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    Results: 1 to 20 of 42

    1.

    Cisplatin-induced DNA damage activates replication checkpoint signaling components that differentially affect tumor cell survival.

    Wagner JM, Karnitz LM.

    Mol Pharmacol. 2009 Jul;76(1):208-14. Epub 2009 Apr 29.PMID: 19403702 [PubMed - indexed for MEDLINE]Related articles

    2.

    Sonic Hedgehog signaling impairs ionizing radiation-induced checkpoint activation and induces genomic instability.

    Leonard JM, Ye H, Wetmore C, Karnitz LM.

    J Cell Biol. 2008 Nov 3;183(3):385-91. Epub 2008 Oct 27.PMID: 18955550 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Overcoming S-phase checkpoint-mediated resistance: sequence-dependent synergy of gemcitabine and 7-ethyl-10-hydroxycamptothecin (SN-38) in human carcinoma cell lines.

    Gálvez-Peralta M, Dai NT, Loegering DA, Flatten KS, Safgren SL, Wagner JM, Ames MM, Karnitz LM, Kaufmann SH.

    Mol Pharmacol. 2008 Sep;74(3):724-35. Epub 2008 May 28.PMID: 18509065 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase I.

    Hackbarth JS, Galvez-Peralta M, Dai NT, Loegering DA, Peterson KL, Meng XW, Karnitz LM, Kaufmann SH.

    J Biol Chem. 2008 Jun 13;283(24):16711-22. Epub 2008 Apr 11.PMID: 18408216 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Functioning of the Hsp90 machine in chaperoning checkpoint kinase I (Chk1) and the progesterone receptor (PR).

    Felts SJ, Karnitz LM, Toft DO.

    Cell Stress Chaperones. 2007 Winter;12(4):353-63.PMID: 18229454 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

    Delacroix S, Wagner JM, Kobayashi M, Yamamoto K, Karnitz LM.

    Genes Dev. 2007 Jun 15;21(12):1472-7.PMID: 17575048 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Cdc37 regulation of the kinome: when to hold 'em and when to fold 'em.

    Karnitz LM, Felts SJ.

    Sci STKE. 2007 May 8;2007(385):pe22. Review.PMID: 17488976 [PubMed - indexed for MEDLINE]Related articles

    8.

    Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones.

    Arlander SJ, Felts SJ, Wagner JM, Stensgard B, Toft DO, Karnitz LM.

    J Biol Chem. 2006 Feb 3;281(5):2989-98. Epub 2005 Dec 5.PMID: 16330544 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival.

    Karnitz LM, Flatten KS, Wagner JM, Loegering D, Hackbarth JS, Arlander SJ, Vroman BT, Thomas MB, Baek YU, Hopkins KM, Lieberman HB, Chen J, Cliby WA, Kaufmann SH.

    Mol Pharmacol. 2005 Dec;68(6):1636-44. Epub 2005 Aug 26.PMID: 16126823 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine.

    Mesa RA, Loegering D, Powell HL, Flatten K, Arlander SJ, Dai NT, Heldebrant MP, Vroman BT, Smith BD, Karp JE, Eyck CJ, Erlichman C, Kaufmann SH, Karnitz LM.

    Blood. 2005 Jul 1;106(1):318-27. Epub 2005 Mar 22.PMID: 15784732 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons.

    Flatten K, Dai NT, Vroman BT, Loegering D, Erlichman C, Karnitz LM, Kaufmann SH.

    J Biol Chem. 2005 Apr 8;280(14):14349-55. Epub 2005 Feb 7.PMID: 15699047 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    S-peptide epitope tagging for protein purification, expression monitoring, and localization in mammalian cells.

    Hackbarth JS, Lee SH, Meng XW, Vroman BT, Kaufmann SH, Karnitz LM.

    Biotechniques. 2004 Nov;37(5):835-9.PMID: 15560139 [PubMed - indexed for MEDLINE]Related articles

    13.

    Rad9 protects cells from topoisomerase poison-induced cell death.

    Loegering D, Arlander SJ, Hackbarth J, Vroman BT, Roos-Mattjus P, Hopkins KM, Lieberman HB, Karnitz LM, Kaufmann SH.

    J Biol Chem. 2004 Apr 30;279(18):18641-7. Epub 2004 Feb 25.PMID: 14988409 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Purification and identification of protein complexes that control the cell cycle.

    Burtelow MA, Podust VN, Karnitz LM.

    Methods Mol Biol. 2004;241:247-53. No abstract available. PMID: 14970659 [PubMed - indexed for MEDLINE]Related articles

    15.

    Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene.

    Dufault VM, Oestreich AJ, Vroman BT, Karnitz LM.

    Genomics. 2003 Dec;82(6):644-51.PMID: 14611806 [PubMed - indexed for MEDLINE]Related articles

    16.

    Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress.

    Arlander SJ, Eapen AK, Vroman BT, McDonald RJ, Toft DO, Karnitz LM.

    J Biol Chem. 2003 Dec 26;278(52):52572-7. Epub 2003 Oct 21.PMID: 14570880 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Cut5 is required for the binding of Atr and DNA polymerase alpha to genotoxin-damaged chromatin.

    Parrilla-Castellar ER, Karnitz LM.

    J Biol Chem. 2003 Nov 14;278(46):45507-11. Epub 2003 Oct 2.PMID: 14525986 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment.

    Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J.

    J Biol Chem. 2003 Aug 8;278(32):30051-6. Epub 2003 May 23.PMID: 12766176 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling.

    Roos-Mattjus P, Hopkins KM, Oestreich AJ, Vroman BT, Johnson KL, Naylor S, Lieberman HB, Karnitz LM.

    J Biol Chem. 2003 Jul 4;278(27):24428-37. Epub 2003 Apr 21.PMID: 12709442 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event.

    Roos-Mattjus P, Vroman BT, Burtelow MA, Rauen M, Eapen AK, Karnitz LM.

    J Biol Chem. 2002 Nov 15;277(46):43809-12. Epub 2002 Sep 11.PMID: 12228248 [PubMed - indexed for MEDLINE]Related articlesFree article

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