PubMed

Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC-1 cancer cells.

Hutzen B, Willis W, Jones S, Cen L, Deangelis S, Fuh B, Lin J.

Cancer Cell Int. 2009 Aug 27;9:24.PMID: 19712481 [PubMed]Free ArticleRelated citations

The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate.

Sahu RP, Srivastava SK.

J Natl Cancer Inst. 2009 Feb 4;101(3):176-93. Epub 2009 Jan 27.PMID: 19176463 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells.

Duan Z, Bradner J, Greenberg E, Mazitschek R, Foster R, Mahoney J, Seiden MV.

Mol Pharmacol. 2007 Nov;72(5):1137-45. Epub 2007 Aug 3.PMID: 17675586 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells.

Shin DS, Kim HN, Shin KD, Yoon YJ, Kim SJ, Han DC, Kwon BM.

Cancer Res. 2009 Jan 1;69(1):193-202.PMID: 19118003 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

New curcumin analogues exhibit enhanced growth-suppressive activity and inhibit AKT and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells.

Lin L, Hutzen B, Ball S, Foust E, Sobo M, Deangelis S, Pandit B, Friedman L, Li C, Li PK, Fuchs J, Lin J.

Cancer Sci. 2009 Sep;100(9):1719-27. Epub 2009 May 18.PMID: 19558577 [PubMed - indexed for MEDLINE]Related citations

Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells.

Sahu RP, Zhang R, Batra S, Shi Y, Srivastava SK.

Carcinogenesis. 2009 Oct;30(10):1744-53. Epub 2009 Jun 23.PMID: 19549704 [PubMed - indexed for MEDLINE]Related citations

Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells.

Lin L, Hutzen B, Zuo M, Ball S, Deangelis S, Foust E, Pandit B, Ihnat MA, Shenoy SS, Kulp S, Li PK, Li C, Fuchs J, Lin J.

Cancer Res. 2010 Mar 15;70(6):2445-54. Epub 2010 Mar 9.PMID: 20215512 [PubMed - indexed for MEDLINE]Related citations

Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas.

Hutzen B, Friedman L, Sobo M, Lin L, Cen L, De Angelis S, Yamakoshi H, Shibata H, Iwabuchi Y, Lin J.

Int J Oncol. 2009 Oct;35(4):867-72.PMID: 19724924 [PubMed - indexed for MEDLINE]Related citations

Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines.

Tseng E, Scott-Ramsay EA, Morris ME.

Exp Biol Med (Maywood). 2004 Sep;229(8):835-42.PMID: 15337839 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding.

Sen B, Saigal B, Parikh N, Gallick G, Johnson FM.

Cancer Res. 2009 Mar 1;69(5):1958-65. Epub 2009 Feb 17.PMID: 19223541 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival.

Chen CL, Cen L, Kohout J, Hutzen B, Chan C, Hsieh FC, Loy A, Huang V, Cheng G, Lin J.

Mol Cancer. 2008 Oct 21;7:78.PMID: 18939995 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells.

Chen CL, Loy A, Cen L, Chan C, Hsieh FC, Cheng G, Wu B, Qualman SJ, Kunisada K, Yamauchi-Takihara K, Lin J.

BMC Cancer. 2007 Jun 28;7:111.PMID: 17598902 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: effects of indole-3-carbinol (I3C) and genistein.

Lian JP, Word B, Taylor S, Hammons GJ, Lyn-Cook BD.

Anticancer Res. 2004 Jan-Feb;24(1):133-7.PMID: 15015587 [PubMed - indexed for MEDLINE]Related citations

p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression.

Kim SH, Singh SV.

Cancer Prev Res (Phila Pa). 2010 Jun;3(6):718-26. Epub 2010 May 18.PMID: 20484174 [PubMed - in process]Related citations

Benzyl isothiocyanate (BITC) inhibits migration and invasion of human gastric cancer AGS cells via suppressing ERK signal pathways.

Ho CC, Lai KC, Hsu SC, Kuo CL, Ma CY, Lin ML, Yang JS, Chung JG.

Hum Exp Toxicol. 2010 May 24. [Epub ahead of print]PMID: 20498032 [PubMed - as supplied by publisher]Related citations

17-hydroxy-jolkinolide B inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking Janus kinases and induces apoptosis of human cancer cells.

Wang Y, Ma X, Yan S, Shen S, Zhu H, Gu Y, Wang H, Qin G, Yu Q.

Cancer Res. 2009 Sep 15;69(18):7302-10. Epub 2009 Aug 25.PMID: 19706767 [PubMed - indexed for MEDLINE]Related citations

Phenethyl isothiocyanate inhibits STAT3 activation in prostate cancer cells.

Gong A, He M, Krishna Vanaja D, Yin P, Karnes RJ, Young CY.

Mol Nutr Food Res. 2009 Jul;53(7):878-86.PMID: 19437484 [PubMed - indexed for MEDLINE]Related citations

Stress-associated hormone, norepinephrine, increases proliferation and IL-6 levels of human pancreatic duct epithelial cells and can be inhibited by the dietary agent, sulforaphane.

Chan C, Lin HJ, Lin J.

Int J Oncol. 2008 Aug;33(2):415-9.PMID: 18636164 [PubMed - indexed for MEDLINE]Related citations

MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion.

Gao J, McConnell MJ, Yu B, Li J, Balko JM, Black EP, Johnson JO, Lloyd MC, Altiok S, Haura EB.

Int J Oncol. 2009 Aug;35(2):337-45.PMID: 19578748 [PubMed - indexed for MEDLINE]Related citations

Inhibition of pancreatic cancer cell growth by cucurbitacin B through modulation of signal transducer and activator of transcription 3 signaling.

Zhang M, Sun C, Shan X, Yang X, Li-Ling J, Deng Y.

Pancreas. 2010 Aug;39(6):923-9.PMID: 20182390 [PubMed - in process]Related citations