PubMed

Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial.

Morgan SL, Baggott JE, Vaughn WH, Austin JS, Veitch TA, Lee JY, Koopman WJ, Krumdieck CL, Alarcón GS.

Ann Intern Med. 1994 Dec 1;121(11):833-41.PMID: 7978695 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a forty-eight week, multicenter, randomized, double-blind, placebo-controlled study.

van Ede AE, Laan RF, Rood MJ, Huizinga TW, van de Laar MA, van Denderen CJ, Westgeest TA, Romme TC, de Rooij DJ, Jacobs MJ, de Boo TM, van der Wilt GJ, Severens JL, Hartman M, Krabbe PF, Dijkmans BA, Breedveld FC, van de Putte LB.

Arthritis Rheum. 2001 Jul;44(7):1515-24.PMID: 11465701 [PubMed - indexed for MEDLINE]Related articlesFree article

Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis.

van Ede AE, Laan RF, Blom HJ, Boers GH, Haagsma CJ, Thomas CM, De Boo TM, van de Putte LB.

Rheumatology (Oxford). 2002 Jun;41(6):658-65.PMID: 12048292 [PubMed - indexed for MEDLINE]Related articlesFree article

Do patients with rheumatoid arthritis established on methotrexate and folic acid 5 mg daily need to continue folic acid supplements long term?

Griffith SM, Fisher J, Clarke S, Montgomery B, Jones PW, Saklatvala J, Dawes PT, Shadforth MF, Hothersall TE, Hassell AB, Hay EM.

Rheumatology (Oxford). 2000 Oct;39(10):1102-9.PMID: 11035130 [PubMed - indexed for MEDLINE]Related articlesFree article

Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease prevention.

Morgan SL, Baggott JE, Lee JY, Alarcón GS.

J Rheumatol. 1998 Mar;25(3):441-6.PMID: 9517760 [PubMed - indexed for MEDLINE]Related articles

The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis.

Morgan SL, Baggott JE, Vaughn WH, Young PK, Austin JV, Krumdieck CL, Alarcón GS.

Arthritis Rheum. 1990 Jan;33(1):9-18.PMID: 2405864 [PubMed - indexed for MEDLINE]Related articles

Folate, homocysteine, and cobalamin status in patients with rheumatoid arthritis treated with methotrexate, and the effect of low dose folic acid supplement.

Hornung N, Ellingsen T, Stengaard-Pedersen K, Poulsen JH.

J Rheumatol. 2004 Dec;31(12):2374-81.PMID: 15570637 [PubMed - indexed for MEDLINE]Related articles

The effects of daily intake of folic acid on the efficacy of methotrexate therapy in children with juvenile rheumatoid arthritis. A controlled study.

Hunt PG, Rose CD, McIlvain-Simpson G, Tejani S.

J Rheumatol. 1997 Nov;24(11):2230-2.PMID: 9375889 [PubMed - indexed for MEDLINE]Related articles

Economic evaluation of folate supplementation during methotrexate treatment in rheumatoid arthritis.

Hartman M, van Ede A, Severens JL, Laan RF, van de Putte L, van der Wilt GJ.

J Rheumatol. 2004 May;31(5):902-8.PMID: 15124248 [PubMed - indexed for MEDLINE]Related articles

Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.

Ortiz Z, Shea B, Suarez Almazor M, Moher D, Wells G, Tugwell P.

Cochrane Database Syst Rev. 2000;(2):CD000951. Review.PMID: 10796393 [PubMed - indexed for MEDLINE]Related articles

Efficacy, pharmacokinetic, and safety assessment of adalimumab, a fully human anti-tumor necrosis factor-alpha monoclonal antibody, in adults with rheumatoid arthritis receiving concomitant methotrexate: a pilot study.

Weisman MH, Moreland LW, Furst DE, Weinblatt ME, Keystone EC, Paulus HE, Teoh LS, Velagapudi RB, Noertersheuser PA, Granneman GR, Fischkoff SA, Chartash EK.

