PubMed

Anti-neutrophil-elastase defenses of the lower respiratory tract in alpha 1-antitrypsin deficiency directly augmented with an aerosol of alpha 1-antitrypsin.

Hubbard RC, Brantly ML, Sellers SE, Mitchell ME, Crystal RG.

Ann Intern Med. 1989 Aug 1;111(3):206-12.PMID: 2787611 [PubMed - indexed for MEDLINE]Related articles

Recombinant DNA-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin deficiency.

Hubbard RC, McElvaney NG, Sellers SE, Healy JT, Czerski DB, Crystal RG.

J Clin Invest. 1989 Oct;84(4):1349-54.PMID: 2794066 [PubMed - indexed for MEDLINE]Related articlesFree article

Strategies for aerosol therapy of alpha 1-antitrypsin deficiency by the aerosol route.

Hubbard RC, Crystal RG.

Lung. 1990;168 Suppl:565-78.PMID: 2117165 [PubMed - indexed for MEDLINE]Related articles

Replacement therapy for alpha 1-antitrypsin deficiency associated with emphysema.

Wewers MD, Casolaro MA, Sellers SE, Swayze SC, McPhaul KM, Wittes JT, Crystal RG.

N Engl J Med. 1987 Apr 23;316(17):1055-62.PMID: 3494198 [PubMed - indexed for MEDLINE]Related articles

Alpha-1-antitrypsin augmentation therapy for alpha-1-antitrypsin deficiency.

Hubbard RC, Crystal RG.

Am J Med. 1988 Jun 24;84(6A):52-62. Review.PMID: 3289387 [PubMed - indexed for MEDLINE]Related articles

Fate of aerosolized recombinant DNA-produced alpha 1-antitrypsin: use of the epithelial surface of the lower respiratory tract to administer proteins of therapeutic importance.

Hubbard RC, Casolaro MA, Mitchell M, Sellers SE, Arabia F, Matthay MA, Crystal RG.

Proc Natl Acad Sci U S A. 1989 Jan;86(2):680-4.PMID: 2783491 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of the S-type of alpha-1-antitrypsin as an in vivo and in vitro inhibitor of neutrophil elastase.

Ogushi F, Hubbard RC, Fells GA, Casolaro MA, Curiel DT, Brantly ML, Crystal RG.

Am Rev Respir Dis. 1988 Feb;137(2):364-70.PMID: 3257660 [PubMed - indexed for MEDLINE]Related articles

Pulmonary deposition and clearance of aerosolized alpha-1-proteinase inhibitor administered to dogs and to sheep.

Smith RM, Traber LD, Traber DL, Spragg RG.

J Clin Invest. 1989 Oct;84(4):1145-54.PMID: 2794051 [PubMed - indexed for MEDLINE]Related articlesFree article

Biochemical efficacy and safety of monthly augmentation therapy for alpha 1-antitrypsin deficiency.

Hubbard RC, Sellers S, Czerski D, Stephens L, Crystal RG.

JAMA. 1988 Sep 2;260(9):1259-64.PMID: 3261353 [PubMed - indexed for MEDLINE]Related articles

Augmentation therapy of alpha 1-antitrypsin deficiency.

Hubbard RC, Crystal RG.

Eur Respir J Suppl. 1990 Mar;9:44s-52s.PMID: 2340051 [PubMed - indexed for MEDLINE]Related articles

Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase.

Ogushi F, Fells GA, Hubbard RC, Straus SD, Crystal RG.

J Clin Invest. 1987 Nov;80(5):1366-74.PMID: 3500183 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of alpha-1-antitrypsin levels and antineutrophil elastase capacity of blood and lung in a patient with the alpha-1-antitrypsin phenotype null-null before and during alpha-1-antitrypsin augmentation therapy.

Wewers MD, Casolaro MA, Crystal RG.

Am Rev Respir Dis. 1987 Mar;135(3):539-43.PMID: 3493719 [PubMed - indexed for MEDLINE]Related articles

Aerosol alpha 1-antitrypsin treatment for cystic fibrosis.

McElvaney NG, Hubbard RC, Birrer P, Chernick MS, Caplan DB, Frank MM, Crystal RG.

Lancet. 1991 Feb 16;337(8738):392-4.PMID: 1671425 [PubMed - indexed for MEDLINE]Related articles

Risk factors for emphysema. Cigarette smoking is associated with a reduction in the association rate constant of lung alpha 1-antitrypsin for neutrophil elastase.

Ogushi F, Hubbard RC, Vogelmeier C, Fells GA, Crystal RG.

J Clin Invest. 1991 Mar;87(3):1060-5.PMID: 1999486 [PubMed - indexed for MEDLINE]Related articlesFree article

Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages.

Hubbard RC, Fells G, Gadek J, Pacholok S, Humes J, Crystal RG.

J Clin Invest. 1991 Sep;88(3):891-7.PMID: 1653278 [PubMed - indexed for MEDLINE]Related articlesFree article

Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema.

Gadek JE, Fells GA, Zimmerman RL, Rennard SI, Crystal RG.

J Clin Invest. 1981 Oct;68(4):889-98.PMID: 6169740 [PubMed - indexed for MEDLINE]Related articlesFree article

Aerosolization of recombinant SLPI to augment antineutrophil elastase protection of pulmonary epithelium.

Vogelmeier C, Buhl R, Hoyt RF, Wilson E, Fells GA, Hubbard RC, Schnebli HP, Thompson RC, Crystal RG.

J Appl Physiol. 1990 Nov;69(5):1843-8.PMID: 2272977 [PubMed - indexed for MEDLINE]Related articles

Recombinant secretory leukoprotease inhibitor augments glutathione levels in lung epithelial lining fluid.

Gillissen A, Birrer P, McElvaney NG, Buhl R, Vogelmeier C, Hoyt RF Jr, Hubbard RC, Crystal RG.

J Appl Physiol. 1993 Aug;75(2):825-32.PMID: 7901193 [PubMed - indexed for MEDLINE]Related articles

The pallid mouse. A model of genetic alpha 1-antitrypsin deficiency.

Martorana PA, Brand T, Gardi C, van Even P, de Santi MM, Calzoni P, Marcolongo P, Lungarella G.

Lab Invest. 1993 Feb;68(2):233-41.PMID: 8441253 [PubMed - indexed for MEDLINE]Related articles

Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase.

Hubbard RC, Ogushi F, Fells GA, Cantin AM, Jallat S, Courtney M, Crystal RG.

J Clin Invest. 1987 Nov;80(5):1289-95.PMID: 2824559 [PubMed - indexed for MEDLINE]Related articlesFree article