PubMed

Low doses of interferon-alpha are as effective as higher doses in inducing remissions and prolonging survival in chronic myeloid leukemia.

Schofield JR, Robinson WA, Murphy JR, Rovira DK.

Ann Intern Med. 1994 Nov 15;121(10):736-44.PMID: 7944050 [PubMed - indexed for MEDLINE]Related articlesFree article

Prolonged subcutaneous administration of recombinant alpha 2b interferon in patients with previously untreated Philadelphia chromosome-positive chronic-phase chronic myelogenous leukemia: effect on remission duration and survival: Cancer and Leukemia Group B study 8583.

Ozer H, George SL, Schiffer CA, Rao K, Rao PN, Wurster-Hill DH, Arthur DD, Powell B, Gottlieb A, Peterson BA, Rai K, Testa JR, LeBeau M, Tantravahi R, Bloomfield CD.

Blood. 1993 Nov 15;82(10):2975-84.PMID: 8219189 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of Philadelphia chromosome-positive early chronic phase chronic myelogenous leukemia with daily doses of interferon alpha and low-dose cytarabine.

Kantarjian HM, O'Brien S, Smith TL, Rios MB, Cortes J, Beran M, Koller C, Giles FJ, Andreeff M, Kornblau S, Giralt S, Keating MJ, Talpaz M.

J Clin Oncol. 1999 Jan;17(1):284-92.PMID: 10458244 [PubMed - indexed for MEDLINE]Related articles

Prolonged survival in chronic myelogenous leukemia after cytogenetic response to interferon-alpha therapy. The Leukemia Service.

Kantarjian HM, Smith TL, O'Brien S, Beran M, Pierce S, Talpaz M.

Ann Intern Med. 1995 Feb 15;122(4):254-61.PMID: 7825760 [PubMed - indexed for MEDLINE]Related articlesFree article

Simultaneous homoharringtonine and interferon-alpha in the treatment of patients with chronic-phase chronic myelogenous leukemia.

O'Brien S, Talpaz M, Cortes J, Shan J, Giles FJ, Faderl S, Thomas D, Garcia-Manero G, Mallard S, Beth M, Koller C, Kornblau S, Andreeff M, Murgo A, Keating M, Kantarjian HM.

Cancer. 2002 Apr 1;94(7):2024-32.PMID: 11932905 [PubMed - indexed for MEDLINE]Related articlesFree article

Stage, percentage of basophils at diagnosis, hematologic response within six months, cytogenetic response in the first year: the main prognostic variables affecting outcome in patients with chronic myeloid leukemia in chronic phase treated with interferon-alpha. Results of the CML89 trial of the Spanish Collaborative Group on interferon-alpha2a and CML.

Steegmann JL, Odriozola J, Rodriguez-Salvanés F, Giraldo P, García-Laraña J, Ferro MT, Benítez E, Pérez-Pons C, Giralt M, Escribano L, Lavilla E, Miguel A, Areal C, Pérez-Encinas M, Abad A, Maldonado J, Massagué I, Fernández-Rañada JM.

Haematologica. 1999 Nov;84(11):978-87.PMID: 10553157 [PubMed - indexed for MEDLINE]Related articlesFree article

Response at three months is a good predictive factor for newly diagnosed chronic myeloid leukemia patients treated by recombinant interferon-alpha.

Mahon FX, Fabères C, Pueyo S, Cony-Makhoul P, Salmi R, Boiron JM, Marit G, Bilhou-Nabera C, Carrère A, Montastruc M, Pigneux A, Bernard P, Reiffers J.

Blood. 1998 Dec 1;92(11):4059-65.PMID: 9834210 [PubMed - indexed for MEDLINE]Related articlesFree article

Alpha-interferon with very-low-dose donor lymphocyte infusion for hematologic or cytogenetic relapse of chronic myeloid leukemia induces rapid and durable complete remissions and is associated with acceptable graft-versus-host disease.

Posthuma EF, Marijt EW, Barge RM, van Soest RA, Baas IO, Starrenburg CW, van Zelderen-Bhola SL, Fibbe WE, Smit WM, Willemze R, Falkenburg JH.

Biol Blood Marrow Transplant. 2004 Mar;10(3):204-12.PMID: 14993886 [PubMed - indexed for MEDLINE]Related articles

Results of therapy with interferon alpha and cyclic combination chemotherapy in patients with philadelphia chromosome positive chronic myelogenous leukemia in early chronic phase.

Giles FJ, Kantarjian H, O'Brien S, Rios MB, Cortes J, Beran M, Koller C, Keating M, Talpaz M.

