PubMed

Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation.

LoPachin RM, Gavin T, Petersen DR, Barber DS.

Chem Res Toxicol. 2009 Sep;22(9):1499-508.PMID: 19610654 [PubMed - in process]Related articles

In vitro and in silico characterization of peroxiredoxin 6 modified by 4-hydroxynonenal and 4-oxononenal.

Roede JR, Carbone DL, Doorn JA, Kirichenko OV, Reigan P, Petersen DR.

Chem Res Toxicol. 2008 Dec;21(12):2289-99.PMID: 19548352 [PubMed - indexed for MEDLINE]Related articles

Lipid aldehyde-mediated cross-linking of apolipoprotein B-100 inhibits secretion from HepG2 cells.

Stewart BJ, Roede JR, Doorn JA, Petersen DR.

Biochim Biophys Acta. 2009 Aug;1791(8):772-80. Epub 2009 Apr 21.PMID: 19393338 [PubMed - indexed for MEDLINE]Related articles

Overexpression of peroxiredoxin 6 does not prevent ethanol-mediated oxidative stress and may play a role in hepatic lipid accumulation.

Roede JR, Orlicky DJ, Fisher AB, Petersen DR.

J Pharmacol Exp Ther. 2009 Jul;330(1):79-88. Epub 2009 Apr 22.PMID: 19386791 [PubMed - indexed for MEDLINE]Related articles

In Vitro and in Silico Characterization of Peroxiredoxin 6 Modified by 4-Hydroxynonenal and 4-Oxononenal.

Roede JR, Carbone DL, Doorn JA, Kirichenko OV, Reigan P, Petersen DR.

Chem Res Toxicol. 2008 Oct 23. [Epub ahead of print]PMID: 18942798 [PubMed - as supplied by publisher]Related articles

Decreased expression of peroxiredoxin 6 in a mouse model of ethanol consumption.

Roede JR, Stewart BJ, Petersen DR.

Free Radic Biol Med. 2008 Dec 1;45(11):1551-8. Epub 2008 Sep 19.PMID: 18852041 [PubMed - indexed for MEDLINE]Related articles

Covalent binding of the nitroso metabolite of sulfamethoxazole is important in induction of drug-specific T-cell responses in vivo.

Cheng L, Stewart BJ, You Q, Petersen DR, Ware JA, Piccotti JR, Kawabata TT, Ju C.

Mol Pharmacol. 2008 Jun;73(6):1769-75. Epub 2008 Mar 11.PMID: 18334600 [PubMed - indexed for MEDLINE]Related articlesFree article

Residue-specific adduction of tubulin by 4-hydroxynonenal and 4-oxononenal causes cross-linking and inhibits polymerization.

Stewart BJ, Doorn JA, Petersen DR.

Chem Res Toxicol. 2007 Aug;20(8):1111-9. Epub 2007 Jul 13.PMID: 17630713 [PubMed - indexed for MEDLINE]Related articles

4-Hydroxy-2-nonenal adduction of extracellular signal-regulated kinase (Erk) and the inhibition of hepatocyte Erk-Est-like protein-1-activating protein-1 signal transduction.

Sampey BP, Carbone DL, Doorn JA, Drechsel DA, Petersen DR.

Mol Pharmacol. 2007 Mar;71(3):871-83. Epub 2006 Dec 12.PMID: 17164404 [PubMed - indexed for MEDLINE]Related articlesFree article

Ethanol-induced modulation of hepatocellular extracellular signal-regulated kinase-1/2 activity via 4-hydroxynonenal.

Sampey BP, Stewart BJ, Petersen DR.

J Biol Chem. 2007 Jan 19;282(3):1925-37. Epub 2006 Nov 15.PMID: 17107949 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of phosphatidylinositol 3-kinase and extracellular-regulated kinase in hepatic stellate cell antioxidant response and myofibroblastic transdifferentiation.

Reichard JF, Petersen DR.

Arch Biochem Biophys. 2006 Feb 15;446(2):111-8. Epub 2006 Jan 11.PMID: 16455043 [PubMed - indexed for MEDLINE]Related articles

Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal.

Doorn JA, Hurley TD, Petersen DR.

Chem Res Toxicol. 2006 Jan;19(1):102-10.PMID: 16411662 [PubMed - indexed for MEDLINE]Related articles

CYP2E1 and catalase influence ethanol sensitivity in the central nervous system.

Vasiliou V, Ziegler TL, Bludeau P, Petersen DR, Gonzalez FJ, Deitrich RA.

Pharmacogenet Genomics. 2006 Jan;16(1):51-8.PMID: 16344722 [PubMed - indexed for MEDLINE]Related articles

Cysteine modification by lipid peroxidation products inhibits protein disulfide isomerase.

Carbone DL, Doorn JA, Kiebler Z, Petersen DR.

Chem Res Toxicol. 2005 Aug;18(8):1324-31.PMID: 16097806 [PubMed - indexed for MEDLINE]Related articles

Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition.

Ronis MJ, Butura A, Sampey BP, Shankar K, Prior RL, Korourian S, Albano E, Ingelman-Sundberg M, Petersen DR, Badger TM.

Free Radic Biol Med. 2005 Sep 1;39(5):619-30.PMID: 16085180 [PubMed - indexed for MEDLINE]Related articles

Alcohol, iron-associated oxidative stress, and cancer.

Petersen DR.

Alcohol. 2005 Apr;35(3):243-9. Review.PMID: 16054986 [PubMed - indexed for MEDLINE]Related articles

Modification of heat shock protein 90 by 4-hydroxynonenal in a rat model of chronic alcoholic liver disease.

Carbone DL, Doorn JA, Kiebler Z, Ickes BR, Petersen DR.

J Pharmacol Exp Ther. 2005 Oct;315(1):8-15. Epub 2005 Jun 10.PMID: 15951401 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of Hsp72-mediated protein refolding by 4-hydroxy-2-nonenal.

Carbone DL, Doorn JA, Kiebler Z, Sampey BP, Petersen DR.

Chem Res Toxicol. 2004 Nov;17(11):1459-67.PMID: 15540944 [PubMed - indexed for MEDLINE]Related articles

Human carbonyl reductase catalyzes reduction of 4-oxonon-2-enal.

Doorn JA, Maser E, Blum A, Claffey DJ, Petersen DR.

Biochemistry. 2004 Oct 19;43(41):13106-14.PMID: 15476404 [PubMed - indexed for MEDLINE]Related articles

4-Hydroxynonenal regulates 26S proteasomal degradation of alcohol dehydrogenase.

Carbone DL, Doorn JA, Petersen DR.

Free Radic Biol Med. 2004 Nov 1;37(9):1430-9.PMID: 15454282 [PubMed - indexed for MEDLINE]Related articles