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    Results: 1 to 20 of 96

    1.

    Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence.

    Bredesen DE.

    Mol Neurodegener. 2009 Jun 26;4:27.

    PMID:
    19558683
    [PubMed - in process]
    Free PMC Article

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    2.

    Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain.

    Takeda K, Araki W, Akiyama H, Tabira T.

    FASEB J. 2004 Nov;18(14):1755-7. Epub 2004 Sep 13.

    PMID:
    15364896
    [PubMed - indexed for MEDLINE]
    Free Article

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    3.

    Caspases as therapeutic targets in Alzheimer's disease: is it time to "cut" to the chase?

    Rohn TT, Head E.

    Int J Clin Exp Pathol. 2009;2(2):108-18. Epub 2008 Jun 10.

    PMID:
    19079646
    [PubMed]
    Free PMC Article

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    4.

    beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.

    McPhie DL, Golde T, Eckman CB, Yager D, Brant JB, Neve RL.

    Brain Res Mol Brain Res. 2001 Dec 16;97(1):103-13.

    PMID:
    11744168
    [PubMed - indexed for MEDLINE]

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    5.

    The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.

    Storey E, Cappai R.

    Neuropathol Appl Neurobiol. 1999 Apr;25(2):81-97. Review.

    PMID:
    10215996
    [PubMed - indexed for MEDLINE]

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    6.

    Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies.

    Evin G, Sernee MF, Masters CL.

    CNS Drugs. 2006;20(5):351-72. Review.

    PMID:
    16696577
    [PubMed - indexed for MEDLINE]

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    7.

    Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.

    Parkin ET, Watt NT, Hussain I, Eckman EA, Eckman CB, Manson JC, Baybutt HN, Turner AJ, Hooper NM.

    Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11062-7. Epub 2007 Jun 15.

    PMID:
    17573534
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    8.

    Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ε-mediated metalloproteinase 2 and 9 levels in β-amyloid infused Alzheimer's disease rat model.

    Zara S, Rapino M, Sozio P, Di Stefano A, Nasuti C, Cataldi A.

    Brain Res. 2011 Sep 15;1412:79-87. Epub 2011 Jul 20.

    PMID:
    21820649
    [PubMed - in process]

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    9.

    Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.

    Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, Clarke EE, Zheng H, Van Der Ploeg LH, Ruffolo SC, Thornberry NA, Xanthoudakis S, Zamboni RJ, Roy S, Nicholson DW.

    Cell. 1999 Apr 30;97(3):395-406.

    PMID:
    10319819
    [PubMed - indexed for MEDLINE]

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    10.

    Caspase cleavage of the amyloid precursor protein is prevented after overexpression of bcl-2 in a triple transgenic mouse model of Alzheimer's disease.

    Kumasaka DK, Galvan V, Head E, Rohn TT.

    Int J Physiol Pathophysiol Pharmacol. 2009 Jan 12;1(1):48-56.

    PMID:
    20411026
    [PubMed]
    Free PMC Article

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    11.

    [Alzheimer's dementia and amyloid precursor-protein].

    Blom N, Linnemann D.

    Ugeskr Laeger. 1992 Apr 6;154(15):1010-5. Review. Danish.

    PMID:
    1566508
    [PubMed - indexed for MEDLINE]

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    12.

    Effects of gamma-secretase cleavage-region mutations on APP processing and Abeta formation: interpretation with sequential cleavage and alpha-helical model.

    Tan J, Mao G, Cui MZ, Kang SC, Lamb B, Wong BS, Sy MS, Xu X.

    J Neurochem. 2008 Nov;107(3):722-33. Epub 2008 Sep 20.

    PMID:
    18752644
    [PubMed - indexed for MEDLINE]

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    13.

    The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.

    Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP.

    Nature. 2006 Mar 23;440(7083):528-34. Erratum in: Nature. 2007 Mar 15;446(7133):342.

    PMID:
    16554819
    [PubMed - indexed for MEDLINE]

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    14.

    Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome.

    Abrahamson EE, Ikonomovic MD, Ciallella JR, Hope CE, Paljug WR, Isanski BA, Flood DG, Clark RS, DeKosky ST.

    Exp Neurol. 2006 Feb;197(2):437-50. Epub 2005 Nov 21.

    PMID:
    16300758
    [PubMed - indexed for MEDLINE]

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    15.

    Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity.

    Lu DC, Soriano S, Bredesen DE, Koo EH.

    J Neurochem. 2003 Nov;87(3):733-41.

    PMID:
    14535955
    [PubMed - indexed for MEDLINE]

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    16.

    Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein.

    Harris JA, Devidze N, Halabisky B, Lo I, Thwin MT, Yu GQ, Bredesen DE, Masliah E, Mucke L.

    J Neurosci. 2010 Jan 6;30(1):372-81.

    PMID:
    20053918
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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    17.

    Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.

    Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.

    J Neurochem. 2005 Sep;94(5):1189-201. Epub 2005 Jun 30.

    PMID:
    15992373
    [PubMed - indexed for MEDLINE]

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    18.

    Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis.

    Wei W, Norton DD, Wang X, Kusiak JW.

    Brain. 2002 Sep;125(Pt 9):2036-43.

    PMID:
    12183349
    [PubMed - indexed for MEDLINE]
    Free Article

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    19.

    Redox-active metals, oxidative stress, and Alzheimer's disease pathology.

    Huang X, Moir RD, Tanzi RE, Bush AI, Rogers JT.

    Ann N Y Acad Sci. 2004 Mar;1012:153-63. Review.

    PMID:
    15105262
    [PubMed - indexed for MEDLINE]

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    20.

    Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition.

    Harris-White ME, Frautschy SA.

    Curr Drug Targets CNS Neurol Disord. 2005 Oct;4(5):469-80. Review.

    PMID:
    16266282
    [PubMed - indexed for MEDLINE]

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