PubMed

Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors.

Pita-Lopez ML, Gayoso I, Delarosa O, Casado JG, Alonso C, Muñoz-Gomariz E, Tarazona R, Solana R.

Immun Ageing. 2009 Aug 28;6:11.PMID: 19715573 [PubMed - in process]Related articlesFree article

High frequencies cytomegalovirus pp65(495-503)-specific CD8+ T cells in healthy young and elderly Chinese donors: characterization of their phenotypes and TCR Vbeta usage.

He XH, Zha QB, Liu Y, Xu LH, Chi XY.

J Clin Immunol. 2006 Sep;26(5):417-29. Epub 2006 Jul 19.PMID: 16850281 [PubMed - indexed for MEDLINE]Related articles

Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals.

Khan N, Shariff N, Cobbold M, Bruton R, Ainsworth JA, Sinclair AJ, Nayak L, Moss PA.

J Immunol. 2002 Aug 15;169(4):1984-92.PMID: 12165524 [PubMed - indexed for MEDLINE]Related articlesFree article

The immune system in extreme longevity.

Sansoni P, Vescovini R, Fagnoni F, Biasini C, Zanni F, Zanlari L, Telera A, Lucchini G, Passeri G, Monti D, Franceschi C, Passeri M.

Exp Gerontol. 2008 Feb;43(2):61-5. Epub 2007 Jul 4. Review.PMID: 17870272 [PubMed - indexed for MEDLINE]Related articles

Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1).

Ouyang Q, Wagner WM, Voehringer D, Wikby A, Klatt T, Walter S, Müller CA, Pircher H, Pawelec G.

Exp Gerontol. 2003 Aug;38(8):911-20.PMID: 12915213 [PubMed - indexed for MEDLINE]Related articles

Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly.

Ouyang Q, Wagner WM, Zheng W, Wikby A, Remarque EJ, Pawelec G.

Exp Gerontol. 2004 Apr;39(4):607-13.PMID: 15050296 [PubMed - indexed for MEDLINE]Related articles

Age-dependent association between low frequency of CD27/CD28 expression on pp65 CD8+ T cells and cytomegalovirus replication after transplantation.

Cantisán S, Torre-Cisneros J, Lara R, Rodríguez-Benot A, Santos F, Gutiérrez-Aroca J, Gayoso I, González-Padilla M, Casal M, Rivero A, Solana R.

Clin Vaccine Immunol. 2009 Oct;16(10):1429-38. Epub 2009 Aug 5.PMID: 19656991 [PubMed - indexed for MEDLINE]Related articles

Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly.

Weinberger B, Lazuardi L, Weiskirchner I, Keller M, Neuner C, Fischer KH, Neuman B, Würzner R, Grubeck-Loebenstein B.

Hum Immunol. 2007 Feb;68(2):86-90. Epub 2006 Dec 5.PMID: 17321897 [PubMed - indexed for MEDLINE]Related articles

Large scale analysis of pediatric antiviral CD8+ T cell populations reveals sustained, functional and mature responses.

Komatsu H, Inui A, Sogo T, Fujisawa T, Nagasaka H, Nonoyama S, Sierro S, Northfield J, Lucas M, Vargas A, Klenerman P.

Immun Ageing. 2006 Dec 8;3:11.PMID: 17156440 [PubMed]Related articlesFree article

Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons.

Almanzar G, Schwaiger S, Jenewein B, Keller M, Herndler-Brandstetter D, Würzner R, Schönitzer D, Grubeck-Loebenstein B.

J Virol. 2005 Mar;79(6):3675-83.PMID: 15731261 [PubMed - indexed for MEDLINE]Related articlesFree article

Protective immunity to cytomegalovirus (CMV) retinitis in AIDS is associated with CMV-specific T cells that express interferon- gamma and interleukin-2 and have a CD8+ cell early maturational phenotype.

Sinclair E, Tan QX, Sharp M, Girling V, Poon C, Natta MV, Jabs DA, Inokuma M, Maecker HT, Bredt B, Jacobson MA; Studies of Ocular Complications of AIDS Research Group.

J Infect Dis. 2006 Dec 1;194(11):1537-46. Epub 2006 Oct 26.PMID: 17083038 [PubMed - indexed for MEDLINE]Related articles

Does memory improve with age? CD85j (ILT-2/LIR-1) expression on CD8 T cells correlates with 'memory inflation' in human cytomegalovirus infection.

Northfield J, Lucas M, Jones H, Young NT, Klenerman P.

Immunol Cell Biol. 2005 Apr;83(2):182-8.PMID: 15748215 [PubMed - indexed for MEDLINE]Related articles

Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection.

Khan N, Hislop A, Gudgeon N, Cobbold M, Khanna R, Nayak L, Rickinson AB, Moss PA.

J Immunol. 2004 Dec 15;173(12):7481-9.PMID: 15585874 [PubMed - indexed for MEDLINE]Related articlesFree article

Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly.

Hadrup SR, Strindhall J, Køllgaard T, Seremet T, Johansson B, Pawelec G, thor Straten P, Wikby A.

J Immunol. 2006 Feb 15;176(4):2645-53.PMID: 16456027 [PubMed - indexed for MEDLINE]Related articlesFree article

Age-related appearance of a CMV-specific high-avidity CD8+ T cell clonotype which does not occur in young adults.

Schwanninger A, Weinberger B, Weiskopf D, Herndler-Brandstetter D, Reitinger S, Gassner C, Schennach H, Parson W, Würzner R, Grubeck-Loebenstein B.

Immun Ageing. 2008 Nov 12;5:14.PMID: 19014475 [PubMed - in process]Related articlesFree article

Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily.

Colonna-Romano G, Akbar AN, Aquino A, Bulati M, Candore G, Lio D, Ammatuna P, Fletcher JM, Caruso C, Pawelec G.

Exp Gerontol. 2007 Oct;42(10):995-1002. Epub 2007 May 23.PMID: 17611062 [PubMed - indexed for MEDLINE]Related articles

Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals.

Chidrawar S, Khan N, Wei W, McLarnon A, Smith N, Nayak L, Moss P.

Clin Exp Immunol. 2009 Mar;155(3):423-32.PMID: 19220832 [PubMed - indexed for MEDLINE]Related articlesFree article

Expansion of CMV-specific CD8+CD45RA+CD27- T cells in B-cell chronic lymphocytic leukemia.

Mackus WJ, Frakking FN, Grummels A, Gamadia LE, De Bree GJ, Hamann D, Van Lier RA, Van Oers MH.

Blood. 2003 Aug 1;102(3):1057-63. Epub 2003 Apr 10.PMID: 12689926 [PubMed - indexed for MEDLINE]Related articlesFree article

Repertoire, diversity, and differentiation of specific CD8 T cells are associated with immune protection against human cytomegalovirus disease.

Sacre K, Carcelain G, Cassoux N, Fillet AM, Costagliola D, Vittecoq D, Salmon D, Amoura Z, Katlama C, Autran B.

J Exp Med. 2005 Jun 20;201(12):1999-2010.PMID: 15967826 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals.

Kern F, Bunde T, Faulhaber N, Kiecker F, Khatamzas E, Rudawski IM, Pruss A, Gratama JW, Volkmer-Engert R, Ewert R, Reinke P, Volk HD, Picker LJ.

J Infect Dis. 2002 Jun 15;185(12):1709-16. Epub 2002 May 31.PMID: 12085315 [PubMed - indexed for MEDLINE]Related articles