genome Res, 2017 Dec. PMID 29141961, Free PMC Article
    2. Regulation of chromatin states and gene expression during HSN neuronal maturation is mediated by EOR-1/PLZF, MAU-2/cohesin loader, and SWI/SNF complex. Shinkai Y, et al. Sci Rep, 2018 May 21. PMID 29786685, Free PMC Article
    3. SKN-1-independent transcriptional activation of glutathione S-transferase 4 (GST-4) by EGF signaling. Detienne G, et al. Worm, 2016. PMID 28090393, Free PMC Article
    4. Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans. Kumar N, et al. Oncotarget, 2015 Dec 8. PMID 26539642, Free PMC Article
    5. eor-1 and eor-2 are required for cell-specific apoptotic death in C. elegans. Hoeppner DJ, et al. Dev Biol, 2004 Oct 1. PMID 15355793

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the interaction between EOR-1 and EOR-2
      Title: EOR-2 is an obligate binding partner of the BTB-zinc finger protein EOR-1 in Caenorhabditis elegans.
    2. eor-1 and eor-2 function together throughout the nervous system to promote terminal differentiation of neurons and function specifically in male hermaphrodite-specific neurons to promote apoptotic death.
      Title: eor-1 and eor-2 are required for cell-specific apoptotic death in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C2H2-type domain-containing protein;Zinc finger protein
    NP_001367921.1
    • Confirmed by transcript evidence
    NP_001368235.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4793194..4799178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380207.3 → NP_001367921.1  Zinc finger protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDU4
      Conserved Domains (6) summary
      PHA03098
      Location:34 → 229
      PHA03098; kelch-like protein; Provisional
      sd00017
      Location:601 → 618
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18186
      Location:41 → 118
      BTB_POZ_ZBTB_KLHL-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins
      pfam13465
      Location:638 → 663
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:652 → 676
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam15909
      Location:481 → 527
      zf-C2H2_8; C2H2-type zinc ribbon

    2. NM_001380208.1 → NP_001368235.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PEC2
      Conserved Domains (4) summary
      sd00017
      Location:8 → 28
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:8 → 28
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:20 → 45
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:34 → 58
      zf-H2C2_5; C2H2-type zinc-finger domain
    Nucleotide Protein
    Heading Accession and Version

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