Warning: The NCBI web site requires JavaScript to function. more...
Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1.
Gao D, Inuzuka H, Tseng A, Wei W.
Cell Div. 2009 Jun 23;4:11.
Related citations
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.
Gao D, Inuzuka H, Tseng A, Chin RY, Toker A, Wei W.
Nat Cell Biol. 2009 Apr;11(4):397-408. Epub 2009 Mar 8.
Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase.
Rodier G, Coulombe P, Tanguay PL, Boutonnet C, Meloche S.
EMBO J. 2008 Feb 20;27(4):679-91. Epub 2008 Jan 31.
Dissection of the APCCdh1-Skp2 cascade in breast cancer.
Fujita T, Liu W, Doihara H, Date H, Wan Y.
Clin Cancer Res. 2008 Apr 1;14(7):1966-75.
Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2.
Boutonnet C, Tanguay PL, Julien C, Rodier G, Coulombe P, Meloche S.
Cell Cycle. 2010 Mar 1;9(5):975-9. Epub 2010 Mar 9.
Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization.
Bashir T, Pagan JK, Busino L, Pagano M.
Cell Cycle. 2010 Mar 1;9(5):971-4. Epub 2010 Mar 9.
Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis.
Fujita T, Liu W, Doihara H, Wan Y.
Am J Pathol. 2008 Jul;173(1):217-28. Epub 2008 Jun 5.
Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.
Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M.
Nature. 2004 Mar 11;428(6979):190-3.
Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation.
Cuende J, Moreno S, Bolaños JP, Almeida A.
Oncogene. 2008 May 22;27(23):3339-44. Epub 2008 Jan 21.
The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells.
Shapira M, Kakiashvili E, Rosenberg T, Hershko DD.
Breast Cancer Res. 2006;8(4):R46.
Atypical protein kinase Cι (PKCι) promotes metastasis of esophageal squamous cell carcinoma by enhancing resistance to Anoikis via PKCι-SKP2-AKT pathway.
Liu SG, Wang BS, Jiang YY, Zhang TT, Shi ZZ, Yang Y, Yang YL, Wang XC, Lin DC, Zhang Y, Yang H, Cai Y, Zhan QM, Wang MR.
Mol Cancer Res. 2011 Apr;9(4):390-402. Epub 2011 Feb 10.
SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis.
Calvisi DF, Ladu S, Pinna F, Frau M, Tomasi ML, Sini M, Simile MM, Bonelli P, Muroni MR, Seddaiu MA, Lim DS, Feo F, Pascale RM.
Gastroenterology. 2009 Nov;137(5):1816-26.e1-10. Epub 2009 Aug 15.
Cdh1-anaphase-promoting complex targets Skp2 for destruction in transforming growth factor beta-induced growth inhibition.
Liu W, Wu G, Li W, Lobur D, Wan Y.
Mol Cell Biol. 2007 Apr;27(8):2967-79. Epub 2007 Feb 5.
Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway.
Foster JS, Fernando RI, Ishida N, Nakayama KI, Wimalasena J.
J Biol Chem. 2003 Oct 17;278(42):41355-66. Epub 2003 Aug 6.
Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells.
Chen JY, Wang MC, Hung WC.
J Cell Physiol. 2011 Feb;226(2):407-13.
An in vivo study of Cdh1/APC in breast cancer formation.
Int J Cancer. 2009 Aug 15;125(4):826-36.
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.
Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG Jr.
Nature. 2004 Mar 11;428(6979):194-8.
Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.
McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand FE, Navolanic PM, Terrian DM, Franklin RA, D'Assoro AB, Salisbury JL, Mazzarino MC, Stivala F, Libra M.
Adv Enzyme Regul. 2006;46:249-79. Epub 2006 Jul 18.
PI3K/Akt signaling regulates p27(kip1) expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27(kip1) regulation in LNCaP and PC346 cells.
van Duijn PW, Trapman J.
Prostate. 2006 May 15;66(7):749-60.
The dual effects of Cdh1/APC in myogenesis.
Li W, Wu G, Wan Y.
FASEB J. 2007 Nov;21(13):3606-17. Epub 2007 Jun 29.
Filter your results:
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on