Leuk Lymphoma. 2001 Apr;41(3-4):309-19.PMID: 11378543 [PubMed - indexed for MEDLINE]Related articles

[Treatment of chronic myeloid leukemia using alpha-interferon and hydroxyurea. Study of 30 cases]

Nese M, de Bellis R, Urtiarte R, Di Landro J.

Sangre (Barc). 1994 Jun;39(3):183-6. Spanish. PMID: 7940047 [PubMed - indexed for MEDLINE]Related articles

Interferon-alpha produces sustained cytogenetic responses in chronic myelogenous leukemia. Philadelphia chromosome-positive patients.

Talpaz M, Kantarjian H, Kurzrock R, Trujillo JM, Gutterman JU.

Ann Intern Med. 1991 Apr 1;114(7):532-8.PMID: 2001086 [PubMed - indexed for MEDLINE]Related articles

Imatinib mesylate for Philadelphia chromosome-positive, chronic-phase myeloid leukemia after failure of interferon-alpha: follow-up results.

Kantarjian HM, Talpaz M, O'Brien S, Smith TL, Giles FJ, Faderl S, Thomas DA, Garcia-Manero G, Issa JP, Andreeff M, Kornblau SM, Koller C, Beran M, Keating M, Rios MB, Shan J, Resta D, Capdeville R, Hayes K, Albitar M, Freireich EJ, Cortes JE.

Clin Cancer Res. 2002 Jul;8(7):2177-87.PMID: 12114418 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-dose alpha-interferon treatment of chronic myeloid leukemia.

Sanchez A, Robinson WA, Cohn A, Gonzalez R, Adlakha A.

Am J Hematol. 1992 Jan;39(1):61-2.PMID: 1536141 [PubMed - indexed for MEDLINE]Related articles

A prospective study of alpha-interferon and autologous bone marrow transplantation in chronic myeloid leukemia. The Italian Co-operative Study Group on Chronic Myeloid Leukemia.

Meloni G, Russo D, Baccarani M, Testoni N, Martinelli G, Fanin R, Zuffa E, Rosti G, Alimena G, Saglio G, Mandelli F, Tura S.

Haematologica. 1999 Aug;84(8):707-15.PMID: 10457406 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term follow-Up of the italian trial of interferon-alpha versus conventional chemotherapy in chronic myeloid leukemia. The Italian Cooperative Study Group on Chronic Myeloid Leukemia.

[No authors listed]

Blood. 1998 Sep 1;92(5):1541-8.PMID: 9716581 [PubMed - indexed for MEDLINE]Related articlesFree article

Result of high-dose imatinib mesylate in patients with Philadelphia chromosome-positive chronic myeloid leukemia after failure of interferon-alpha.

Cortes J, Giles F, O'Brien S, Thomas D, Garcia-Manero G, Rios MB, Faderl S, Verstovsek S, Ferrajoli A, Freireich EJ, Talpaz M, Kantarjian H.

Blood. 2003 Jul 1;102(1):83-6. Epub 2003 Mar 13.PMID: 12637317 [PubMed - indexed for MEDLINE]Related articlesFree article

U.S. Food and Drug Administration Drug Approval Summary: conversion of imatinib mesylate (STI571; Gleevec) tablets from accelerated approval to full approval.

Cohen MH, Johnson JR, Pazdur R.

Clin Cancer Res. 2005 Jan 1;11(1):12-9.PMID: 15671523 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical investigation of human alpha interferon in chronic myelogenous leukemia.

Talpaz M, Kantarjian HM, McCredie KB, Keating MJ, Trujillo J, Gutterman J.

Blood. 1987 May;69(5):1280-8.PMID: 3471281 [PubMed - indexed for MEDLINE]Related articlesFree article

[Treatment with interferon alfa-2a in the chronic phase of Philadelphia-positive chronic myeloid leukemia]

Steegmann JL, Lavilla E, Somolinos N, Pérez-Sánchez M, Lamana M, Olmeda F, Cámara R, Arranz R, Ferro MT, Fernández-Rañada JM.

Sangre (Barc). 1992 Oct;37(5):375-81. Spanish. PMID: 1293778 [PubMed - indexed for MEDLINE]Related articles

Use of alpha-2a-interferon to treat cytogenetic relapse of chronic myeloid leukemia after marrow transplantation.

Higano CS, Chielens D, Raskind W, Bryant E, Flowers ME, Radich J, Clift R, Appelbaum F.

Blood. 1997 Oct 1;90(7):2549-54.PMID: 9326220 [PubMed - indexed for MEDLINE]Related articlesFree article