PubMed

Pairwise and higher-order correlations among drug-resistance mutations in HIV-1 subtype B protease.

Haq O, Levy RM, Morozov AV, Andrec M.

BMC Bioinformatics. 2009 Aug 27;10 Suppl 8:S10.PMID: 19758465 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein promiscuity: drug resistance and native functions--HIV-1 case.

Fernández A, Tawfik DS, Berkhout B, Sanders R, Kloczkowski A, Sen T, Jernigan B.

J Biomol Struct Dyn. 2005 Jun;22(6):615-24.PMID: 15842167 [PubMed - indexed for MEDLINE]Related articlesFree article

Lopinavir/ritonavir: a review of its use in the management of HIV infection.

Cvetkovic RS, Goa KL.

Drugs. 2003;63(8):769-802. Review.PMID: 12662125 [PubMed - indexed for MEDLINE]Related articles

Amplification of the effects of drug resistance mutations by background polymorphisms in HIV-1 protease from African subtypes.

Velazquez-Campoy A, Vega S, Freire E.

Biochemistry. 2002 Jul 9;41(27):8613-9.PMID: 12093278 [PubMed - indexed for MEDLINE]Related articles

Genetic diversity of protease and reverse transcriptase sequences in non-subtype-B human immunodeficiency virus type 1 strains: evidence of many minor drug resistance mutations in treatment-naive patients.

Vergne L, Peeters M, Mpoudi-Ngole E, Bourgeois A, Liegeois F, Toure-Kane C, Mboup S, Mulanga-Kabeya C, Saman E, Jourdan J, Reynes J, Delaporte E.

J Clin Microbiol. 2000 Nov;38(11):3919-25.PMID: 11060045 [PubMed - indexed for MEDLINE]Related articlesFree article

Increasing prevalence of HIV-1 protease inhibitor-associated mutations correlates with long-term non-suppressive protease inhibitor treatment.

Kagan RM, Cheung PK, Huard TK, Lewinski MA.

Antiviral Res. 2006 Aug;71(1):42-52. Epub 2006 Mar 23.PMID: 16600392 [PubMed - indexed for MEDLINE]Related articles

Protease sequences from HIV-1 group M subtypes A-H reveal distinct amino acid mutation patterns associated with protease resistance in protease inhibitor-naive individuals worldwide. HIV Variant Working Group.

Pieniazek D, Rayfield M, Hu DJ, Nkengasong J, Wiktor SZ, Downing R, Biryahwaho B, Mastro T, Tanuri A, Soriano V, Lal R, Dondero T.

AIDS. 2000 Jul 28;14(11):1489-95.PMID: 10983635 [PubMed - indexed for MEDLINE]Related articles

Resilience to resistance of HIV-1 protease inhibitors: profile of darunavir.

Lefebvre E, Schiffer CA.

AIDS Rev. 2008 Jul-Sep;10(3):131-42. Review.PMID: 18820715 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments.

Garriga C, Pérez-Elías MJ, Delgado R, Ruiz L, Nájera R, Pumarola T, Alonso-Socas Mdel M, García-Bujalance S, Menéndez-Arias L; Spanish Group for the Study of Antiretroviral Drug Resistance.

J Med Virol. 2007 Nov;79(11):1617-28.PMID: 17854027 [PubMed - indexed for MEDLINE]Related articles

Prediction of HIV-1 protease inhibitor resistance using a protein-inhibitor flexible docking approach.

Jenwitheesuk E, Samudrala R.

Antivir Ther. 2005;10(1):157-66.PMID: 15751773 [PubMed - indexed for MEDLINE]Related articles

Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments.

Wu TD, Schiffer CA, Gonzales MJ, Taylor J, Kantor R, Chou S, Israelski D, Zolopa AR, Fessel WJ, Shafer RW.

J Virol. 2003 Apr;77(8):4836-47.PMID: 12663790 [PubMed - indexed for MEDLINE]Related articlesFree article

The impact of individual human immunodeficiency virus type 1 protease mutations on drug susceptibility is highly influenced by complex interactions with the background protease sequence.

Van Marck H, Dierynck I, Kraus G, Hallenberger S, Pattery T, Muyldermans G, Geeraert L, Borozdina L, Bonesteel R, Aston C, Shaw E, Chen Q, Martinez C, Koka V, Lee J, Chi E, de Béthune MP, Hertogs K.

J Virol. 2009 Sep;83(18):9512-20. Epub 2009 Jul 8.PMID: 19587054 [PubMed - indexed for MEDLINE]Related articles

Structural and thermodynamic basis of resistance to HIV-1 protease inhibition: implications for inhibitor design.

Velazquez-Campoy A, Muzammil S, Ohtaka H, Schön A, Vega S, Freire E.

Curr Drug Targets Infect Disord. 2003 Dec;3(4):311-28. Review.PMID: 14754432 [PubMed - indexed for MEDLINE]Related articles

Study of the impact of HIV genotypic drug resistance testing on therapy efficacy.

Van Vaerenbergh K.

Verh K Acad Geneeskd Belg. 2001;63(5):447-73. Review.PMID: 11813503 [PubMed - indexed for MEDLINE]Related articles

A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance.

Muzammil S, Ross P, Freire E.

Biochemistry. 2003 Jan 28;42(3):631-8.PMID: 12534275 [PubMed - indexed for MEDLINE]Related articles

Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure.

Dumans AT, Barreto CC, Santos AF, Arruda M, Sousa TM, Machado ES, Sabino EC, Brindeiro RM, Tanuri A, Duarte AJ, Soares MA.

Infect Genet Evol. 2009 Jan;9(1):62-70. Epub 2008 Oct 17.PMID: 18992847 [PubMed - indexed for MEDLINE]Related articles

A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism.

Nijhuis M, van Maarseveen NM, Lastere S, Schipper P, Coakley E, Glass B, Rovenska M, de Jong D, Chappey C, Goedegebuure IW, Heilek-Snyder G, Dulude D, Cammack N, Brakier-Gingras L, Konvalinka J, Parkin N, Kräusslich HG, Brun-Vezinet F, Boucher CA.

PLoS Med. 2007 Jan;4(1):e36.PMID: 17227139 [PubMed - indexed for MEDLINE]Related articlesFree article

Positive selection detection in 40,000 human immunodeficiency virus (HIV) type 1 sequences automatically identifies drug resistance and positive fitness mutations in HIV protease and reverse transcriptase.

Chen L, Perlina A, Lee CJ.

J Virol. 2004 Apr;78(7):3722-32.PMID: 15016892 [PubMed - indexed for MEDLINE]Related articlesFree article

A mutation in human immunodeficiency virus type 1 protease at position 88, located outside the active site, confers resistance to the hydroxyethylurea inhibitor SC-55389A.

Smidt ML, Potts KE, Tucker SP, Blystone L, Stiebel TR Jr, Stallings WC, McDonald JJ, Pillay D, Richman DD, Bryant ML.

Antimicrob Agents Chemother. 1997 Mar;41(3):515-22.PMID: 9055985 [PubMed - indexed for MEDLINE]Related articlesFree article

HIV-1 subtype C reverse transcriptase and protease genotypes in Zimbabwean patients failing antiretroviral therapy.

Kantor R, Zijenah LS, Shafer RW, Mutetwa S, Johnston E, Lloyd R, von Lieven A, Israelski D, Katzenstein DA.

AIDS Res Hum Retroviruses. 2002 Dec 10;18(18):1407-13.PMID: 12512512 [PubMed - indexed for MEDLINE]Related articlesFree article