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Involvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposure.

Behl M, Zhang Y, Zheng W.

Cerebrospinal Fluid Res. 2009 Sep 11;6:11.PMID: 19747378 [PubMed - in process]Free PMC ArticleFree textRelated citations

Increased beta-amyloid levels in the choroid plexus following lead exposure and the involvement of low-density lipoprotein receptor protein-1.

Behl M, Zhang Y, Monnot AD, Jiang W, Zheng W.

Toxicol Appl Pharmacol. 2009 Oct 15;240(2):245-54. Epub 2009 Jun 6.PMID: 19501112 [PubMed - indexed for MEDLINE]Related citations

Lead-induced accumulation of beta-amyloid in the choroid plexus: Role of low density lipoprotein receptor protein-1 and protein kinase C.

Behl M, Zhang Y, Shi Y, Cheng J, Du Y, Zheng W.

Neurotoxicology. 2010 May 19. [Epub ahead of print]PMID: 20488202 [PubMed - as supplied by publisher]Related citations

GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice.

Tian J, Shi J, Zhang L, Yin J, Hu Q, Xu Y, Sheng S, Wang P, Ren Y, Wang R, Wang Y.

Curr Alzheimer Res. 2009 Apr;6(2):118-31.PMID: 19355846 [PubMed - indexed for MEDLINE]Related citations

Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy.

Morelli L, Llovera RE, Mathov I, Lue LF, Frangione B, Ghiso J, Castaño EM.

J Biol Chem. 2004 Dec 31;279(53):56004-13. Epub 2004 Oct 15.PMID: 15489232 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.

Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ.

J Neurosci. 2000 Mar 1;20(5):1657-65.PMID: 10684867 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.

Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ.

J Biol Chem. 1998 Dec 4;273(49):32730-8.PMID: 9830016 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Abeta and insulin degradation.

Bulloj A, Leal MC, Surace EI, Zhang X, Xu H, Ledesma MD, Castaño EM, Morelli L.

Mol Neurodegener. 2008 Dec 31;3:22.PMID: 19117523 [PubMed - in process]Free PMC ArticleFree textRelated citations

Macromolecules involved in production and metabolism of beta-amyloid at the brain barriers.

Crossgrove JS, Smith EL, Zheng W.

Brain Res. 2007 Mar 23;1138:187-95. Epub 2007 Feb 2.PMID: 17276414 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Expression and functional profiling of neprilysin, insulin degrading enzyme and endothelin converting enzyme in prospectively studied elderly and Alzheimer's brain.

Wang S, Wang R, Chen L, Bennett DA, Dickson DW, Wang DS.

J Neurochem. 2010 Jul 17. [Epub ahead of print]PMID: 20663017 [PubMed - as supplied by publisher]Related citations

Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.

Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ.

Biochemistry. 2005 May 3;44(17):6513-25.PMID: 15850385 [PubMed - indexed for MEDLINE]Related citations

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.

Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ.

Am J Pathol. 2004 Apr;164(4):1425-34.PMID: 15039230 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Insulin-Degrading Enzyme Sorting in Exosomes: A Secretory Pathway for a Key Brain Amyloid-beta Degrading Protease.

Bulloj A, Leal MC, Xu H, Castaño EM, Morelli L.

J Alzheimers Dis. 2009 Sep 11. [Epub ahead of print]PMID: 19749427 [PubMed - as supplied by publisher]Related citations

Insulin-degrading enzyme sorting in exosomes: a secretory pathway for a key brain amyloid-beta degrading protease.

Bulloj A, Leal MC, Xu H, Castaño EM, Morelli L.

J Alzheimers Dis. 2010 Jan;19(1):79-95.PMID: 20061628 [PubMed - in process]Related citations

The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis.

Llovera RE, de Tullio M, Alonso LG, Leissring MA, Kaufman SB, Roher AE, de Prat Gay G, Morelli L, Castaño EM.

J Biol Chem. 2008 Jun 20;283(25):17039-48. Epub 2008 Apr 14.PMID: 18411275 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation.

Cordes CM, Bennett RG, Siford GL, Hamel FG.

Biochem Pharmacol. 2009 Mar 15;77(6):1064-73. Epub 2008 Dec 27.PMID: 19154729 [PubMed - indexed for MEDLINE]Related citations

Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro.

Wang X, Li GJ, Zheng W.

Brain Res. 2006 Jun 30;1097(1):1-10. Epub 2006 May 26.PMID: 16729984 [PubMed - indexed for MEDLINE]Related citations

Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization.

Chesneau V, Vekrellis K, Rosner MR, Selkoe DJ.

Biochem J. 2000 Oct 15;351 Pt 2:509-16.PMID: 11023838 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Lead exposure promotes translocation of protein kinase C activities in rat choroid plexus in vitro, but not in vivo.

Zhao Q, Slavkovich V, Zheng W.

Toxicol Appl Pharmacol. 1998 Mar;149(1):99-106.PMID: 9512732 [PubMed - indexed for MEDLINE]Related citations

Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures.

Lynch JA, George AM, Eisenhauer PB, Conn K, Gao W, Carreras I, Wells JM, McKee A, Ullman MD, Fine RE.

J Neurosci Res. 2006 May 15;83(7):1262-70.PMID: 16511862 [PubMed - indexed for MEDLINE]Related citations