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    Results: 1 to 20 of 325

    1.

    Creation and characterization of a mitochondrial DNA-depleted pancreatic beta-cell line: impaired insulin secretion induced by glucose, leucine, and sulfonylureas.

    Tsuruzoe K, Araki E, Furukawa N, Shirotani T, Matsumoto K, Kaneko K, Motoshima H, Yoshizato K, Shirakami A, Kishikawa H, Miyazaki J, Shichiri M.

    Diabetes. 1998 Apr;47(4):621-31.PMID: 9568696 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Mitochondrial DNA is required for regulation of glucose-stimulated insulin secretion in a mouse pancreatic beta cell line, MIN6.

    Soejima A, Inoue K, Takai D, Kaneko M, Ishihara H, Oka Y, Hayashi JI.

    J Biol Chem. 1996 Oct 18;271(42):26194-9.PMID: 8824267 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.

    Pongratz RL, Kibbey RG, Kirkpatrick CL, Zhao X, Pontoglio M, Yaniv M, Wollheim CB, Shulman GI, Cline GW.

    J Biol Chem. 2009 Jun 19;284(25):16808-21. Epub 2009 Apr 17.PMID: 19376774 [PubMed - indexed for MEDLINE]Related articles

    4.

    Depletion of mitochondrial DNA causes impaired glucose utilization and insulin resistance in L6 GLUT4myc myocytes.

    Park SY, Choi GH, Choi HI, Ryu J, Jung CY, Lee W.

    J Biol Chem. 2005 Mar 18;280(11):9855-64. Epub 2004 Dec 17.PMID: 15764607 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Switch to anaerobic glucose metabolism with NADH accumulation in the beta-cell model of mitochondrial diabetes. Characteristics of betaHC9 cells deficient in mitochondrial DNA transcription.

    Noda M, Yamashita S, Takahashi N, Eto K, Shen LM, Izumi K, Daniel S, Tsubamoto Y, Nemoto T, Iino M, Kasai H, Sharp GW, Kadowaki T.

    J Biol Chem. 2002 Nov 1;277(44):41817-26. Epub 2002 Aug 6.PMID: 12169697 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Glucose induces calcium-dependent and calcium-independent insulin secretion from the pancreatic beta cell line MIN6.

    Sakuma N, Ishikawa S, Okada K, Miyazaki J, Saito T.

    Eur J Endocrinol. 1995 Aug;133(2):227-34.PMID: 7655649 [PubMed - indexed for MEDLINE]Related articles

    7.

    Ethidium bromide-induced inhibition of mitochondrial gene transcription suppresses glucose-stimulated insulin release in the mouse pancreatic beta-cell line betaHC9.

    Hayakawa T, Noda M, Yasuda K, Yorifuji H, Taniguchi S, Miwa I, Sakura H, Terauchi Y, Hayashi J, Sharp GW, Kanazawa Y, Akanuma Y, Yazaki Y, Kadowaki T.

    J Biol Chem. 1998 Aug 7;273(32):20300-7.PMID: 9685380 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Impaired insulin secretion by diphenyleneiodium associated with perturbation of cytosolic Ca2+ dynamics in pancreatic beta-cells.

    Imoto H, Sasaki N, Iwase M, Nakamura U, Oku M, Sonoki K, Uchizono Y, Iida M.

    Endocrinology. 2008 Nov;149(11):5391-400. Epub 2008 Jul 10.PMID: 18617620 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    ACTH stimulates insulin secretion from MIN6 cells and primary mouse and human islets of Langerhans.

    Al-Majed HT, Jones PM, Persaud SJ, Sugden D, Huang GC, Amiel S, Whitehouse BJ.

    J Endocrinol. 2004 Jan;180(1):155-66.PMID: 14709154 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells.

    Porzio O, Federici M, Hribal ML, Lauro D, Accili D, Lauro R, Borboni P, Sesti G.

    J Clin Invest. 1999 Aug;104(3):357-64.PMID: 10430617 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets.

    Ishihara H, Asano T, Tsukuda K, Katagiri H, Inukai K, Anai M, Kikuchi M, Yazaki Y, Miyazaki JI, Oka Y.

    Diabetologia. 1993 Nov;36(11):1139-45.PMID: 8270128 [PubMed - indexed for MEDLINE]Related articles

    12.

    Differential sensitivity to beta-cell secretagogues in cultured rat pancreatic islets exposed to human interleukin-1 beta.

    Eizirik DL, Sandler S, Hallberg A, Bendtzen K, Sener A, Malaisse WJ.

    Endocrinology. 1989 Aug;125(2):752-9.PMID: 2666106 [PubMed - indexed for MEDLINE]Related articles

    13.

    Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.

    Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I.

    J Biol Chem. 2006 Feb 24;281(8):5246-57. Epub 2005 Dec 23.PMID: 16377800 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Effect of mitochondrial and/or cytosolic glycerol 3-phosphate dehydrogenase overexpression on glucose-stimulated insulin secretion from MIN6 and HIT cells.

    Ishihara H, Nakazaki M, Kanegae Y, Inukai K, Asano T, Katagiri H, Yazaki Y, Kikuchi M, Miyazaki J, Saito I, Oka Y.

    Diabetes. 1996 Sep;45(9):1238-44.PMID: 8772729 [PubMed - indexed for MEDLINE]Related articles

    15.

    The depletion of cellular mitochondrial DNA causes insulin resistance through the alteration of insulin receptor substrate-1 in rat myocytes.

    Park SY, Lee W.

    Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S165-71. Epub 2007 Apr 25.PMID: 17462778 [PubMed - indexed for MEDLINE]Related articles

    16.

    Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion.

    Wang H, Maechler P, Antinozzi PA, Hagenfeldt KA, Wollheim CB.

    J Biol Chem. 2000 Nov 17;275(46):35953-9.PMID: 10967120 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    A novel enhancer of insulinotrophic action by high glucose (JTT-608) stimulates insulin secretion from pancreatic beta-cells via a new cellular mechanism.

    Itabashi N, Okada K, Muto S, Fujita N, Ohta T, Miyazaki Ji, Asano Y, Saito T.

    J Pharmacol Exp Ther. 2001 Jun;297(3):953-60.PMID: 11356916 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Leucine culture reveals that ATP synthase functions as a fuel sensor in pancreatic beta-cells.

    Yang J, Wong RK, Wang X, Moibi J, Hessner MJ, Greene S, Wu J, Sukumvanich S, Wolf BA, Gao Z.

    J Biol Chem. 2004 Dec 24;279(52):53915-23. Epub 2004 Oct 14.PMID: 15489222 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Overexpression of hexokinase I but not GLUT1 glucose transporter alters concentration dependence of glucose-stimulated insulin secretion in pancreatic beta-cell line MIN6.

    Ishihara H, Asano T, Tsukuda K, Katagiri H, Inukai K, Anai M, Kikuchi M, Yazaki Y, Miyazaki J, Oka Y.

    J Biol Chem. 1994 Jan 28;269(4):3081-7.PMID: 8300643 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.

    Wang H, Maechler P, Hagenfeldt KA, Wollheim CB.

    EMBO J. 1998 Nov 16;17(22):6701-13.PMID: 9822613 [PubMed - indexed for MEDLINE]Related articlesFree article

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