PubMed

Bcl-2 expressed using a retroviral vector is localized primarily in the nuclear membrane and the endoplasmic reticulum of chicken embryo fibroblasts.

Givol I, Tsarfaty I, Resau J, Rulong S, da Silva PP, Nasioulas G, DuHadaway J, Hughes SH, Ewert DL.

Cell Growth Differ. 1994 Apr;5(4):419-29.PMID: 8043516 [PubMed - indexed for MEDLINE]Related articlesFree article

The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane.

Lithgow T, van Driel R, Bertram JF, Strasser A.

Cell Growth Differ. 1994 Apr;5(4):411-7.PMID: 8043515 [PubMed - indexed for MEDLINE]Related articlesFree article

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

Krajewski S, Tanaka S, Takayama S, Schibler MJ, Fenton W, Reed JC.

Cancer Res. 1993 Oct 1;53(19):4701-14.PMID: 8402648 [PubMed - indexed for MEDLINE]Related articles

Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes.

Akao Y, Otsuki Y, Kataoka S, Ito Y, Tsujimoto Y.

Cancer Res. 1994 May 1;54(9):2468-71.PMID: 8162596 [PubMed - indexed for MEDLINE]Related articlesFree article

NSAID-induced apoptosis in Rous sarcoma virus-transformed chicken embryo fibroblasts is dependent on v-src and c-myc and is inhibited by bcl-2.

Lu X, Fairbairn DW, Bradshaw WS, O'Neill KL, Ewert DL, Simmons DL.

Prostaglandins. 1997 Aug;54(2):549-68.PMID: 9380798 [PubMed - indexed for MEDLINE]Related articles

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.

Zhu W, Cowie A, Wasfy GW, Penn LZ, Leber B, Andrews DW.

EMBO J. 1996 Aug 15;15(16):4130-41.PMID: 8861942 [PubMed - indexed for MEDLINE]Related articlesFree article

Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event.

Annis MG, Zamzami N, Zhu W, Penn LZ, Kroemer G, Leber B, Andrews DW.

Oncogene. 2001 Apr 12;20(16):1939-52.PMID: 11360178 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of chicken c-ski oncogene products expressed by retrovirus vectors.

Sutrave P, Copeland TD, Showalter SD, Hughes SH.

Mol Cell Biol. 1990 Jun;10(6):3137-44.PMID: 2188109 [PubMed - indexed for MEDLINE]Related articlesFree article

Localization of the Bcl-2 protein to the outer mitochondrial membrane by electron microscopy.

Riparbelli MG, Callaini G, Tripodi SA, Cintorino M, Tosi P, Dallai R.

Exp Cell Res. 1995 Dec;221(2):363-9.PMID: 7493635 [PubMed - indexed for MEDLINE]Related articles

Transient expression of wild-type or mitochondrially targeted Bcl-2 induces apoptosis, whereas transient expression of endoplasmic reticulum-targeted Bcl-2 is protective against Bax-induced cell death.

Wang NS, Unkila MT, Reineks EZ, Distelhorst CW.

J Biol Chem. 2001 Nov 23;276(47):44117-28. Epub 2001 Sep 6.PMID: 11546793 [PubMed - indexed for MEDLINE]Related articlesFree article

Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts.

Lee ST, Hoeflich KP, Wasfy GW, Woodgett JR, Leber B, Andrews DW, Hedley DW, Penn LZ.

Oncogene. 1999 Jun 10;18(23):3520-8.PMID: 10376530 [PubMed - indexed for MEDLINE]Related articlesFree article

Bcl-2 and Bax proteins are present in interphase nuclei of mammalian cells.

Hoetelmans R, van Slooten HJ, Keijzer R, Erkeland S, van de Velde CJ, Dierendonck JH.

Cell Death Differ. 2000 Apr;7(4):384-92.PMID: 10773823 [PubMed - indexed for MEDLINE]Related articlesFree article

c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL.

Maclean KH, Keller UB, Rodriguez-Galindo C, Nilsson JA, Cleveland JL.

Mol Cell Biol. 2003 Oct;23(20):7256-70.PMID: 14517295 [PubMed - indexed for MEDLINE]Related articlesFree article

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53.

Li J, Lee B, Lee AS.

J Biol Chem. 2006 Mar 17;281(11):7260-70. Epub 2006 Jan 6.PMID: 16407291 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of BAX in cell nucleus after experimentally induced apoptosis revealed by immunogold and embedment-free electron microscopy.

Gajkowska B, Motyl T, Olszewska-Badarczuk H, Godlewski MM.

Cell Biol Int. 2001;25(8):725-33.PMID: 11482896 [PubMed - indexed for MEDLINE]Related articles

Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast.

Xu Q, Reed JC.

Mol Cell. 1998 Feb;1(3):337-46.PMID: 9660918 [PubMed - indexed for MEDLINE]Related articles

During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria.

Kim PK, Annis MG, Dlugosz PJ, Leber B, Andrews DW.

Mol Cell. 2004 May 21;14(4):523-9.PMID: 15149601 [PubMed - indexed for MEDLINE]Related articles

Bcl-2 expression in synovial fibroblasts is essential for maintaining mitochondrial homeostasis and cell viability.

Perlman H, Georganas C, Pagliari LJ, Koch AE, Haines K 3rd, Pope RM.

J Immunol. 2000 May 15;164(10):5227-35.PMID: 10799883 [PubMed - indexed for MEDLINE]Related articlesFree article

Ultrastructural localization of bcl-2 protein.

Monaghan P, Robertson D, Amos TA, Dyer MJ, Mason DY, Greaves MF.

J Histochem Cytochem. 1992 Dec;40(12):1819-25.PMID: 1453000 [PubMed - indexed for MEDLINE]Related articlesFree article

Myc potentiates apoptosis by stimulating Bax activity at the mitochondria.

Soucie EL, Annis MG, Sedivy J, Filmus J, Leber B, Andrews DW, Penn LZ.

Mol Cell Biol. 2001 Jul;21(14):4725-36.PMID: 11416148 [PubMed - indexed for MEDLINE]Related articlesFree article