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Trypanocidal activity of the proteasome inhibitor and anti-cancer drug bortezomib.

Steverding D, Wang X.

Parasit Vectors. 2009 Jul 7;2(1):29.PMID: 19583840 [PubMed - in process]Related articlesFree article

Evaluation of the anti-trypanosomal activity of tyropeptin A.

Steverding D, Pemberton AJ, Royle H, Spackman RW, Rivett AJ.

Planta Med. 2006 Jun;72(8):761-3. Epub 2006 May 29.PMID: 16732530 [PubMed - indexed for MEDLINE]Related articles

In vitro trypanocidal activity of the anti-helminthic drug niclosamide.

Merschjohann K, Steverding D.

Exp Parasitol. 2008 Apr;118(4):637-40. Epub 2007 Dec 15.PMID: 18226810 [PubMed - indexed for MEDLINE]Related articles

Antitrypanosomal activities of proteasome inhibitors.

Nkemngu NJ, Rosenkranz V, Wink M, Steverding D.

Antimicrob Agents Chemother. 2002 Jun;46(6):2038-40. Erratum in: Antimicrob Agents Chemother. 2003 Sep;47(9):3036. Nkemgu-Njinkeng, Joseph [corrected to Nkemngu, Njinkeng Joseph]. PMID: 12019136 [PubMed - indexed for MEDLINE]Related articlesFree article

Trypanocidal effect of alpha',beta'-epoxyketones indicates that trypanosomes are particularly sensitive to inhibitors of proteasome trypsin-like activity.

Glenn RJ, Pemberton AJ, Royle HJ, Spackman RW, Smith E, Jennifer Rivett A, Steverding D.

Int J Antimicrob Agents. 2004 Sep;24(3):286-9.PMID: 15325434 [PubMed - indexed for MEDLINE]Related articles

Anti-trypanosomal activities of DNA topoisomerase inhibitors.

Deterding A, Dungey FA, Thompson KA, Steverding D.

Acta Trop. 2005 Mar;93(3):311-6.PMID: 15715983 [PubMed - indexed for MEDLINE]Related articles

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis.

Rodgers J, Stone TW, Barrett MP, Bradley B, Kennedy PG.

Brain. 2009 May;132(Pt 5):1259-67. Epub 2009 Mar 31.PMID: 19339256 [PubMed - indexed for MEDLINE]Related articlesFree article

Trypanocidal activities of trileucine methyl vinyl sulfone proteasome inhibitors.

Steverding D, Spackman RW, Royle HJ, Glenn RJ.

Parasitol Res. 2005 Jan;95(1):73-6. Epub 2004 Dec 1.PMID: 15578221 [PubMed - indexed for MEDLINE]Related articles

In vitro growth inhibition of bloodstream forms of Trypanosoma brucei and Trypanosoma congolense by iron chelators.

Merschjohann K, Steverding D.

Kinetoplastid Biol Dis. 2006 Aug 16;5:3.PMID: 16914038 [PubMed]Related articlesFree article

The cysteine proteinase inhibitor Z-Phe-Ala-CHN2 alters cell morphology and cell division activity of Trypanosoma brucei bloodstream forms in vivo.

Scory S, Stierhof YD, Caffrey CR, Steverding D.

Kinetoplastid Biol Dis. 2007 Feb 28;6:2.PMID: 17328798 [PubMed]Related articlesFree article

Activity of indenoisoquinolines against African trypanosomes.

Bakshi RP, Sang D, Morrell A, Cushman M, Shapiro TA.

Antimicrob Agents Chemother. 2009 Jan;53(1):123-8. Epub 2008 Sep 29.PMID: 18824603 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteasome Inhibitor Bortezomib Increases Radiation Sensitivity in Androgen Independent Human Prostate Cancer Cells.

Goktas S, Baran Y, Ural AU, Yazici S, Aydur E, Basal S, Avcu F, Pekel A, Dirican B, Beyzadeoglu M.

Urology. 2009 Oct 1. [Epub ahead of print]PMID: 19800672 [PubMed - as supplied by publisher]Related articles

The trypanocidal effect of NO-releasing agents is not due to inhibition of the major cysteine proteinase in Trypanosoma brucei.

Steverding D, Wang X, Sexton DW.

Parasitol Res. 2009 Oct;105(5):1333-8. Epub 2009 Jul 16.PMID: 19609563 [PubMed - indexed for MEDLINE]Related articles

Inhibition of proteasome activity by bortezomib in renal cancer cells is p53 dependent and VHL independent.

Vaziri SA, Grabowski DR, Hill J, Rybicki LR, Burk R, Bukowski RM, Ganapathi MK, Ganapathi R.

Anticancer Res. 2009 Aug;29(8):2961-9.PMID: 19661301 [PubMed - indexed for MEDLINE]Related articles

The proteasome inhibitor CEP-18770 enhances the anti-myeloma activity of bortezomib and melphalan.

Sanchez E, Li M, Steinberg JA, Wang C, Shen J, Bonavida B, Li ZW, Chen H, Berenson JR.

Br J Haematol. 2009 Dec 1. [Epub ahead of print]PMID: 19958357 [PubMed - as supplied by publisher]Related articles

Synthetic nonamer peptides derived from insect defensin mediate the killing of African trypanosomes in axenic culture.

Kitani H, Naessens J, Kubo M, Nakamura Y, Iraqi F, Gibson J, Yamakawa M.

Parasitol Res. 2009 Jul;105(1):217-25. Epub 2009 Mar 24.PMID: 19308456 [PubMed - indexed for MEDLINE]Related articles

Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites.

Baliani A, Peal V, Gros L, Brun R, Kaiser M, Barrett MP, Gilbert IH.

Org Biomol Chem. 2009 Mar 21;7(6):1154-66. Epub 2009 Jan 28.PMID: 19262935 [PubMed - indexed for MEDLINE]Related articles

Traversal of human and animal trypanosomes across the blood-brain barrier.

Grab DJ, Kennedy PG.

J Neurovirol. 2008 Oct;14(5):344-51. Epub 2008 Nov 18. Review.PMID: 19016378 [PubMed - indexed for MEDLINE]Related articles

Alteration to one of three adenosine transporters is associated with resistance to cymelarsan in Trypanosoma evansi.

Ross CA, Barns AM.

Parasitol Res. 1996;82(2):183-8.PMID: 8825216 [PubMed - indexed for MEDLINE]Related articles

Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites.

Cordeiro AT, Thiemann OH, Michels PA.

Bioorg Med Chem. 2009 Mar 15;17(6):2483-9. Epub 2009 Feb 4.PMID: 19231202 [PubMed - indexed for MEDLINE]Related articles