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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1817 1
1823 1
1827 1
1828 1
1830 1
1832 1
1840 1
1841 2
1843 2
1844 1
1846 1
1849 2
1850 2
1855 3
1856 1
1857 1
1858 3
1860 1
1862 2
1863 1
1865 1
1868 3
1871 1
1872 1
1873 3
1874 2
1875 1
1877 1
1880 56
1882 2
1883 4
1886 1
1887 5
1888 1
1889 2
1890 163
1891 170
1892 177
1893 97
1894 127
1895 341
1896 417
1897 381
1898 289
1899 247
1900 263
1901 254
1902 198
1903 82
1905 1
1908 1
1911 1
1912 2
1913 1
1914 2
1915 3
1916 1
1918 1
1923 4
1924 2
1925 59
1926 106
1927 138
1928 87
1929 166
1930 124
1931 97
1932 77
1933 131
1934 79
1935 74
1936 86
1937 84
1938 80
1939 58
1940 46
1941 26
1942 48
1943 38
1944 50
1945 736
1946 2591
1947 3004
1948 3179
1949 3203
1950 5479
1951 6173
1952 6428
1953 6627
1954 6500
1955 7096
1956 6382
1957 6941
1958 6367
1959 6355
1960 6369
1961 6382
1962 5853
1963 6687
1964 7677
1965 7775
1966 7534
1967 8623
1968 9015
1969 9699
1970 8594
1971 8216
1972 8610
1973 8356
1974 8233
1975 8250
1976 7760
1977 8347
1978 8568
1979 8624
1980 8240
1981 7834
1982 8188
1983 8198
1984 8513
1985 8649
1986 9012
1987 9333
1988 9118
1989 10180
1990 9495
1991 9017
1992 9097
1993 9056
1994 9273
1995 9370
1996 9689
1997 9947
1998 9929
1999 9565
2000 10712
2001 10113
2002 10080
2003 10481
2004 10572
2005 11230
2006 11531
2007 12262
2008 13095
2009 13006
2010 13772
2011 14513
2012 15518
2013 13319
2014 13818
2015 14086
2016 14556
2017 14129
2018 14006
2019 14831
2020 17396
2021 19467
2022 18821
2023 17929
2024 9297

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708,868 results

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Page 1
Atherosclerosis: Recent developments.
Björkegren JLM, Lusis AJ. Björkegren JLM, et al. Cell. 2022 May 12;185(10):1630-1645. doi: 10.1016/j.cell.2022.04.004. Epub 2022 May 2. Cell. 2022. PMID: 35504280 Free PMC article. Review.
We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the …
We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of in …
Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease.
Marnell CS, Bick A, Natarajan P. Marnell CS, et al. J Mol Cell Cardiol. 2021 Dec;161:98-105. doi: 10.1016/j.yjmcc.2021.07.004. Epub 2021 Jul 21. J Mol Cell Cardiol. 2021. PMID: 34298011 Free PMC article. Review.
Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals without evidence of hematologic malignancy, dysplasia, or cytopenia. ...
Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally expanded hematopoietic stem cell caused b …
Clonal hematopoiesis and nonhematologic disorders.
Jaiswal S. Jaiswal S. Blood. 2020 Oct 1;136(14):1606-1614. doi: 10.1182/blood.2019000989. Blood. 2020. PMID: 32736379 Free PMC article. Review.
Clonal expansions of mutated hematopoietic cells, termed clonal hematopoiesis, are common in aging humans. ...Emerging data also associate clonal hematopoiesis with other nonhematologic diseases. Here, we will review recent studies linking cl …
Clonal expansions of mutated hematopoietic cells, termed clonal hematopoiesis, are common in aging humans. ...Emerging …
Causes and consequences of clonal hematopoiesis.
Weeks LD, Ebert BL. Weeks LD, et al. Blood. 2023 Dec 28;142(26):2235-2246. doi: 10.1182/blood.2023022222. Blood. 2023. PMID: 37931207 Review.
