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    Results: 1 to 20 of 99

    1.

    Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells.

    Nakamura T, Watanabe A, Fujino T, Hosono T, Michikawa M.

    Mol Neurodegener. 2009 Aug 20;4:35.

    PMID:
    19695092
    [PubMed - in process]
    Free PMC Article
    2.

    Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.

    Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW.

    J Biol Chem. 2011 Feb 18;286(7):5215-21. Epub 2010 Nov 30.

    PMID:
    21118811
    [PubMed - indexed for MEDLINE]
    3.

    Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.

    Chang S, ran Ma T, Miranda RD, Balestra ME, Mahley RW, Huang Y.

    Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18694-9. Epub 2005 Dec 12.

    PMID:
    16344479
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    4.

    Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.

    Mahley RW, Weisgraber KH, Huang Y.

    Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5644-51. Epub 2006 Mar 27. Review.

    PMID:
    16567625
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    5.

    Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

    Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y.

    J Neurosci. 2004 Mar 10;24(10):2527-34.

    PMID:
    15014128
    [PubMed - indexed for MEDLINE]
    Free Article
    6.

    Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease.

    Aleshkov S, Abraham CR, Zannis VI.

    Biochemistry. 1997 Aug 26;36(34):10571-80.

    PMID:
    9265639
    [PubMed - indexed for MEDLINE]
    7.

    Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients.

    Ji Y, Gong Y, Gan W, Beach T, Holtzman DM, Wisniewski T.

    Neuroscience. 2003;122(2):305-15.

    PMID:
    14614898
    [PubMed - indexed for MEDLINE]
    8.

    C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice.

    Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Wang C, Huang Y.

    Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4236-41. Epub 2011 Feb 22.

    PMID:
    21368138
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    9.

    Apolipoprotein E. Structure, function, and possible roles in Alzheimer's disease.

    Mahley RW, Nathan BP, Pitas RE.

    Ann N Y Acad Sci. 1996 Jan 17;777:139-45. Review.

    PMID:
    8624076
    [PubMed - indexed for MEDLINE]
    10.

    Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.

    Devi L, Prabhu BM, Galati DF, Avadhani NG, Anandatheerthavarada HK.

    J Neurosci. 2006 Aug 30;26(35):9057-68.

    PMID:
    16943564
    [PubMed - indexed for MEDLINE]
    Free Article
    11.

    Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.

    Sanan DA, Weisgraber KH, Russell SJ, Mahley RW, Huang D, Saunders A, Schmechel D, Wisniewski T, Frangione B, Roses AD, et al.

    J Clin Invest. 1994 Aug;94(2):860-9.

    PMID:
    8040342
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    12.

    A 13 kDa carboxy-terminal fragment of ApoE stabilizes Abeta hexamers.

    Wellnitz S, Friedlein A, Bonanni C, Anquez V, Goepfert F, Loetscher H, Adessi C, Czech C.

    J Neurochem. 2005 Sep;94(5):1351-60. Epub 2005 Jul 11.

    PMID:
    16011742
    [PubMed - indexed for MEDLINE]
    13.

    Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice.

    Gong JS, Kobayashi M, Hayashi H, Zou K, Sawamura N, Fujita SC, Yanagisawa K, Michikawa M.

    J Biol Chem. 2002 Aug 16;277(33):29919-26. Epub 2002 May 31.

    PMID:
    12042316
    [PubMed - indexed for MEDLINE]
    Free Article
    14.

    Small-Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons.

    Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, Weisgraber KH, Huang Y, Mahley RW.

    J Biol Chem. 2011 Dec 12. [Epub ahead of print]

    PMID:
    22158868
    [PubMed - as supplied by publisher]
    Free Article
    15.

    Characterization of the binding of amyloid-beta peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma.

    Yang DS, Smith JD, Zhou Z, Gandy SE, Martins RN.

    J Neurochem. 1997 Feb;68(2):721-5.

    PMID:
    9003062
    [PubMed - indexed for MEDLINE]
    16.

    Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E.

    Raffai RL, Dong LM, Farese RV Jr, Weisgraber KH.

    Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11587-91. Epub 2001 Sep 11.

    PMID:
    11553788
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    17.

    Structural and functional variations in human apolipoprotein E3 and E4.

    Chou CY, Jen WP, Hsieh YH, Shiao MS, Chang GG.

    J Biol Chem. 2006 May 12;281(19):13333-44. Epub 2006 Mar 14.

    PMID:
    16540478
    [PubMed - indexed for MEDLINE]
    Free Article
    18.

    Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.

    Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW.

    Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8838-43. Epub 2001 Jul 10.

    PMID:
    11447277
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    19.

    Structural variation in human apolipoprotein E3 and E4: secondary structure, tertiary structure, and size distribution.

    Chou CY, Lin YL, Huang YC, Sheu SY, Lin TH, Tsay HJ, Chang GG, Shiao MS.

    Biophys J. 2005 Jan;88(1):455-66. Epub 2004 Oct 8.

    PMID:
    15475580
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    20.

    Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer.

    Xu Q, Brecht WJ, Weisgraber KH, Mahley RW, Huang Y.

    J Biol Chem. 2004 Jun 11;279(24):25511-6. Epub 2004 Mar 30.

    PMID:
    15054100
    [PubMed - indexed for MEDLINE]
    Free Article

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