PubMed

Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain.

Guasti L, Richardson D, Jhaveri M, Eldeeb K, Barrett D, Elphick MR, Alexander SP, Kendall D, Michael GJ, Chapman V.

Mol Pain. 2009 Jul 1;5:35.PMID: 19570201 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain.

Jin SX, Zhuang ZY, Woolf CJ, Ji RR.

J Neurosci. 2003 May 15;23(10):4017-22.PMID: 12764087 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Direct evidence for spinal cord microglia in the development of a neuropathic pain-like state in mice.

Narita M, Yoshida T, Nakajima M, Narita M, Miyatake M, Takagi T, Yajima Y, Suzuki T.

J Neurochem. 2006 Jun;97(5):1337-48. Epub 2006 Apr 10.PMID: 16606373 [PubMed - indexed for MEDLINE]Related citations

Chronic intrathecal infusion of minocycline prevents the development of spinal-nerve ligation-induced pain in rats.

Lin CS, Tsaur ML, Chen CC, Wang TY, Lin CF, Lai YL, Hsu TC, Pan YY, Yang CH, Cheng JK.

Reg Anesth Pain Med. 2007 May-Jun;32(3):209-16.PMID: 17543815 [PubMed - indexed for MEDLINE]Related citations

Spinal microglial expression and mechanical hypersensitivity in a postoperative pain model: comparison with a neuropathic pain model.

Ito N, Obata H, Saito S.

Anesthesiology. 2009 Sep;111(3):640-8.PMID: 19672178 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation.

Ledeboer A, Sloane EM, Milligan ED, Frank MG, Mahony JH, Maier SF, Watkins LR.

Pain. 2005 May;115(1-2):71-83.PMID: 15836971 [PubMed - indexed for MEDLINE]Related citations

Spinal microglial proliferation is evident in a rat model of painful disc herniation both in the presence of behavioral hypersensitivity and following minocycline treatment sufficient to attenuate allodynia.

Rothman SM, Guarino BB, Winkelstein BA.

J Neurosci Res. 2009 Sep;87(12):2709-17.PMID: 19382225 [PubMed - indexed for MEDLINE]Related citations

Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats.

Scholz J, Abele A, Marian C, Häussler A, Herbert TA, Woolf CJ, Tegeder I.

Pain. 2008 Aug 15;138(1):130-42. Epub 2008 Jan 22.PMID: 18215468 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Effects of Etanercept and Minocycline in a rat model of spinal cord injury.

Marchand F, Tsantoulas C, Singh D, Grist J, Clark AK, Bradbury EJ, McMahon SB.

Eur J Pain. 2009 Aug;13(7):673-81. Epub 2008 Oct 11.PMID: 18849175 [PubMed - indexed for MEDLINE]Related citations

Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy.

Raghavendra V, Tanga F, DeLeo JA.

J Pharmacol Exp Ther. 2003 Aug;306(2):624-30. Epub 2003 May 6.PMID: 12734393 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat.

Dominguez E, Rivat C, Pommier B, Mauborgne A, Pohl M.

J Neurochem. 2008 Oct;107(1):50-60. Epub 2008 Jul 12.PMID: 18636982 [PubMed - indexed for MEDLINE]Related citations

Activated microglia contribute to the maintenance of chronic pain after spinal cord injury.

Hains BC, Waxman SG.

J Neurosci. 2006 Apr 19;26(16):4308-17.PMID: 16624951 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Systemic minocycline differentially influences changes in spinal microglial markers following formalin-induced nociception.

Li K, Fu KY, Light AR, Mao J.

J Neuroimmunol. 2010 Apr 15;221(1-2):25-31. Epub 2010 Mar 4.PMID: 20202692 [PubMed - indexed for MEDLINE]Related citations

Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain.

Mika J, Osikowicz M, Rojewska E, Korostynski M, Wawrzczak-Bargiela A, Przewlocki R, Przewlocka B.

Eur J Pharmacol. 2009 Nov 25;623(1-3):65-72. Epub 2009 Sep 17.PMID: 19766105 [PubMed - indexed for MEDLINE]Related citations

Increase in hemokinin-1 mRNA in the spinal cord during the early phase of a neuropathic pain state.

Matsumura T, Sakai A, Nagano M, Sawada M, Suzuki H, Umino M, Suzuki H.

Br J Pharmacol. 2008 Nov;155(5):767-74. Epub 2008 Jul 28.PMID: 18660829 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Analgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain.

Jhaveri MD, Richardson D, Kendall DA, Barrett DA, Chapman V.

J Neurosci. 2006 Dec 20;26(51):13318-27.PMID: 17182782 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Spinal astrocyte and microglial activation contributes to rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karch.

Jiang F, Liu T, Cheng M, Pang XY, Bai ZT, Zhou JJ, Ji YH.

Eur J Pharmacol. 2009 Nov 25;623(1-3):52-64. Epub 2009 Sep 24.PMID: 19782067 [PubMed - indexed for MEDLINE]Related citations

Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine.

Zhuang ZY, Kawasaki Y, Tan PH, Wen YR, Huang J, Ji RR.

Brain Behav Immun. 2007 Jul;21(5):642-51. Epub 2006 Dec 15.PMID: 17174525 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.

Zhuang ZY, Wen YR, Zhang DR, Borsello T, Bonny C, Strichartz GR, Decosterd I, Ji RR.

J Neurosci. 2006 Mar 29;26(13):3551-60.PMID: 16571763 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury.

Terayama R, Omura S, Fujisawa N, Yamaai T, Ichikawa H, Sugimoto T.

Neuroscience. 2008 Jun 2;153(4):1245-55. Epub 2008 Mar 26.PMID: 18440713 [PubMed - indexed for MEDLINE]Related citations