PubMed

Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis.

Csaki C, Mobasheri A, Shakibaei M.

Arthritis Res Ther. 2009;11(6):R165. Epub 2009 Nov 4.PMID: 19889203 [PubMed - in process]Related articles

Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis.

Shakibaei M, Csaki C, Nebrich S, Mobasheri A.

Biochem Pharmacol. 2008 Dec 1;76(11):1426-39. Epub 2008 Jun 3.PMID: 18606398 [PubMed - indexed for MEDLINE]Related articles

Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis.

Shakibaei M, John T, Schulze-Tanzil G, Lehmann I, Mobasheri A.

Biochem Pharmacol. 2007 May 1;73(9):1434-45. Epub 2007 Jan 7.PMID: 17291458 [PubMed - indexed for MEDLINE]Related articles

Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes.

Gonzales AM, Orlando RA.

Nutr Metab (Lond). 2008 Jun 12;5:17.PMID: 18549505 [PubMed - in process]Related articlesFree article

Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes.

Schulze-Tanzil G, Mobasheri A, Sendzik J, John T, Shakibaei M.

Ann N Y Acad Sci. 2004 Dec;1030:578-86.PMID: 15659840 [PubMed - indexed for MEDLINE]Related articles

Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation.

Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB.

Mol Pharmacol. 2006 Jan;69(1):195-206. Epub 2005 Oct 11.PMID: 16219905 [PubMed - indexed for MEDLINE]Related articlesFree article

Punica granatum L. extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro.

Ahmed S, Wang N, Hafeez BB, Cheruvu VK, Haqqi TM.

J Nutr. 2005 Sep;135(9):2096-102.PMID: 16140882 [PubMed - indexed for MEDLINE]Related articlesFree article

Epigallocatechin-3-gallate inhibits interleukin-1beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB.

Singh R, Ahmed S, Islam N, Goldberg VM, Haqqi TM.

Arthritis Rheum. 2002 Aug;46(8):2079-86.PMID: 12209512 [PubMed - indexed for MEDLINE]Related articlesFree article

Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: an immunomorphological study.

Shakibaei M, Schulze-Tanzil G, John T, Mobasheri A.

Ann Anat. 2005 Nov;187(5-6):487-97.PMID: 16320828 [PubMed - indexed for MEDLINE]Related articles

Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation.

Manna SK, Mukhopadhyay A, Aggarwal BB.

J Immunol. 2000 Jun 15;164(12):6509-19.PMID: 10843709 [PubMed - indexed for MEDLINE]Related articlesFree article

RelA is required for IL-1beta stimulation of Matrix Metalloproteinase-1 expression in chondrocytes.

Raymond L, Eck S, Hays E, Tomek I, Kantor S, Vincenti M.

Osteoarthritis Cartilage. 2007 Apr;15(4):431-41. Epub 2006 Nov 13.PMID: 17097317 [PubMed - indexed for MEDLINE]Related articlesFree article

Chondroprotective effects of glucosamine involving the p38 MAPK and Akt signaling pathways.

Lin YC, Liang YC, Sheu MT, Lin YC, Hsieh MS, Chen TF, Chen CH.

Rheumatol Int. 2008 Aug;28(10):1009-16. Epub 2008 Mar 14.PMID: 18340449 [PubMed - indexed for MEDLINE]Related articles

Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study.

Boileau C, Amiable N, Martel-Pelletier J, Fahmi H, Duval N, Pelletier JP.

Arthritis Res Ther. 2007;9(6):R121.PMID: 18031579 [PubMed - indexed for MEDLINE]Related articlesFree article

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.

Sandur SK, Ichikawa H, Sethi G, Ahn KS, Aggarwal BB.

J Biol Chem. 2006 Jun 23;281(25):17023-33. Epub 2006 Apr 19.PMID: 16624823 [PubMed - indexed for MEDLINE]Related articlesFree article

A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells.

Shishodia S, Sethi G, Konopleva M, Andreeff M, Aggarwal BB.

Clin Cancer Res. 2006 Mar 15;12(6):1828-38.PMID: 16551868 [PubMed - indexed for MEDLINE]Related articlesFree article

Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation.

Sung B, Pandey MK, Aggarwal BB.

Mol Pharmacol. 2007 Jun;71(6):1703-14. Epub 2007 Mar 26.PMID: 17387141 [PubMed - indexed for MEDLINE]Related articlesFree article

Pinitol targets nuclear factor-kappaB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis.

Sethi G, Ahn KS, Sung B, Aggarwal BB.

Mol Cancer Ther. 2008 Jun;7(6):1604-14.PMID: 18566231 [PubMed - indexed for MEDLINE]Related articlesFree article

NF-kappaBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-alpha-induced chondrocytes.

Lianxu C, Hongti J, Changlong Y.

Osteoarthritis Cartilage. 2006 Apr;14(4):367-76. Epub 2005 Dec 22.PMID: 16376111 [PubMed - indexed for MEDLINE]Related articles

Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.

Shishodia S, Potdar P, Gairola CG, Aggarwal BB.

Carcinogenesis. 2003 Jul;24(7):1269-79. Epub 2003 May 9.PMID: 12807725 [PubMed - indexed for MEDLINE]Related articlesFree article

Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice.

Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE, Price JE.

Clin Cancer Res. 2005 Oct 15;11(20):7490-8.PMID: 16243823 [PubMed - indexed for MEDLINE]Related articlesFree article