PubMed

Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells.

González-Pérez V, Reiner DJ, Alan JK, Mitchell C, Edwards LJ, Khazak V, Der CJ, Cox AD.

J Mol Signal. 2010 Feb 23;5:2.PMID: 20178605 [PubMed - in process]Free PMC ArticleFree textRelated citations

MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events.

Wu Y, Han M, Guan KL.

Genes Dev. 1995 Mar 15;9(6):742-55.PMID: 7729690 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.

Kato-Stankiewicz J, Hakimi I, Zhi G, Zhang J, Serebriiskii I, Guo L, Edamatsu H, Koide H, Menon S, Eckl R, Sakamuri S, Lu Y, Chen QZ, Agarwal S, Baumbach WR, Golemis EA, Tamanoi F, Khazak V.

Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14398-403. Epub 2002 Oct 21.PMID: 12391290 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1.

Kogut MH, Genovese KJ, He H.

Mol Immunol. 2007 Mar;44(7):1729-36. Epub 2006 Oct 12.PMID: 17045653 [PubMed - indexed for MEDLINE]Related citations

Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates.

Hsu V, Zobel CL, Lambie EJ, Schedl T, Kornfeld K.

Genetics. 2002 Feb;160(2):481-92.PMID: 11861555 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Activation of Ras and the mitogen-activated protein kinase pathway promotes protein degradation in muscle cells of Caenorhabditis elegans.

Szewczyk NJ, Peterson BK, Jacobson LA.

Mol Cell Biol. 2002 Jun;22(12):4181-8.PMID: 12024031 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway.

Geppert TD, Whitehurst CE, Thompson P, Beutler B.

Mol Med. 1994 Nov;1(1):93-103.PMID: 8790605 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Use of Caenorhabditis elegans to evaluate inhibitors of Ras function in vivo.

Reiner DJ, González-Pérez V, Der CJ, Cox AD.

Methods Enzymol. 2008;439:425-49.PMID: 18374181 [PubMed - indexed for MEDLINE]Related citations

Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2.

Wen-Sheng W.

Cancer Lett. 2006 Jul 28;239(1):27-35. Epub 2005 Sep 19.PMID: 16169661 [PubMed - indexed for MEDLINE]Related citations

Pathway crosstalk between Ras/Raf and PI3K in promotion of M-CSF-induced MEK/ERK-mediated osteoclast survival.

Bradley EW, Ruan MM, Vrable A, Oursler MJ.

J Cell Biochem. 2008 Jul 1;104(4):1439-51.PMID: 18275061 [PubMed - indexed for MEDLINE]Related citations

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance.

McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Wong EW, Chang F, Lehmann B, Terrian DM, Milella M, Tafuri A, Stivala F, Libra M, Basecke J, Evangelisti C, Martelli AM, Franklin RA.

Biochim Biophys Acta. 2007 Aug;1773(8):1263-84. Epub 2006 Oct 7. Review.PMID: 17126425 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Identification of residues and domains of Raf important for function in vivo and in vitro.

Harding A, Hsu V, Kornfeld K, Hancock JF.

J Biol Chem. 2003 Nov 14;278(46):45519-27. Epub 2003 Sep 3.PMID: 12954633 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Yeast screens for inhibitors of Ras-Raf interaction and characterization of MCP inhibitors of Ras-Raf interaction.

Khazak V, Kato-Stankiewicz J, Tamanoi F, Golemis EA.

Methods Enzymol. 2006;407:612-29.PMID: 16757356 [PubMed - indexed for MEDLINE]Related citations

A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans.

Rocheleau CE, Howard RM, Goldman AP, Volk ML, Girard LJ, Sundaram MV.

Genetics. 2002 May;161(1):121-31.PMID: 12019228 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling.

Rocheleau CE, Rönnlund A, Tuck S, Sundaram MV.

Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11757-62. Epub 2005 Aug 5.PMID: 16085714 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Functional interactions of Raf and MEK with Jun-N-terminal kinase (JNK) result in a positive feedback loop on the oncogenic Ras signaling pathway.

Adler V, Qu Y, Smith SJ, Izotova L, Pestka S, Kung HF, Lin M, Friedman FK, Chie L, Chung D, Boutjdir M, Pincus MR.

Biochemistry. 2005 Aug 16;44(32):10784-95.PMID: 16086581 [PubMed - indexed for MEDLINE]Related citations

Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration.

Giehl K, Skripczynski B, Mansard A, Menke A, Gierschik P.

Oncogene. 2000 Jun 8;19(25):2930-42.PMID: 10871844 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway.

Paumelle R, Tulasne D, Kherrouche Z, Plaza S, Leroy C, Reveneau S, Vandenbunder B, Fafeur V.

Oncogene. 2002 Apr 4;21(15):2309-19. Erratum in: Oncogene 2002 Jul 18;21(31):4872. Tulashe, David [corrected to Tulasne, David]; Reveneau, Syline [corrected to Reveneau, Sylvie]. PMID: 11948414 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Radicicol suppresses transformation and restores tropomyosin-2 expression in both ras- and MEK-transformed cells without inhibiting the Raf/MEK/ERK signaling cascade.

Kim PN, Jonasch E, Mosterman BC, Mier JW, Janssen RA.

Cell Growth Differ. 2001 Nov;12(11):543-50.PMID: 11714635 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration.

Rajalingam K, Wunder C, Brinkmann V, Churin Y, Hekman M, Sievers C, Rapp UR, Rudel T.

Nat Cell Biol. 2005 Aug;7(8):837-43. Epub 2005 Jul 24.PMID: 16041367 [PubMed - indexed for MEDLINE]Free ArticleRelated citations