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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1980 2
1981 6
1982 10
1983 6
1984 10
1985 8
1986 10
1987 8
1988 27
1989 69
1990 95
1991 210
1992 215
1993 274
1994 393
1995 586
1996 712
1997 843
1998 950
1999 1039
2000 1115
2001 1150
2002 1118
2003 1156
2004 1198
2005 1187
2006 1199
2007 1186
2008 1165
2009 1196
2010 1283
2011 1318
2012 1318
2013 1299
2014 1307
2015 1371
2016 1265
2017 1177
2018 1139
2019 1275
2020 1317
2021 1238
2022 1041
2023 871
2024 193

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31,645 results

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Page 1
Cyclin-dependent kinases.
Malumbres M. Malumbres M. Genome Biol. 2014;15(6):122. doi: 10.1186/gb4184. Genome Biol. 2014. PMID: 25180339 Free PMC article. Review.
Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. ...
Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin
Cyclin-dependent kinases in DNA damage response.
Kciuk M, Gielecińska A, Mujwar S, Mojzych M, Kontek R. Kciuk M, et al. Biochim Biophys Acta Rev Cancer. 2022 May;1877(3):188716. doi: 10.1016/j.bbcan.2022.188716. Epub 2022 Mar 7. Biochim Biophys Acta Rev Cancer. 2022. PMID: 35271993 Free article. Review.
The cyclin-dependent kinase (CDK) family plays a critical role in a variety of signaling pathways that regulate transcription and cell-cycle progression. ...
The cyclin-dependent kinase (CDK) family plays a critical role in a variety of signaling pathways that regulate transcription …
The history and future of targeting cyclin-dependent kinases in cancer therapy.
Asghar U, Witkiewicz AK, Turner NC, Knudsen ES. Asghar U, et al. Nat Rev Drug Discov. 2015 Feb;14(2):130-46. doi: 10.1038/nrd4504. Nat Rev Drug Discov. 2015. PMID: 25633797 Free PMC article. Review.
Cancer represents a pathological manifestation of uncontrolled cell division; therefore, it has long been anticipated that our understanding of the basic principles of cell cycle control would result in effective cancer therapies. In particular, cyclin-dependent
Cancer represents a pathological manifestation of uncontrolled cell division; therefore, it has long been anticipated that our understanding …
When cyclin-dependent kinases meet viral infections, including SARS-CoV-2.
Yan Y, Tang YD, Zheng C. Yan Y, et al. J Med Virol. 2022 Jul;94(7):2962-2968. doi: 10.1002/jmv.27719. Epub 2022 Mar 23. J Med Virol. 2022. PMID: 35288942 Free PMC article. Review.
Cyclin-dependent kinases (CDKs) are protein kinases that play a key role in cell division and transcriptional regulation. ...
Cyclin-dependent kinases (CDKs) are protein kinases that play a key role in cell division and transcriptional re
Cyclin-dependent kinases in breast cancer: expression pattern and therapeutic implications.
Sofi S, Mehraj U, Qayoom H, Aisha S, Asdaq SMB, Almilaibary A, Mir MA. Sofi S, et al. Med Oncol. 2022 Apr 29;39(6):106. doi: 10.1007/s12032-022-01731-x. Med Oncol. 2022. PMID: 35486263 Review.
Cell cycle dysregulation is one of the hallmarks of cancer, resulting in uncontrolled cell proliferation. Cyclin-dependent kinases (CDKs) are central to the cell cycle control system, and deregulation of these kinases leads to the development of malign …
Cell cycle dysregulation is one of the hallmarks of cancer, resulting in uncontrolled cell proliferation. Cyclin-dependent
Cyclin-dependent kinases.
Harper JW, Adams PD. Harper JW, et al. Chem Rev. 2001 Aug;101(8):2511-26. doi: 10.1021/cr0001030. Chem Rev. 2001. PMID: 11749386 Review. No abstract available.
Inhibitors of Cyclin-Dependent Kinases: Types and Their Mechanism of Action.
Łukasik P, Baranowska-Bosiacka I, Kulczycka K, Gutowska I. Łukasik P, et al. Int J Mol Sci. 2021 Mar 10;22(6):2806. doi: 10.3390/ijms22062806. Int J Mol Sci. 2021. PMID: 33802080 Free PMC article. Review.
Recent studies on cyclin-dependent kinase (CDK) inhibitors have revealed that small molecule drugs have become very attractive for the treatment of cancer and neurodegenerative disorders. Most CDK inhibitors have been developed to target the ATP binding pocket. Howe …
Recent studies on cyclin-dependent kinase (CDK) inhibitors have revealed that small molecule drugs have become very attractive …
Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs.
Roskoski R Jr. Roskoski R Jr. Pharmacol Res. 2019 Jan;139:471-488. doi: 10.1016/j.phrs.2018.11.035. Epub 2018 Nov 30. Pharmacol Res. 2019. PMID: 30508677 Review.
Cyclins and cyclin-dependent protein kinases (CDKs) are important proteins that are required for the regulation and expression of the large number of components necessary for the passage through the cell cycle. ...Consequently, cells pass the G1-restriction p …
Cyclins and cyclin-dependent protein kinases (CDKs) are important proteins that are required for the regulation and exp …
Mammalian cyclin-dependent kinases.
Malumbres M, Barbacid M. Malumbres M, et al. Trends Biochem Sci. 2005 Nov;30(11):630-41. doi: 10.1016/j.tibs.2005.09.005. Epub 2005 Oct 19. Trends Biochem Sci. 2005. PMID: 16236519 Review.
Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian heterodimeric serine/threonine kinases that have been implicated in the control of cell-cycle progression, transcription and neuronal function. ...
Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian heterodimeric serine/threonine k
31,645 results
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