Clonal hematopoiesis (CH) is described as the outsized contribution of expanded clones of hematopoietic stem and progenitor cells (HSPCs) to blood cell production. ...Moreover, CH is associated with nonmalignant disorders and increased overall mortality. The somatic …
Clonal hematopoiesis (CH) is described as the outsized contribution of expanded clones of hematopoietic stem and progenitor ce …
NPM1-mutated acute myeloid leukemia: from bench to bedside.
Falini B, Brunetti L, Sportoletti P, Martelli MP. Falini B, et al. Blood. 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. Blood. 2020. PMID: 32609823 Free article. Review.
We also discuss the importance of eradicating NPM1-mutated clones to achieve AML cure and the impact of preleukemic clonal hematopoiesis persistence in predisposing to second AML. The contribution of HOX genes' expression to the development of NPM1-mutated AML is al …
We also discuss the importance of eradicating NPM1-mutated clones to achieve AML cure and the impact of preleukemic clonal hematop …
Clonal hematopoiesis: Mutation-specific adaptation to environmental change.
Florez MA, Tran BT, Wathan TK, DeGregori J, Pietras EM, King KY. Florez MA, et al. Cell Stem Cell. 2022 Jun 2;29(6):882-904. doi: 10.1016/j.stem.2022.05.006. Cell Stem Cell. 2022. PMID: 35659875 Free PMC article. Review.
Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion of genetically variant hematopoietic cells that increases exponentially with age and is associated with increased risks of cancers, cardiovascular disease, and other maladies. .. …
Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion of genetically variant hematopoietic c …
Distinction of lymphoid and myeloid clonal hematopoiesis.
Niroula A, Sekar A, Murakami MA, Trinder M, Agrawal M, Wong WJ, Bick AG, Uddin MM, Gibson CJ, Griffin GK, Honigberg MC, Zekavat SM, Paruchuri K, Natarajan P, Ebert BL. Niroula A, et al. Nat Med. 2021 Nov;27(11):1921-1927. doi: 10.1038/s41591-021-01521-4. Epub 2021 Oct 18. Nat Med. 2021. PMID: 34663986 Free PMC article.
Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal expansion of blood cells. ...
Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal expansion of blood cells. ...
Clonal haematopoiesis and dysregulation of the immune system.
Belizaire R, Wong WJ, Robinette ML, Ebert BL. Belizaire R, et al. Nat Rev Immunol. 2023 Sep;23(9):595-610. doi: 10.1038/s41577-023-00843-3. Epub 2023 Mar 20. Nat Rev Immunol. 2023. PMID: 36941354 Free PMC article. Review.
Recent analyses of human genetic data have revealed that somatic mutations and mosaic chromosomal alterations in blood cells - a condition known as clonal haematopoiesis (CH) - are associated with ageing and pathological immune dysfunction. ...
Recent analyses of human genetic data have revealed that somatic mutations and mosaic chromosomal alterations in blood cells - a condition k …
Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis.
Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Słabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL. Kim PG, et al. J Exp Med. 2021 Dec 6;218(12):e20211872. doi: 10.1084/jem.20211872. Epub 2021 Oct 26. J Exp Med. 2021. PMID: 34698806 Free PMC article.
Recurrent somatic mutations that lead to an expanded population of mutant blood cells is termed clonal hematopoiesis of indeterminate potential (CHIP). Analyzing exome sequencing data from the UK Biobank, we found CHIP to be associated with increased incident osteop …
Recurrent somatic mutations that lead to an expanded population of mutant blood cells is termed clonal hematopoiesis of indete …
Clonal Hematopoiesis, Inflammation, and Hematologic Malignancy.
Kanagal-Shamanna R, Beck DB, Calvo KR. Kanagal-Shamanna R, et al. Annu Rev Pathol. 2024 Jan 24;19:479-506. doi: 10.1146/annurev-pathmechdis-051222-122724. Epub 2023 Oct 13. Annu Rev Pathol. 2024. PMID: 37832948 Free article. Review.
Here, we review the somatic mutations that accumulate in the blood and their connection to disease states, with a particular focus on inflammatory diseases and myelodysplastic syndrome. We include a definition of clonal hematopoiesis (CH) and an overview of the orig …
Here, we review the somatic mutations that accumulate in the blood and their connection to disease states, with a particular focus on inflam …
708,868 results
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