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    Results: 1 to 20 of 156

    1.

    PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro.

    Finn RS, Dering J, Conklin D, Kalous O, Cohen DJ, Desai AJ, Ginther C, Atefi M, Chen I, Fowst C, Los G, Slamon DJ.

    Breast Cancer Res. 2009;11(5):R77.

    PMID:
    19874578
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    2.

    CDK inhibitors as potential breast cancer therapeutics: new evidence for enhanced efficacy in ER+ disease.

    Sutherland RL, Musgrove EA.

    Breast Cancer Res. 2009;11(6):112. Epub 2009 Dec 7.

    PMID:
    20067604
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    3.

    A new indole-3-carbinol tetrameric derivative inhibits cyclin-dependent kinase 6 expression, and induces G1 cell cycle arrest in both estrogen-dependent and estrogen-independent breast cancer cell lines.

    Brandi G, Paiardini M, Cervasi B, Fiorucci C, Filippone P, De Marco C, Zaffaroni N, Magnani M.

    Cancer Res. 2003 Jul 15;63(14):4028-36.

    PMID:
    12874002
    [PubMed - indexed for MEDLINE]
    Free Article

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    4.

    Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer.

    Konecny GE, Winterhoff B, Kolarova T, Qi J, Manivong K, Dering J, Yang G, Chalukya M, Wang HJ, Anderson L, Kalli KR, Finn RS, Ginther C, Jones S, Velculescu VE, Riehle D, Cliby WA, Randolph S, Koehler M, Hartmann LC, Slamon DJ.

    Clin Cancer Res. 2011 Mar 15;17(6):1591-602. Epub 2011 Jan 28.

    PMID:
    21278246
    [PubMed - indexed for MEDLINE]

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    5.

    Cell cycle and biochemical effects of PD 0183812. A potent inhibitor of the cyclin D-dependent kinases CDK4 and CDK6.

    Fry DW, Bedford DC, Harvey PH, Fritsch A, Keller PR, Wu Z, Dobrusin E, Leopold WR, Fattaey A, Garrett MD.

    J Biol Chem. 2001 May 18;276(20):16617-23. Epub 2001 Feb 6.

    PMID:
    11278443
    [PubMed - indexed for MEDLINE]
    Free Article

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    6.

    Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells.

    Le XF, Arachchige-Don AS, Mao W, Horne MC, Bast RC Jr.

    Mol Cancer Ther. 2007 Nov;6(11):2843-57.

    PMID:
    18025271
    [PubMed - indexed for MEDLINE]
    Free Article

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    7.

    Multifaceted regulation of cell cycle progression by estrogen: regulation of Cdk inhibitors and Cdc25A independent of cyclin D1-Cdk4 function.

    Foster JS, Henley DC, Bukovsky A, Seth P, Wimalasena J.

    Mol Cell Biol. 2001 Feb;21(3):794-810.

    PMID:
    11154267
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    8.

    Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells.

    Cover CM, Hsieh SJ, Cram EJ, Hong C, Riby JE, Bjeldanes LF, Firestone GL.

    Cancer Res. 1999 Mar 15;59(6):1244-51.

    PMID:
    10096555
    [PubMed - indexed for MEDLINE]
    Free Article

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    9.

    Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure.

    Dean JL, Thangavel C, McClendon AK, Reed CA, Knudsen ES.

    Oncogene. 2010 Jul 15;29(28):4018-32. Epub 2010 May 17.

    PMID:
    20473330
    [PubMed - indexed for MEDLINE]

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    10.

    Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling.

    Cover CM, Hsieh SJ, Tran SH, Hallden G, Kim GS, Bjeldanes LF, Firestone GL.

    J Biol Chem. 1998 Feb 13;273(7):3838-47.

    PMID:
    9461564
    [PubMed - indexed for MEDLINE]
    Free Article

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    11.

