PubMed

Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer.

Vadhan-Raj S, Murray LJ, Bueso-Ramos C, Patel S, Reddy SP, Hoots WK, Johnston T, Papadopolous NE, Hittelman WN, Johnston DA, Yang TA, Paton VE, Cohen RL, Hellmann SD, Benjamin RS, Broxmeyer HE.

Ann Intern Med. 1997 May 1;126(9):673-81.PMID: 9139552 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer.

Vadhan-Raj S, Verschraegen CF, Bueso-Ramos C, Broxmeyer HE, Kudelkà AP, Freedman RS, Edwards CL, Gershenson D, Jones D, Ashby M, Kavanagh JJ.

Ann Intern Med. 2000 Mar 7;132(5):364-8.PMID: 10691586 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of thrombocytopenia and neutropenia in a nonhuman primate model of marrow suppressive chemotherapy by combining pegylated recombinant human megakaryocyte growth and development factor and recombinant human granulocyte colony-stimulating factor.

Harker LA, Marzec UM, Kelly AB, Cheung E, Tomer A, Nichol JL, Hanson SR, Stead RB.

Blood. 1997 Jan 1;89(1):155-65.PMID: 8978288 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates.

Harker LA, Hunt P, Marzec UM, Kelly AB, Tomer A, Hanson SR, Stead RB.

Blood. 1996 Mar 1;87(5):1833-44.PMID: 8634430 [PubMed - indexed for MEDLINE]Related articlesFree article

Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates.

Harker LA, Marzec UM, Hunt P, Kelly AB, Tomer A, Cheung E, Hanson SR, Stead RB.

Blood. 1996 Jul 15;88(2):511-21.PMID: 8695799 [PubMed - indexed for MEDLINE]Related articlesFree article

Thrombocytopenia after high-dose chemotherapy and autologous stem cell transplantation: an unresolved problem and possible approaches to resolve it.

Hassan HT, Zander AR.

J Hematother. 1996 Aug;5(4):407-14. Review.PMID: 8877716 [PubMed - indexed for MEDLINE]Related articles

The effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet recovery in breast cancer patients undergoing autologous bone marrow transplantation.

Schuster MW, Beveridge R, Frei-Lahr D, Abboud CN, Cruickshank S, Macri M, Menchaca D, Holden J, Waller EK.

Exp Hematol. 2002 Sep;30(9):1044-50.PMID: 12225796 [PubMed - indexed for MEDLINE]Related articles

Recombinant human thrombopoietin (rhTPO) after autologous bone marrow transplantation: a phase I pharmacokinetic and pharmacodynamic study.

Wolff SN, Herzig R, Lynch J, Ericson SG, Greer JP, Stein R, Goodman S, Benyunes MC, Ashby M, Jones DV Jr, Fay J.

Bone Marrow Transplant. 2001 Feb;27(3):261-8.PMID: 11277173 [PubMed - indexed for MEDLINE]Related articlesFree article

A single intravenous dose of murine megakaryocyte growth and development factor potently stimulates platelet production, challenging the necessity for daily administration.

Daw NC, Arnold JT, Abushullaih BA, Stenberg PE, White MM, Jayawardene D, Srivastava DK, Jackson CW.

Blood. 1998 Jan 15;91(2):466-74.PMID: 9427699 [PubMed - indexed for MEDLINE]Related articlesFree article

The prolonged hematologic effects of a single injection of PEG-rHuMGDF in normal and thrombocytopenic mice.

Ulich TR, del Castillo J, Senaldi G, Cheung E, Roskos L, Young J, Molineux G, Guo J, Schoemperlen J, Munyakazi L, Murphy-Filkins R, Tarpley JE, Toombs CF, Kaufman S, Yin S, Nelson AG, Nichol JL, Sheridan WP.

Exp Hematol. 1999 Jan;27(1):117-30.PMID: 9923450 [PubMed - indexed for MEDLINE]Related articles

Thrombopoietin: biology and potential clinical applications.

Prow D, Vadhan-Raj S.

Oncology (Williston Park). 1998 Nov;12(11):1597-604, 1607-8; discussion 1611-4. Review.PMID: 9834938 [PubMed - indexed for MEDLINE]Related articles

A phase I trial of recombinant human thrombopoietin in patients with delayed platelet recovery after hematopoietic stem cell transplantation.

Nash RA, Kurzrock R, DiPersio J, Vose J, Linker C, Maharaj D, Nademanee AP, Negrin R, Nimer S, Shulman H, Ashby M, Jones D, Appelbaum FR, Champlin R.

Biol Blood Marrow Transplant. 2000;6(1):25-34.PMID: 10707996 [PubMed - indexed for MEDLINE]Related articles

In vivo effects of pegylated recombinant human megakaryocyte growth and development factor on hematopoiesis in normal mice.

Kabaya K, Akahori H, Shibuya K, Nitta Y, Ida M, Kusaka M, Kato T, Miyazaki H.

Stem Cells. 1996 Nov;14(6):651-60.PMID: 8948023 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical experience with recombinant human thrombopoietin in chemotherapy-induced thrombocytopenia.

Vadhan-Raj S.

Semin Hematol. 2000 Apr;37(2 Suppl 4):28-34. Review.PMID: 10831286 [PubMed - indexed for MEDLINE]Related articles

Recombinant human thrombopoietin in myelosuppressive chemotherapy.

Vadhan-Raj S.

Oncology (Williston Park). 2001 Jul;15(7 Suppl 8):35-8.PMID: 11497230 [PubMed - indexed for MEDLINE]Related articles

Thrombopoietin mobilizes CD34+ cell subsets into peripheral blood and expands multilineage progenitors in bone marrow of cancer patients with normal hematopoiesis.

Murray LJ, Luens KM, Estrada MF, Bruno E, Hoffman R, Cohen RL, Ashby MA, Vadhan-Raj S.

Exp Hematol. 1998 Mar;26(3):207-16.PMID: 9502616 [PubMed - indexed for MEDLINE]Related articles

Recombinant human thrombopoietin: clinical experience and in vivo biology.

Vadhan-Raj S.

Semin Hematol. 1998 Jul;35(3):261-8. Review.PMID: 9685172 [PubMed - indexed for MEDLINE]Related articles

Constant subcutaneous infusion of rhIL-11 in mice: efficient delivery enhances biological activity.

Leonard JP, Neben TY, Kozitza MK, Quinto CM, Goldman SJ.

Exp Hematol. 1996 Feb;24(2):270-6.PMID: 8641352 [PubMed - indexed for MEDLINE]Related articles

Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer.

Basser RL, Rasko JE, Clarke K, Cebon J, Green MD, Hussein S, Alt C, Menchaca D, Tomita D, Marty J, Fox RM, Begley CG.

Lancet. 1996 Nov 9;348(9037):1279-81.PMID: 8909381 [PubMed - indexed for MEDLINE]Related articles

Multilineage hematopoietic recovery by a single injection of pegylated recombinant human megakaryocyte growth and development factor in myelosuppressed mice.

Shibuya K, Akahori H, Takahashi K, Tahara E, Kato T, Miyazaki H.

Blood. 1998 Jan 1;91(1):37-45.PMID: 9414267 [PubMed - indexed for MEDLINE]Related articlesFree article