Clin Ther. 2003 Jun;25(6):1700-21.PMID: 12860493 [PubMed - indexed for MEDLINE]Related articles

The efficacy of folic acid and folinic acid in reducing methotrexate gastrointestinal toxicity in rheumatoid arthritis. A metaanalysis of randomized controlled trials.

Ortiz Z, Shea B, Suarez-Almazor ME, Moher D, Wells GA, Tugwell P.

J Rheumatol. 1998 Jan;25(1):36-43.PMID: 9458200 [PubMed - indexed for MEDLINE]Related articles

Reduction of the efficacy of methotrexate by the use of folic acid: post hoc analysis from two randomized controlled studies.

Khanna D, Park GS, Paulus HE, Simpson KM, Elashoff D, Cohen SB, Emery P, Dorrier C, Furst DE.

Arthritis Rheum. 2005 Oct;52(10):3030-8.PMID: 16200612 [PubMed - indexed for MEDLINE]Related articlesFree article

Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. A randomized, double-blind, placebo-controlled trial.

Kremer JM, Genovese MC, Cannon GW, Caldwell JR, Cush JJ, Furst DE, Luggen ME, Keystone E, Weisman MH, Bensen WM, Kaine JL, Ruderman EM, Coleman P, Curtis DL, Kopp EJ, Kantor SM, Waltuck J, Lindsley HB, Markenson JA, Strand V, Crawford B, Fernando I, Simpson K, Bathon JM.

Ann Intern Med. 2002 Nov 5;137(9):726-33.PMID: 12416946 [PubMed - indexed for MEDLINE]Related articlesFree article

Homocysteine levels in patients with rheumatoid arthritis treated with low-dose methotrexate.

Morgan SL, Baggott JE, Refsum H, Ueland PM.

Clin Pharmacol Ther. 1991 Nov;50(5 Pt 1):547-56.PMID: 1934868 [PubMed - indexed for MEDLINE]Related articles

Folic acid supplementation during treatment of psoriasis with methotrexate: a randomized, double-blind, placebo-controlled trial.

Salim A, Tan E, Ilchyshyn A, Berth-Jones J.

Br J Dermatol. 2006 Jun;154(6):1169-74.PMID: 16704650 [PubMed - indexed for MEDLINE]Related articles

Efficacy of tacrolimus in rheumatoid arthritis patients who have been treated unsuccessfully with methotrexate: a six-month, double-blind, randomized, dose-ranging study.

Furst DE, Saag K, Fleischmann MR, Sherrer Y, Block JA, Schnitzer T, Rutstein J, Baldassare A, Kaine J, Calabrese L, Dietz F, Sack M, Senter RG, Wiesenhutter C, Schiff M, Stein CM, Satoi Y, Matsumoto A, Caldwell J, Harris RE, Moreland LW, Hurd E, Yocum D, Stamler DA.

Arthritis Rheum. 2002 Aug;46(8):2020-8.PMID: 12209503 [PubMed - indexed for MEDLINE]Related articlesFree article

Folic acid and cyanocobalamin levels in serum and erythrocytes during low-dose methotrexate therapy of rheumatoid arthritis and psoriatic arthritis patients.

Leeb BF, Witzmann G, Ogris E, Studnicka-Benke A, Andel I, Schweitzer H, Smolen JS.

Clin Exp Rheumatol. 1995 Jul-Aug;13(4):459-63.PMID: 7586777 [PubMed - indexed for MEDLINE]Related articles

Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: a systematic review.

Prey S, Paul C.

Br J Dermatol. 2009 Mar;160(3):622-8. Epub 2008 Oct 20. Review.PMID: 18945303 [PubMed - indexed for MEDLINE]Related articles

Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial. MIRA Trial Group.

Tilley BC, Alarcón GS, Heyse SP, Trentham DE, Neuner R, Kaplan DA, Clegg DO, Leisen JC, Buckley L, Cooper SM, Duncan H, Pillemer SR, Tuttleman M, Fowler SE.

Ann Intern Med. 1995 Jan 15;122(2):81-9.PMID: 7993000 [PubMed - indexed for MEDLINE]Related articlesFree article