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    Results: 1 to 20 of 94

    1.

    CD74 interacts with APP and suppresses the production of Abeta.

    Matsuda S, Matsuda Y, D'Adamio L.

    Mol Neurodegener. 2009 Oct 22;4:41.

    PMID:
    19849849
    [PubMed - in process]
    Free PMC Article
    2.

    BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.

    Matsuda S, Matsuda Y, D'Adamio L.

    J Biol Chem. 2009 Jun 5;284(23):15815-25. Epub 2009 Apr 14.

    PMID:
    19366692
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    3.

    Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease.

    Sambamurti K, Greig NH, Lahiri DK.

    Neuromolecular Med. 2002;1(1):1-31. Review.

    PMID:
    12025813
    [PubMed - indexed for MEDLINE]
    4.

    [Alzheimer disease: cellular and molecular aspects].

    Octave JN.

    Bull Mem Acad R Med Belg. 2005;160(10-12):445-9; discussion 450-1. French.

    PMID:
    16768248
    [PubMed - indexed for MEDLINE]
    5.

    GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.

    Wahle T, Thal DR, Sastre M, Rentmeister A, Bogdanovic N, Famulok M, Heneka MT, Walter J.

    J Neurosci. 2006 Dec 6;26(49):12838-46.

    PMID:
    17151287
    [PubMed - indexed for MEDLINE]
    Free Article
    6.

    The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.

    Wanngren J, Frånberg J, Svensson AI, Laudon H, Olsson F, Winblad B, Liu F, Näslund J, Lundkvist J, Karlström H.

    J Biol Chem. 2010 Mar 19;285(12):8527-36. Epub 2010 Jan 27.

    PMID:
    20106965
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    8.

    Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

    Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.

    J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. Epub 2009 Aug 11.

    PMID:
    19671883
    [PubMed - indexed for MEDLINE]
    Free Article
    9.

    RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.

    Désiré L, Bourdin J, Loiseau N, Peillon H, Picard V, De Oliveira C, Bachelot F, Leblond B, Taverne T, Beausoleil E, Lacombe S, Drouin D, Schweighoffer F.

    J Biol Chem. 2005 Nov 11;280(45):37516-25. Epub 2005 Sep 8.

    PMID:
    16150730
    [PubMed - indexed for MEDLINE]
    Free Article
    10.

    CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.

    Zhou S, Zhou H, Walian PJ, Jap BK.

    Proc Natl Acad Sci U S A. 2005 May 24;102(21):7499-504. Epub 2005 May 12.

    PMID:
    15890777
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    11.

    Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein.

    Nunan J, Williamson NA, Hill AF, Sernee MF, Masters CL, Small DH.

    J Neurosci Res. 2003 Nov 1;74(3):378-85.

    PMID:
    14598314
    [PubMed - indexed for MEDLINE]
    12.

    Cellular mechanisms of beta-amyloid production and secretion.

    Sinha S, Lieberburg I.

    Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11049-53. Review.

    PMID:
    10500121
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    13.

    The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production.

    Matsuda S, Giliberto L, Matsuda Y, Davies P, McGowan E, Pickford F, Ghiso J, Frangione B, D'Adamio L.

    J Biol Chem. 2005 Aug 12;280(32):28912-6. Epub 2005 Jun 27.

    PMID:
    15983050
    [PubMed - indexed for MEDLINE]
    Free Article
    14.

    RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation.

    Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE.

    J Biol Chem. 2007 Feb 16;282(7):4318-25. Epub 2006 Dec 14.

    PMID:
    17170108
    [PubMed - indexed for MEDLINE]
    Free Article
    15.

    Production and Functional Assays of Recombinant Secreted Amyloid Precursor Protein (APP) (sAPPα).

    Barger SW.

    Methods Mol Med. 2000;32:63-78.

    PMID:
    21318511
    [PubMed - in process]
    16.

    Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.

    Wu G, Sankaranarayanan S, Hsieh SH, Simon AJ, Savage MJ.

    J Neurosci Res. 2011 Jun;89(6):822-32. doi: 10.1002/jnr.22618. Epub 2011 Mar 23.

    PMID:
    21433051
    [PubMed - indexed for MEDLINE]
    17.

    Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production.

    Eggert S, Midthune B, Cottrell B, Koo EH.

    J Biol Chem. 2009 Oct 16;284(42):28943-52. Epub 2009 Jul 13.

    PMID:
    19596858
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    18.

    Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro.

    Mei Z, Zhang F, Tao L, Zheng W, Cao Y, Wang Z, Tang S, Le K, Chen S, Pi R, Liu P.

    Neurosci Lett. 2009 Mar 13;452(2):90-5. Epub 2009 Jan 13.

    PMID:
    19154776
    [PubMed - indexed for MEDLINE]
    19.

    Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo.

    Kim ML, Zhang B, Mills IP, Milla ME, Brunden KR, Lee VM.

    J Neurosci. 2008 Nov 12;28(46):12052-61.

    PMID:
    19005070
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    20.

    Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice.

    Cui H, Hung AC, Klaver DW, Suzuki T, Freeman C, Narkowicz C, Jacobson GA, Small DH.

    PLoS One. 2011;6(7):e23007. Epub 2011 Jul 29.

    PMID:
    21829577
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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