PubMed

Topical recombinant thrombin at a concentration of 1000 IU/mL reliably shortens in vivo TTH and delivers durable hemostasis in the presence of heparin anticoagulation and clopidogrel platelet inhibition in a rabbit model of vascular bleeding.

Hughes SD, Bishop PD, Garcia R, Zhang T, Alexander WA.

Ann Surg Innov Res. 2009 Nov 19;3:14.PMID: 19925675 [PubMed]Free PMC ArticleFree textRelated citations

A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.

Weaver FA, Lew W, Granke K, Yonehiro L, Delange B, Alexander WA; Study Investigators.

J Vasc Surg. 2008 Jun;47(6):1266-73. Epub 2008 Apr 28.PMID: 18440754 [PubMed - indexed for MEDLINE]Related citations

A phase 3b, open-label, single-group immunogenicity and safety study of topical recombinant thrombin in surgical hemostasis.

Singla NK, Ballard JL, Moneta G, Randleman CD Jr, Renkens KL, Alexander WA.

J Am Coll Surg. 2009 Jul;209(1):68-74. Epub 2009 May 28.PMID: 19651065 [PubMed - indexed for MEDLINE]Related citations

Safety and immunogenicity observations pooled from eight clinical trials of recombinant human thrombin.

Ballard JL, Weaver FA, Singla NK, Chapman WC, Alexander WA.

J Am Coll Surg. 2010 Feb;210(2):199-204. Epub 2009 Dec 14.PMID: 20113940 [PubMed - indexed for MEDLINE]Related citations

Effects of plasma dilution on tissue-factor-induced thrombin generation and thromboelastography: partly compensating role of platelets.

Schols SE, Feijge MA, Lancé MD, Hamulyák K, ten Cate H, Heemskerk JW, van Pampus EC.

Transfusion. 2008 Nov;48(11):2384-94. Epub 2008 Jul 23.PMID: 18673348 [PubMed - indexed for MEDLINE]Related citations

Differential effects of direct thrombin inhibitors and antithrombin-dependent anticoagulants on the dynamics of clot formation.

Young G, Yonekawa KE, Nakagawa PA, Blain RC, Lovejoy AE, Nugent DJ.

Blood Coagul Fibrinolysis. 2007 Mar;18(2):97-103.PMID: 17287624 [PubMed - indexed for MEDLINE]Related citations

The effect of chitosan (poly-N-acetyl glucosamine) on lingual hemostasis in heparinized rabbits.

Klokkevold PR, Fukayama H, Sung EC, Bertolami CN.

J Oral Maxillofac Surg. 1999 Jan;57(1):49-52.PMID: 9915395 [PubMed - indexed for MEDLINE]Related citations

In-vitro evaluation of anti-factor IXa aptamer on thrombin generation, clotting time, and viscoelastometry.

Tanaka KA, Szlam F, Rusconi CP, Levy JH.

Thromb Haemost. 2009 May;101(5):827-33.PMID: 19404534 [PubMed - indexed for MEDLINE]Related citations

Development of an animal model for assessment of the hemostatic efficacy of fibrin sealant in vascular surgery.

Kheirabadi BS, Pearson R, Rudnicka K, Somwaru L, MacPhee M, Drohan W, Tuthill D.

J Surg Res. 2001 Sep;100(1):84-92.PMID: 11516209 [PubMed - indexed for MEDLINE]Related citations

Recombinant thrombin: safety and immunogenicity in burn wound excision and grafting.

Greenhalgh DG, Gamelli RL, Collins J, Sood R, Mozingo DW, Gray TE, Alexander WA.

J Burn Care Res. 2009 May-Jun;30(3):371-9.PMID: 19349898 [PubMed - indexed for MEDLINE]Related citations

Thrombin generation assay and viscoelastic coagulation monitors demonstrate differences in the mode of thrombin inhibition between unfractionated heparin and bivalirudin.

Tanaka KA, Szlam F, Sun HY, Taketomi T, Levy JH.

Anesth Analg. 2007 Oct;105(4):933-9, table of contents.PMID: 17898368 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

The effects of vasoactive agents, platelet agonists and anticoagulation on thrombelastography.

Kawasaki J, Katori N, Taketomi T, Terui K, Tanaka KA.

Acta Anaesthesiol Scand. 2007 Oct;51(9):1237-44.PMID: 17850565 [PubMed - indexed for MEDLINE]Related citations

The effects of protamine overdose on coagulation parameters as measured by the thrombelastograph.

Khan NU, Wayne CK, Barker J, Strang T.

Eur J Anaesthesiol. 2010 Jul;27(7):624-7.PMID: 20485179 [PubMed - in process]Related citations

Assessment of the resonance thromboelastograph CS-3 for differentiation of coagulation disorders: a pilot in vitro investigation of simulated post-cardiopulmonary bypass coagulopathies.

Koster A, Hansen R, Schulz J, Kukucka M, Fischer T, Kuppe H.

J Extra Corpor Technol. 2001 Sep;33(3):159-66.PMID: 11680729 [PubMed - indexed for MEDLINE]Related citations

Hydroxyethyl starch enhances argatroban-mediated decreases in clot propagation and strength by diminishing thrombin-fibrinogen interactions.

Nielsen VG, Kirklin JK.

Blood Coagul Fibrinolysis. 2007 Jan;18(1):49-54.PMID: 17179827 [PubMed - indexed for MEDLINE]Related citations

Topical haemostatics in renal trauma--an evaluation of four different substances in an experimental setting.

Björses K, Holst J.

J Trauma. 2009 Mar;66(3):602-11.PMID: 19276727 [PubMed - indexed for MEDLINE]Related citations

Assessment of topical hemostats in a renal hemorrhage model in heparinized rats.

Tuthill DD, Bayer V, Gallagher AM, Drohan WN, MacPhee MJ.

J Surg Res. 2001 Feb;95(2):126-32.PMID: 11162035 [PubMed - indexed for MEDLINE]Related citations

The effects of fibrinogen levels on thromboelastometric variables in the presence of thrombocytopenia.

Lang T, Johanning K, Metzler H, Piepenbrock S, Solomon C, Rahe-Meyer N, Tanaka KA.

Anesth Analg. 2009 Mar;108(3):751-8.PMID: 19224779 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

The importance of factor XIII as a component of fibrin sealants.

Dickneite G, Metzner HJ, Kroez M, Hein B, Nicolay U.

J Surg Res. 2002 Oct;107(2):186-95.PMID: 12429174 [PubMed - indexed for MEDLINE]Related citations

Thrombelastograph (TEG) analysis of platelet gel formed with different thrombin concentrations.

Ellis WC, Cassidy LK, Finney AS, Spiwak AJ, Riley JB.

J Extra Corpor Technol. 2005 Mar;37(1):52-7.PMID: 15804158 [PubMed - indexed for MEDLINE]Related citations