PubMed

Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes.

Baker TB, Weiss RB, Bolt D, von Niederhausern A, Fiore MC, Dunn DM, Piper ME, Matsunami N, Smith SS, Coon H, McMahon WM, Scholand MB, Singh N, Hoidal JR, Kim SY, Leppert MF, Cannon DS.

Nicotine Tob Res. 2009 Jul;11(7):785-96. Epub 2009 May 12.PMID: 19436041 [PubMed - indexed for MEDLINE]Related articles

A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.

Weiss RB, Baker TB, Cannon DS, von Niederhausern A, Dunn DM, Matsunami N, Singh NA, Baird L, Coon H, McMahon WM, Piper ME, Fiore MC, Scholand MB, Connett JE, Kanner RE, Gahring LC, Rogers SW, Hoidal JR, Leppert MF.

PLoS Genet. 2008 Jul 11;4(7):e1000125.PMID: 18618000 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking.

Sherva R, Wilhelmsen K, Pomerleau CS, Chasse SA, Rice JP, Snedecor SM, Bierut LJ, Neuman RJ, Pomerleau OF.

Addiction. 2008 Sep;103(9):1544-52.PMID: 18783506 [PubMed - indexed for MEDLINE]Related articlesFree article

The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer.

Spitz MR, Amos CI, Dong Q, Lin J, Wu X.

J Natl Cancer Inst. 2008 Nov 5;100(21):1552-6. Epub 2008 Oct 28.PMID: 18957677 [PubMed - indexed for MEDLINE]Related articlesFree article

Nicotinic receptor gene variants influence susceptibility to heavy smoking.

Stevens VL, Bierut LJ, Talbot JT, Wang JC, Sun J, Hinrichs AL, Thun MJ, Goate A, Calle EE.

Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3517-25. Epub 2008 Nov 24.PMID: 19029397 [PubMed - indexed for MEDLINE]Related articles

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

Saccone NL, Wang JC, Breslau N, Johnson EO, Hatsukami D, Saccone SF, Grucza RA, Sun L, Duan W, Budde J, Culverhouse RC, Fox L, Hinrichs AL, Steinbach JH, Wu M, Rice JP, Goate AM, Bierut LJ.

Cancer Res. 2009 Sep 1;69(17):6848-56. Epub 2009 Aug 25.PMID: 19706762 [PubMed - indexed for MEDLINE]Related articles

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.

Saccone NL, Saccone SF, Hinrichs AL, Stitzel JA, Duan W, Pergadia ML, Agrawal A, Breslau N, Grucza RA, Hatsukami D, Johnson EO, Madden PA, Swan GE, Wang JC, Goate AM, Rice JP, Bierut LJ.

Am J Med Genet B Neuropsychiatr Genet. 2009 Jun 5;150B(4):453-66.PMID: 19259974 [PubMed - indexed for MEDLINE]Related articles

Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence.

Silverman MA, Neale MC, Sullivan PF, Harris-Kerr C, Wormley B, Sadek H, Ma Y, Kendler KS, Straub RE.

Am J Med Genet. 2000 Oct 9;96(5):646-53.PMID: 11054772 [PubMed - indexed for MEDLINE]Related articles

Assessing dimensions of nicotine dependence: an evaluation of the Nicotine Dependence Syndrome Scale (NDSS) and the Wisconsin Inventory of Smoking Dependence Motives (WISDM).

Piper ME, McCarthy DE, Bolt DM, Smith SS, Lerman C, Benowitz N, Fiore MC, Baker TB.

Nicotine Tob Res. 2008 Jun;10(6):1009-20. Erratum in: Nicotine Tob Res. 2008 Sep;10(9):1517. PMID: 18584464 [PubMed - indexed for MEDLINE]Related articlesFree article

Intermediacy and gene-environment interaction: the example of CHRNA5-A3 region, smoking, nicotine dependence, and lung cancer.

Wacholder S, Chatterjee N, Caporaso N.

J Natl Cancer Inst. 2008 Nov 5;100(21):1488-91. Epub 2008 Oct 28. No abstract available. PMID: 18957674 [PubMed - indexed for MEDLINE]Related articlesFree article

A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence.