    Insulin-like growth factor binding protein-3 induces G1 cell cycle arrest with inhibition of cyclin-dependent kinase 2 and 4 in MCF-7 human breast cancer cells.

    Kim HS, Lee WJ, Lee SW, Chae HW, Kim DH, Oh Y.

    Horm Metab Res. 2010 Mar;42(3):165-72. Epub 2009 Dec 3.

    PMID:
    19960406
    [PubMed - indexed for MEDLINE]

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    12.

    Growth inhibition of human MDA-mB-231 breast cancer cells by delta-tocotrienol is associated with loss of cyclin D1/CDK4 expression and accompanying changes in the state of phosphorylation of the retinoblastoma tumor suppressor gene product.

    Elangovan S, Hsieh TC, Wu JM.

    Anticancer Res. 2008 Sep-Oct;28(5A):2641-7.

    PMID:
    19035289
    [PubMed - indexed for MEDLINE]

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    13.

    Anti-HER2 antibody trastuzumab inhibits CDK2-mediated NPAT and histone H4 expression via the PI3K pathway.

    Le XF, Bedrosian I, Mao W, Murray M, Lu Z, Keyomarsi K, Lee MH, Zhao J, Bast RC Jr.

    Cell Cycle. 2006 Aug;5(15):1654-61. Epub 2006 Aug 1.

    PMID:
    16861913
    [PubMed - indexed for MEDLINE]
    Free Article

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    14.

    Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells.

    Rivadeneira DB, Mayhew CN, Thangavel C, Sotillo E, Reed CA, Graña X, Knudsen ES.

    Gastroenterology. 2010 May;138(5):1920-30. Epub 2010 Jan 25.

    PMID:
    20100483
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    15.

    Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer.

    Thangavel C, Dean JL, Ertel A, Knudsen KE, Aldaz CM, Witkiewicz AK, Clarke R, Knudsen ES.

    Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. Print 2011 Jun.

    PMID:
    21367843
    [PubMed - indexed for MEDLINE]

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    16.

    Pharmacologic inhibition of cyclin-dependent kinase 4/6 activity arrests proliferation in myoblasts and rhabdomyosarcoma-derived cells.

    Saab R, Bills JL, Miceli AP, Anderson CM, Khoury JD, Fry DW, Navid F, Houghton PJ, Skapek SX.

    Mol Cancer Ther. 2006 May;5(5):1299-308.

    PMID:
    16731763
    [PubMed - indexed for MEDLINE]
    Free Article

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    17.

    Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells.

    Zavodovskaya M, Campbell MJ, Maddux BA, Shiry L, Allan G, Hodges L, Kushner P, Kerner JA, Youngren JF, Goldfine ID.

    J Cell Biochem. 2008 Feb 1;103(2):624-35.

    PMID:
    17562544
    [PubMed - indexed for MEDLINE]

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    18.

    Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene.

    Menendez JA, Vellon L, Lupu R.

    Ann Oncol. 2005 Aug;16(8):1253-67. Epub 2005 May 3.

    PMID:
    15870086
    [PubMed - indexed for MEDLINE]
    Free Article

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    19.

    Interaction between Polyamines and the Mitogen-Activated Protein Kinase Pathway in the Regulation of Cell Cycle Variables in Breast Cancer Cells.

    Hu X, Washington S, Verderame MF, Manni A.

    Cancer Res. 2005 Dec 1;65(23):11026-33.

    PMID:
    16322252
    [PubMed - indexed for MEDLINE]
    Free Article

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    20.

    Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells.

    Konecny GE, Pegram MD, Venkatesan N, Finn R, Yang G, Rahmeh M, Untch M, Rusnak DW, Spehar G, Mullin RJ, Keith BR, Gilmer TM, Berger M, Podratz KC, Slamon DJ.

    Cancer Res. 2006 Feb 1;66(3):1630-9.

    PMID:
    16452222
    [PubMed - indexed for MEDLINE]
    Free Article

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