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    aak-1 5'-AMP-activated protein kinase catalytic subunit alpha-1 [ Caenorhabditis elegans ]

    Gene ID: 176230, updated on 23-Nov-2023

    Summary

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    Gene symbol
    aak-1
    Gene description
    5'-AMP-activated protein kinase catalytic subunit alpha-1
    Primary source
    WormBase:WBGene00019801
    Locus tag
    CELE_PAR2.3
    See related
    AllianceGenome:WB:WBGene00019801
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in negative regulation of cell population proliferation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; colon cancer; lung non-small cell carcinoma; and type 2 diabetes mellitus. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1) and PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (8756990..8761090, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Dwarfin sma-2;MH2 domain-containing protein Neighboring gene Mitochondrial import receptor subunit tomm-70 Neighboring gene ncRNA Neighboring gene Chondroitin sulfate synthase mig-22 Neighboring gene Single-stranded DNA-binding protein, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans as a Useful Model for Studying Aging Mutations. Zhang S, et al. Front Endocrinol (Lausanne), 2020. PMID 33123086, Free PMC Article
    2. Fat-lowering effects of isorhamnetin are via NHR-49-dependent pathway in Caenorhabditis elegans. Farias-Pereira R, et al. Curr Res Food Sci, 2020 Jun. PMID 32914113, Free PMC Article
    3. Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy. Zaninello M, et al. Nat Commun, 2020 Aug 12. PMID 32788597, Free PMC Article
    4. Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span. Zemel MB. J Med Food, 2020 Nov. PMID 32758058
    5. Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans. Gómez-Escribano AP, et al. Pharmacol Res, 2020 Nov. PMID 32739430, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    5'-AMP-activated protein kinase catalytic subunit alpha-1
    NP_001380007.1
    • Confirmed by transcript evidence
    NP_741254.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8756990..8761090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392162.1 → NP_001380007.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      cd14336
      Location:121 → 185
      UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits
      cl17070
      Location:219 → 308
      AMPKA_C_like; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains
      cl21453
      Location:1 → 105
      PKc_like; Protein Kinases, catalytic domain

    2. NM_171216.6 → NP_741254.3  5'-AMP-activated protein kinase catalytic subunit alpha-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741254.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P45894, Q3HKC8, Q3HKC9, Q5VKL2
      Conserved Domains (4) summary
      cd12122
      Location:390 → 479
      AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
      smart00220
      Location:24 → 276
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14336
      Location:292 → 356
      UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits
      cl21453
      Location:21 → 276
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45894.2

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