Grucza RA, Wang JC, Stitzel JA, Hinrichs AL, Saccone SF, Saccone NL, Bucholz KK, Cloninger CR, Neuman RJ, Budde JP, Fox L, Bertelsen S, Kramer J, Hesselbrock V, Tischfield J, Nurnberger JI Jr, Almasy L, Porjesz B, Kuperman S, Schuckit MA, Edenberg HJ, Rice JP, Goate AM, Bierut LJ.

Biol Psychiatry. 2008 Dec 1;64(11):922-9. Epub 2008 Jun 2.PMID: 18519132 [PubMed - indexed for MEDLINE]Related articlesFree article

The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco.

Zeiger JS, Haberstick BC, Schlaepfer I, Collins AC, Corley RP, Crowley TJ, Hewitt JK, Hopfer CJ, Lessem J, McQueen MB, Rhee SH, Ehringer MA.

Hum Mol Genet. 2008 Mar 1;17(5):724-34. Epub 2007 Nov 30.PMID: 18055561 [PubMed - indexed for MEDLINE]Related articlesFree article

The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults.

Schlaepfer IR, Hoft NR, Collins AC, Corley RP, Hewitt JK, Hopfer CJ, Lessem JM, McQueen MB, Rhee SH, Ehringer MA.

Biol Psychiatry. 2008 Jun 1;63(11):1039-46. Epub 2007 Dec 27.PMID: 18163978 [PubMed - indexed for MEDLINE]Related articlesFree article

Variants in nicotinic receptors and risk for nicotine dependence.

Bierut LJ, Stitzel JA, Wang JC, Hinrichs AL, Grucza RA, Xuei X, Saccone NL, Saccone SF, Bertelsen S, Fox L, Horton WJ, Breslau N, Budde J, Cloninger CR, Dick DM, Foroud T, Hatsukami D, Hesselbrock V, Johnson EO, Kramer J, Kuperman S, Madden PA, Mayo K, Nurnberger J Jr, Pomerleau O, Porjesz B, Reyes O, Schuckit M, Swan G, Tischfield JA, Edenberg HJ, Rice JP, Goate AM.

Am J Psychiatry. 2008 Sep;165(9):1163-71. Epub 2008 Jun 2.PMID: 18519524 [PubMed - indexed for MEDLINE]Related articlesFree article

CHRNA4 and tobacco dependence: from gene regulation to treatment outcome.

Hutchison KE, Allen DL, Filbey FM, Jepson C, Lerman C, Benowitz NL, Stitzel J, Bryan A, McGeary J, Haughey HM.

Arch Gen Psychiatry. 2007 Sep;64(9):1078-86.PMID: 17768273 [PubMed - indexed for MEDLINE]Related articlesFree article

Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence.

Li MD, Beuten J, Ma JZ, Payne TJ, Lou XY, Garcia V, Duenes AS, Crews KM, Elston RC.

Hum Mol Genet. 2005 May 1;14(9):1211-9. Epub 2005 Mar 24.PMID: 15790597 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of nicotine lozenges on affective smoking withdrawal symptoms: secondary analysis of a randomized, double-blind, placebo-controlled clinical trial.

Shiffman S.

Clin Ther. 2008 Aug;30(8):1461-75.PMID: 18803988 [PubMed - indexed for MEDLINE]Related articles

A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men.

Feng Y, Niu T, Xing H, Xu X, Chen C, Peng S, Wang L, Laird N, Xu X.

Am J Hum Genet. 2004 Jul;75(1):112-21. Epub 2004 May 20.PMID: 15154117 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.

Saccone SF, Hinrichs AL, Saccone NL, Chase GA, Konvicka K, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau O, Swan GE, Goate AM, Rutter J, Bertelsen S, Fox L, Fugman D, Martin NG, Montgomery GW, Wang JC, Ballinger DG, Rice JP, Bierut LJ.

Hum Mol Genet. 2007 Jan 1;16(1):36-49. Epub 2006 Nov 29.PMID: 17135278 [PubMed - indexed for MEDLINE]Related articlesFree article

A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.

Freathy RM, Ring SM, Shields B, Galobardes B, Knight B, Weedon MN, Smith GD, Frayling TM, Hattersley AT.

Hum Mol Genet. 2009 Aug 1;18(15):2922-7. Epub 2009 May 9.PMID: 19429911 [PubMed - indexed for MEDLINE]Related articlesFree article