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    Results: 1 to 20 of 160

    1.

    BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A.

    Puppe J, Drost R, Liu X, Joosse SA, Evers B, Cornelissen-Steijger P, Nederlof P, Yu Q, Jonkers J, van Lohuizen M, Pietersen AM.

    Breast Cancer Res. 2009;11(4):R63. Epub 2009 Aug 26.

    PMID:
    19709408
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    2.

    Development of 'synthetic lethal' strategies to target BRCA1-deficient breast cancer.

    Wicha MS.

    Breast Cancer Res. 2009;11(5):108. Epub .

    PMID:
    19804613
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    3.

    Final Report on Carcinogens Background Document for Styrene.

    National Toxicology Program.

    Rep Carcinog Backgr Doc. 2008 Sep;(8-5978):i-398.

    PMID:
    20737009
    [PubMed - as supplied by publisher]

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    4.

    Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer.

    Gonzalez ME, DuPrie ML, Krueger H, Merajver SD, Ventura AC, Toy KA, Kleer CG.

    Cancer Res. 2011 Mar 15;71(6):2360-70.

    PMID:
    21406404
    [PubMed - indexed for MEDLINE]

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    5.

    Final Report on Carcinogens Background Document for Formaldehyde.

    National Toxicology Program.

    Rep Carcinog Backgr Doc. 2010 Jan;(10-5981):i-512.

    PMID:
    20737003
    [PubMed - as supplied by publisher]

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    6.

    Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells.

    Fiskus W, Wang Y, Sreekumar A, Buckley KM, Shi H, Jillella A, Ustun C, Rao R, Fernandez P, Chen J, Balusu R, Koul S, Atadja P, Marquez VE, Bhalla KN.

    Blood. 2009 Sep 24;114(13):2733-43. Epub 2009 Jul 28.

    PMID:
    19638619
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    7.

    Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells.

    Sun F, Chan E, Wu Z, Yang X, Marquez VE, Yu Q.

    Mol Cancer Ther. 2009 Dec;8(12):3191-202. Epub .

    PMID:
    19934278
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    8.

    Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells.

    Tan J, Yang X, Zhuang L, Jiang X, Chen W, Lee PL, Karuturi RK, Tan PB, Liu ET, Yu Q.

    Genes Dev. 2007 May 1;21(9):1050-63. Epub 2007 Apr 16.

    PMID:
    17437993
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    9.

    BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer.

    Gorski JJ, James CR, Quinn JE, Stewart GE, Staunton KC, Buckley NE, McDyer FA, Kennedy RD, Wilson RH, Mullan PB, Harkin DP.

    Breast Cancer Res Treat. 2010 Aug;122(3):721-31. Epub 2009 Oct 31.

    PMID:
    19882246
    [PubMed - indexed for MEDLINE]

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    10.

    Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer.

    Chen H, Tu SW, Hsieh JT.

    J Biol Chem. 2005 Jun 10;280(23):22437-44. Epub 2005 Apr 6.

    PMID:
    15817459
    [PubMed - indexed for MEDLINE]
    Free Article

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    11.

    Genomic signature of BRCA1 deficiency in sporadic basal-like breast tumors.

    Joosse SA, Brandwijk KI, Mulder L, Wesseling J, Hannemann J, Nederlof PM.

    Genes Chromosomes Cancer. 2011 Feb;50(2):71-81.

    PMID:
    21104783
    [PubMed - indexed for MEDLINE]

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    12.

    Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers.

    Deans AJ, Khanna KK, McNees CJ, Mercurio C, Heierhorst J, McArthur GA.

    Cancer Res. 2006 Aug 15;66(16):8219-26.

    PMID:
    16912201
    [PubMed - indexed for MEDLINE]
    Free Article

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    13.

    The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML.

    Zhou J, Bi C, Cheong LL, Mahara S, Liu SC, Tay KG, Koh TL, Yu Q, Chng WJ.

    Blood. 2011 Sep 8;118(10):2830-9. Epub 2011 Jul 6.

    PMID:
    21734239
    [PubMed - indexed for MEDLINE]

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    14.

    Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer.

    Hosey AM, Gorski JJ, Murray MM, Quinn JE, Chung WY, Stewart GE, James CR, Farragher SM, Mulligan JM, Scott AN, Dervan PA, Johnston PG, Couch FJ, Daly PA, Kay E, McCann A, Mullan PB, Harkin DP.

    J Natl Cancer Inst. 2007 Nov 21;99(22):1683-94. Epub 2007 Nov 13.

    PMID:
    18000219
    [PubMed - indexed for MEDLINE]
    Free Article

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    15.

    c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells.

    Chen Y, Xu J, Borowicz S, Collins C, Huo D, Olopade OI.

    BMC Cancer. 2011 Jun 13;11:246.

    PMID:
    21668996
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    16.

    The cell of origin of BRCA1 mutation-associated breast cancer: a cautionary tale of gene expression profiling.

    Molyneux G, Smalley MJ.

    J Mammary Gland Biol Neoplasia. 2011 Apr;16(1):51-5. Epub 2011 Feb 19. Review.

    PMID:
    21336547
    [PubMed - indexed for MEDLINE]

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    17.

    Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer.

    Berezovska OP, Glinskii AB, Yang Z, Li XM, Hoffman RM, Glinsky GV.

    Cell Cycle. 2006 Aug;5(16):1886-901. Epub 2006 Aug 15.

    PMID:
    16963837
    [PubMed - indexed for MEDLINE]
    Free Article

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    18.

    Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia.

    Li X, Gonzalez ME, Toy K, Filzen T, Merajver SD, Kleer CG.

    Am J Pathol. 2009 Sep;175(3):1246-54. Epub 2009 Aug 6.

    PMID:
    19661437
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    19.

    Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer.

    Liu X, Holstege H, van der Gulden H, Treur-Mulder M, Zevenhoven J, Velds A, Kerkhoven RM, van Vliet MH, Wessels LF, Peterse JL, Berns A, Jonkers J.

    Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12111-6. Epub 2007 Jul 11.

    PMID:
    17626182
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    20.

    Therapeutic exploitation of tumor cell defects in homologous recombination.

    Powell SN, Kachnic LA.

    Anticancer Agents Med Chem. 2008 May;8(4):448-60. Review.

    PMID:
    18473729
    [PubMed - indexed for MEDLINE]

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