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Year Number of Results
1980 1
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2002 3
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2006 3
2007 4
2008 1
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218 results

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Macrophages and Alcohol-Related Liver Inflammation.
Ju C, Mandrekar P. Ju C, et al. Alcohol Res. 2015;37(2):251-62. Alcohol Res. 2015. PMID: 26717583 Free PMC article. Review.
Recent studies have suggested that macrophages have a critical role in the development of alcohol-induced inflammation in the liver. ...Findings point to the potential of macrophages as a therapeutic target in alcoholic liver injury. Futu …
Recent studies have suggested that macrophages have a critical role in the development of alcohol-induced inflammation …
IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease.
Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. Ma HY, et al. J Hepatol. 2020 May;72(5):946-959. doi: 10.1016/j.jhep.2019.12.016. Epub 2019 Dec 31. J Hepatol. 2020. PMID: 31899206 Free PMC article.
CONCLUSIONS: Overall, IL-17A is a tumor-promoting cytokine, which critically regulates alcohol-induced hepatic steatosis, inflammation, fibrosis, and HCC. LAY SUMMARY: IL-17A is a tumor-promoting cytokine, which critically regulates inflammatory responses in macr …
CONCLUSIONS: Overall, IL-17A is a tumor-promoting cytokine, which critically regulates alcohol-induced hepatic steatosis, inflamma …
CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease.
Duan Y, Chu H, Brandl K, Jiang L, Zeng S, Meshgin N, Papachristoforou E, Argemi J, Mendes BG, Wang Y, Su H, Sun W, Llorente C, Hendrikx T, Liu X, Hosseini M, Kisseleva T, Brenner DA, Bataller R, Ramachandran P, Karin M, Fu W, Schnabl B. Duan Y, et al. Nat Commun. 2021 Dec 9;12(1):7172. doi: 10.1038/s41467-021-27385-3. Nat Commun. 2021. PMID: 34887405 Free PMC article.
We previously associated cytolysin-positive Enterococcus faecalis with severity of alcohol-related liver disease. Here, we demonstrate that CRIg is reduced in liver tissues from patients with alcohol-related liver disease. CRIg-def …
We previously associated cytolysin-positive Enterococcus faecalis with severity of alcohol-related liver disease. Here, …
Pathogenesis of Alcohol-Associated Liver Disease.
Osna NA, Rasineni K, Ganesan M, Donohue TM Jr, Kharbanda KK. Osna NA, et al. J Clin Exp Hepatol. 2022 Nov-Dec;12(6):1492-1513. doi: 10.1016/j.jceh.2022.05.004. Epub 2022 May 31. J Clin Exp Hepatol. 2022. PMID: 36340300 Free PMC article. Review.
This is primarily because the liver is the first to see alcohol absorbed from the gastrointestinal tract via the portal circulation and second, because the liver is the principal site of ethanol metabolism. Alcohol-induced damage remains one of …
This is primarily because the liver is the first to see alcohol absorbed from the gastrointestinal tract via the portal circul …
Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice.
Ambade A, Lowe P, Kodys K, Catalano D, Gyongyosi B, Cho Y, Iracheta-Vellve A, Adejumo A, Saha B, Calenda C, Mehta J, Lefebvre E, Vig P, Szabo G. Ambade A, et al. Hepatology. 2019 Mar;69(3):1105-1121. doi: 10.1002/hep.30249. Epub 2019 Feb 12. Hepatology. 2019. PMID: 30179264 Free PMC article.
Kupffer cell and macrophage (MO) activation contributes to steatosis, inflammation, and fibrosis in alcoholic liver disease (ALD). ...We found that prevention and treatment with CVC reversed alcohol-related increases in liver mRNA and pro …
Kupffer cell and macrophage (MO) activation contributes to steatosis, inflammation, and fibrosis in alcoholic liver dis …
Interleukin-17 in Liver Disease Pathogenesis.
Li N, Yamamoto G, Fuji H, Kisseleva T. Li N, et al. Semin Liver Dis. 2021 Nov;41(4):507-515. doi: 10.1055/s-0041-1730926. Epub 2021 Jun 15. Semin Liver Dis. 2021. PMID: 34130335 Review.
