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Page 1
Accelerating inhibitor discovery for deubiquitinating enzymes.
Nat Commun. 2023 Feb 8;14(1):686. doi: 10.1038/s41467-023-36246-0.
Nat Commun. 2023.
PMID: 36754960
Free PMC article.
Identification of deubiquitinase inhibitors via high-throughput screening using a fluorogenic ubiquitin-rhodamine assay.
Varca AC, Casalena D, Auld D, Buhrlage SJ.
Varca AC, et al.
STAR Protoc. 2021 Oct 19;2(4):100896. doi: 10.1016/j.xpro.2021.100896. eCollection 2021 Dec 17.
STAR Protoc. 2021.
PMID: 34723213
Free PMC article.
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Identification and validation of selective deubiquitinase inhibitors.
Varca AC, Casalena D, Chan WC, Hu B, Magin RS, Roberts RM, Liu X, Zhu H, Seo HS, Dhe-Paganon S, Marto JA, Auld D, Buhrlage SJ.
Varca AC, et al.
Cell Chem Biol. 2021 Dec 16;28(12):1758-1771.e13. doi: 10.1016/j.chembiol.2021.05.012. Epub 2021 Jun 14.
Cell Chem Biol. 2021.
PMID: 34129829
Free PMC article.
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Proteomics-Based Identification of DUB Substrates Using Selective Inhibitors.
Bushman JW, Donovan KA, Schauer NJ, Liu X, Hu W, Varca AC, Buhrlage SJ, Fischer ES.
Bushman JW, et al. Among authors: varca ac.
Cell Chem Biol. 2021 Jan 21;28(1):78-87.e3. doi: 10.1016/j.chembiol.2020.09.005. Epub 2020 Oct 1.
Cell Chem Biol. 2021.
PMID: 33007217
Free PMC article.
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Leukemia-specific delivery of mutant NOTCH1 targeted therapy.
Roti G, Qi J, Kitara S, Sanchez-Martin M, Saur Conway A, Varca AC, Su A, Wu L, Kung AL, Ferrando AA, Bradner JE, Stegmaier K.
Roti G, et al. Among authors: varca ac.
J Exp Med. 2018 Jan 2;215(1):197-216. doi: 10.1084/jem.20151778. Epub 2017 Nov 20.
J Exp Med. 2018.
PMID: 29158376
Free PMC article.
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Structure-guided DOT1L probe optimization by label-free ligand displacement.
Yi JS, Federation AJ, Qi J, Dhe-Paganon S, Hadler M, Xu X, St Pierre R, Varca AC, Wu L, Marineau JJ, Smith WB, Souza A, Chory EJ, Armstrong SA, Bradner JE.
Yi JS, et al. Among authors: varca ac.
ACS Chem Biol. 2015 Mar 20;10(3):667-74. doi: 10.1021/cb500796d. Epub 2015 Jan 15.
ACS Chem Biol. 2015.
PMID: 25397901
Free PMC article.
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