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    Results: 1 to 20 of 89

    1.

    Notch versus the proteasome: what is the target of gamma-secretase inhibitor-I?

    Clementz AG, Osipo C.

    Breast Cancer Res. 2009;11(5):110. Epub .

    PMID:
    19849815
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    2.

    The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition.

    Han J, Ma I, Hendzel MJ, Allalunis-Turner J.

    Breast Cancer Res. 2009;11(4):R57. Epub 2009 Aug 6.

    PMID:
    19660128
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    3.

    Synthetic lethality through combined Notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer.

    Dong Y, Li A, Wang J, Weber JD, Michel LS.

    Cancer Res. 2010 Jul 1;70(13):5465-74. Epub 2010 Jun 22.

    PMID:
    20570903
    [PubMed - indexed for MEDLINE]
    Free Article
    4.

    Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.

    Efferson CL, Winkelmann CT, Ware C, Sullivan T, Giampaoli S, Tammam J, Patel S, Mesiti G, Reilly JF, Gibson RE, Buser C, Yeatman T, Coppola D, Winter C, Clark EA, Draetta GF, Strack PR, Majumder PK.

    Cancer Res. 2010 Mar 15;70(6):2476-84. Epub 2010 Mar 2.

    PMID:
    20197467
    [PubMed - indexed for MEDLINE]
    Free Article
    5.

    Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design.

    Wei P, Walls M, Qiu M, Ding R, Denlinger RH, Wong A, Tsaparikos K, Jani JP, Hosea N, Sands M, Randolph S, Smeal T.

    Mol Cancer Ther. 2010 Jun;9(6):1618-28. Epub 2010 Jun 8.

    PMID:
    20530712
    [PubMed - indexed for MEDLINE]
    Free Article
    6.

    GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia.

    Meng X, Matlawska-Wasowska K, Girodon F, Mazel T, Willman CL, Atlas S, Chen IM, Harvey RC, Hunger SP, Ness SA, Winter SS, Wilson BS.

    Leukemia. 2011 Jul;25(7):1135-46. doi: 10.1038/leu.2011.50. Epub 2011 Apr 15.

    PMID:
    21494254
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    7.

    z-Leucinyl-leucinyl-norleucinal induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response.

    Monticone M, Biollo E, Fabiano A, Fabbi M, Daga A, Romeo F, Maffei M, Melotti A, Giaretti W, Corte G, Castagnola P.

    Mol Cancer Res. 2009 Nov;7(11):1822-34. Epub 2009 Oct 27.

    PMID:
    19861404
    [PubMed - indexed for MEDLINE]
    Free Article
    8.

    Notch signaling in breast cancer and tumor angiogenesis: cross-talk and therapeutic potentials.

    Shi W, Harris AL.

    J Mammary Gland Biol Neoplasia. 2006 Jan;11(1):41-52. Review.

    PMID:
    16947085
    [PubMed - indexed for MEDLINE]
    9.

    Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.

    Konishi J, Kawaguchi KS, Vo H, Haruki N, Gonzalez A, Carbone DP, Dang TP.

    Cancer Res. 2007 Sep 1;67(17):8051-7.

    PMID:
    17804716
    [PubMed - indexed for MEDLINE]
    Free Article
    10.

    Mechanisms and clinical prospects of Notch inhibitors in the therapy of hematological malignancies.

    Nefedova Y, Gabrilovich D.

    Drug Resist Updat. 2008 Dec;11(6):210-8. Epub 2008 Oct 31. Review.

    PMID:
    18951834
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    11.

    Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.

    Lewis HD, Leveridge M, Strack PR, Haldon CD, O'neil J, Kim H, Madin A, Hannam JC, Look AT, Kohl N, Draetta G, Harrison T, Kerby JA, Shearman MS, Beher D.

    Chem Biol. 2007 Feb;14(2):209-19.

    PMID:
    17317574
    [PubMed - indexed for MEDLINE]
    12.

    Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.

    Li T, Wen H, Brayton C, Das P, Smithson LA, Fauq A, Fan X, Crain BJ, Price DL, Golde TE, Eberhart CG, Wong PC.

    J Biol Chem. 2007 Nov 2;282(44):32264-73. Epub 2007 Sep 7.

    PMID:
    17827153
    [PubMed - indexed for MEDLINE]
    Free Article
    13.

    Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation.

    Tanaka M, Setoguchi T, Hirotsu M, Gao H, Sasaki H, Matsunoshita Y, Komiya S.

    Br J Cancer. 2009 Jun 16;100(12):1957-65. Epub 2009 May 19.

    PMID:
    19455146
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    14.

    Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties.

    Luistro L, He W, Smith M, Packman K, Vilenchik M, Carvajal D, Roberts J, Cai J, Berkofsky-Fessler W, Hilton H, Linn M, Flohr A, Jakob-Røtne R, Jacobsen H, Glenn K, Heimbrook D, Boylan JF.

    Cancer Res. 2009 Oct 1;69(19):7672-80. Epub 2009 Sep 22.

    PMID:
    19773430
    [PubMed - indexed for MEDLINE]
    Free Article
    15.

    Rational targeting of Notch signaling in cancer.

    Rizzo P, Osipo C, Foreman K, Golde T, Osborne B, Miele L.

    Oncogene. 2008 Sep 1;27(38):5124-31. Review.

    PMID:
    18758481
    [PubMed - indexed for MEDLINE]
    16.

    ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor.

    Osipo C, Patel P, Rizzo P, Clementz AG, Hao L, Golde TE, Miele L.

    Oncogene. 2008 Aug 28;27(37):5019-32. Epub 2008 May 12.

    PMID:
    18469855
    [PubMed - indexed for MEDLINE]
    17.

    Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of Notch signaling in cancer.

    Mamaeva V, Rosenholm JM, Bate-Eya LT, Bergman L, Peuhu E, Duchanoy A, Fortelius LE, Landor S, Toivola DM, Lindén M, Sahlgren C.

    Mol Ther. 2011 Aug;19(8):1538-46. doi: 10.1038/mt.2011.105. Epub 2011 May 31.

    PMID:
    21629222
    [PubMed - indexed for MEDLINE]
    18.

    Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma.

    Plentz R, Park JS, Rhim AD, Abravanel D, Hezel AF, Sharma SV, Gurumurthy S, Deshpande V, Kenific C, Settleman J, Majumder PK, Stanger BZ, Bardeesy N.

    Gastroenterology. 2009 May;136(5):1741-9.e6. Epub 2009 Jan 14.

    PMID:
    19208345
    [PubMed - indexed for MEDLINE]
    19.

    Gamma-secretase inhibitors enhance taxane-induced mitotic arrest and apoptosis in colon cancer cells.

    Akiyoshi T, Nakamura M, Yanai K, Nagai S, Wada J, Koga K, Nakashima H, Sato N, Tanaka M, Katano M.

    Gastroenterology. 2008 Jan;134(1):131-44. Epub 2007 Oct 9.

    PMID:
    18166351
    [PubMed - indexed for MEDLINE]
    20.

    Notch signaling, gamma-secretase inhibitors, and cancer therapy.

    Shih IeM, Wang TL.

    Cancer Res. 2007 Mar 1;67(5):1879-82. Review.

    PMID:
    17332312
    [PubMed - indexed for MEDLINE]
    Free Article

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