Th17 cells differentiate from Th0 naive T-cells in response to transforming growth factor beta1 (TGF-beta1) and IL-6, the cytokines which also drive development of liver fibrosis, require activation of transcription factor retinoic acid receptor-related orphan nucle …
Th17 cells differentiate from Th0 naive T-cells in response to transforming growth factor beta1 (TGF-beta1) and IL-6, the cytokines which al …
Role of XBP1 in regulating the progression of non-alcoholic steatohepatitis.
Wang Q, Zhou H, Bu Q, Wei S, Li L, Zhou J, Zhou S, Su W, Liu M, Liu Z, Wang M, Lu L. Wang Q, et al. J Hepatol. 2022 Aug;77(2):312-325. doi: 10.1016/j.jhep.2022.02.031. Epub 2022 Mar 12. J Hepatol. 2022. PMID: 35292349 Free article.
Macrophage-specific Xbp1 knockout mice showed M2 anti-inflammatory polarization. Xbp1-deleted macrophages reduced steatohepatitis by decreasing the expression of NLRP3 and secretion of pro-inflammatory cytokines, which mediate M2 macrophage polarization in …
Macrophage-specific Xbp1 knockout mice showed M2 anti-inflammatory polarization. Xbp1-deleted macrophages reduced steatohepati …
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
Ceni E, Mello T, Galli A. Ceni E, et al. World J Gastroenterol. 2014 Dec 21;20(47):17756-72. doi: 10.3748/wjg.v20.i47.17756. World J Gastroenterol. 2014. PMID: 25548474 Free PMC article. Review.
Alcohol consumption is a predominant etiological factor in the pathogenesis of chronic liver diseases, resulting in fatty liver, alcoholic hepatitis, fibrosis/cirrhosis, and hepatocellular carcinoma (HCC). ...Ethanol metabolism may also interfer …
Alcohol consumption is a predominant etiological factor in the pathogenesis of chronic liver diseases, resulting in fatty l …
Macrophage-derived MLKL in alcohol-associated liver disease: Regulation of phagocytosis.
Wu X, Fan X, McMullen MR, Miyata T, Kim A, Pathak V, Wu J, Day LZ, Hardesty JE, Welch N, Dasarathy J, Allende DS, McCullough AJ, Jacobs JM, Rotroff DM, Dasarathy S, Nagy LE. Wu X, et al. Hepatology. 2023 Mar 1;77(3):902-919. doi: 10.1002/hep.32612. Epub 2023 Feb 17. Hepatology. 2023. PMID: 35689613 Free PMC article.
BACKGROUND AND AIMS: Mixed lineage kinase domain-like pseudokinase (MLKL), a key terminal effector of necroptosis, also plays a role in intracellular vesicle trafficking that is critical for regulating liver inflammation and injury in alcohol-associated li …
BACKGROUND AND AIMS: Mixed lineage kinase domain-like pseudokinase (MLKL), a key terminal effector of necroptosis, also plays a role in intr …
Myeloid-Cell-Specific IL-6 Signaling Promotes MicroRNA-223-Enriched Exosome Production to Attenuate NAFLD-Associated Fibrosis.
Hou X, Yin S, Ren R, Liu S, Yong L, Liu Y, Li Y, Zheng MH, Kunos G, Gao B, Wang H. Hou X, et al. Hepatology. 2021 Jul;74(1):116-132. doi: 10.1002/hep.31658. Epub 2021 Apr 27. Hepatology. 2021. PMID: 33236445 Free PMC article.
The role of IL-6 in NAFLD was investigated in Il6 knockout (KO) and Il6 receptor A (Il6ra) conditional KO mice after high-fat diet (HFD) feeding. HFD-fed Il6 KO mice had worse liver injury and fibrosis, but less inflammation, compared to wild-type mice. Hepatocyte-s …
The role of IL-6 in NAFLD was investigated in Il6 knockout (KO) and Il6 receptor A (Il6ra) conditional KO mice after high-fat diet (HFD) fee …
218 results